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210 Possible Causes for Dark Urine, Enlargement of the Spleen, Pruritus

  • Primary Biliary Cirrhosis

    Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[disability-benefits-help.org] We report the case of a 52-year old woman who initially presented to the gastroenterology department for extreme fatigue, pale stools, dark urine and pruritus.[ncbi.nlm.nih.gov] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[ncbi.nlm.nih.gov]

  • Secondary Biliary Cirrhosis

    It is marked by jaundice, abdominal pain, steatorrhea, and enlargement of the liver and spleen. congestive cirrhosis cirrhosis resulting from increased hepatic venous pressure[medical-dictionary.thefreedictionary.com] With an increase in the appearance of jaundice is observed dark urine and feces discolored.[medicalformat.com] SECONDARY BILIARY CI RR H OS I S Symptoms Clinical features · Jaundice · Pruritus · Biliary colics.[medicscientist.com]

  • Primary Sclerosing Cholangitis

    These include: an enlarged liver or spleen, anaemia , cirrhosis , female sex and older age. Increasing bilirubin also correlates with disease progression.[myvmc.com] Additional symptoms include a general feeling of ill health (malaise); abdominal pain, especially the upper right portion of the abdomen; nausea; dark urine; light-colored[rarediseases.org] Abstract Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[ncbi.nlm.nih.gov]

  • Cholestasis

    Dark urine Possible causes: pregnancy androgens birth control pills antibiotics (such as TMP/SMX) abdominal mass (e.g. cancer) biliary atresia and other pediatric liver diseases[en.wikipedia.org] […] of the liver and spleen that is not normal Fatigue (tired all of the time) Poor feeding, upset belly, and throwing up Problems that may arise include: Problems absorbing[cincinnatichildrens.org] All three patients showed significant improvement in pruritus, with none or minimal pruritus in one patient with primary biliary cirrhosis.[ncbi.nlm.nih.gov]

  • Intrahepatic Cholestasis

    […] of the liver and spleen that is not normal Fatigue (tired all of the time) Poor feeding, upset belly, and throwing up Problems that may arise include: Problems absorbing[cincinnatichildrens.org] Associated manifestations include fatigue, loss of appetite, dark urine and pale stools. Hepatomegaly is also a common finding.[orpha.net] Pruritus was diminished from a mean of 4 (range 4-4) preoperatively to a mean of 2 (4-0).[ncbi.nlm.nih.gov]

  • Progressive Familial Intrahepatic Cholestasis

    […] liver and spleen (hepatosplenomegaly).[ghr.nlm.nih.gov] Clinical description Clinical signs of cholestasis (discolored stools, dark urine) appear within the first year of life in about one third of patients, or later with recurrent[orpha.net] Abstract Biliary diversion offers a potential option for intractable pruritus in children with chronic cholestatic disorders.[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    urine.[txliver.com] A pediatric specialist may find an enlarged liver or spleen during an examination of your child’s body. Blood tests.[rileychildrens.org] Fatigue Abdominal pain Joint pain Itching (pruritus) Jaundice An enlarged liver Abnormal blood vessels on the skin (spider angiomas) Nausea and vomiting Loss of appetite Skin[columbiasurgery.org]

  • Portal Cirrhosis

    Other complications Portal hypertension may cause the spleen to become enlarged.[upmc.com] The same bile pigment, bilirubin, which is responsible for the yellow skin tones of jaundice can turn urine dark.[chp.edu] Symptoms: abdominal distension, weight loss, fatigue, jaundice, pruritus, coffee-ground vomit, melaena and confusion.[kenhub.com]

  • Drug-induced Cholestatic Hepatitis

    The typical presentation of symptoms includes nausea, fatigue and pruritus followed by dark urine and jaundice .[livertox.nih.gov] In advanced cases, patients will develop enlarged livers and spleens, jaundice, and ascites (abnormal buildup of fluid in the abdomen).[medicinenet.com] References Bunchorntavakul C, Reddy KR: Pruritus in chronic cholestatic liver disease. Clin Liver Dis 2012;16: 331–346.[karger.com]

  • Indian Childhood Cirrhosis

    The same bile pigment, bilirubin, which is responsible for the yellow skin tones of jaundice can turn urine dark.[chp.edu] "The child had severe difficulty in breathing and had jaundice with enlargement of liver and spleen besides signs of liver and respiratory failure.[dailymail.co.uk] The initial presenting complaint was abdominal distention and pruritus. All three had a rapid and fatal course.[ingentaconnect.com]

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