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14 Possible Causes for Dark Urine, Hyperbilirubinemia, Onset in First Weeks or Months of Life

  • Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] It can also be accompanied by: jaundice pale stools dark urine abdominal pain nausea See your doctor if you have itching in pregnancy.[healthline.com] We believe our patient’s persistent direct hyperbilirubinemia with biopsy-confirmed cholestasis was also likely related to his AHC.[pediatrics.aappublications.org]

  • Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution[ncbi.nlm.nih.gov] urine and pale stools.[goodtoknow.co.uk]

  • Glycogen Storage Disease Type 2

    Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[genedx.com] Deletion Syndrome, Adrenoleukodystrophy, Critical Congenital Heart Disease, Fabry Disease, Hemoglobin H, Krabbe Disease, MPS 1 (alpha-L-idurinidase deficiency), Neonatal Hyperbilirubinemia[us5.campaign-archive1.com] […] fixed myopathy in some patients Systemic features Gout: Hyperuricemia Gastric ulcer Laboratory Serum CK During episodes: High Between episodes: Often normal Hyperuricemia Hyperbilirubinemia[neuromuscular.wustl.edu]

  • Benign Recurrent Intrahepatic Cholestasis Type 1

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] Pale stools and dark urine - pale stools occur as no bilirubin reaches the gastrointestinal tract and dark urine results from reflux of conjugated bilirubin into blood which[patient.info] HYPERBILIRUBINEMIA 2.[slideshare.net]

  • Hepatoerythropoietic Porphyria

    […] of seizures in the first weeks or months of life.[mendelian.co] urine) Familial Mediterranean fever Best Tests Subscription Required Therapy Subscription Required References Subscription Required Last Reviewed: 03/09/2017 Last Updated[visualdx.com] , red urine, dark diapers that show a red fluorescence under UV light Phototherapy for hyperbilirubinemia leads to severe skin blistering.[merckmanuals.com]

  • Wolman Disease

    This particular form of these disorders is early in onset, usually developing within the first weeks or month of life.[disability-benefits-help.org] They may have signs of bile duct problems, like itchiness, jaundice, pale stool, or dark urine. Their feces may be excessively greasy.[en.wikipedia.org] Significant hyperbilirubinemia (peak total and direct bilirubin levels: 54.4 and 45.8 mg/dl, respectively) developed at 7 weeks from BMT.[nature.com]

  • Sepsis

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] The rash may be a reddish discoloration or small dark red dots seen throughout the body.[emedicinehealth.com] Hyperbilirubinemia did not return in 3 months.[ncbi.nlm.nih.gov]

  • Benign Recurrent Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] HYPERBILIRUBINEMIA 2.[slideshare.net] Associated symptoms include anorexia, weight loss, vomiting, fatigue, dark urine and pale stools. Physical examination is usually unremarkable.[ispub.com]

  • Streptococcal Septicemia

    […] are infected within the first week of life, it is called early-onset GBS disease.[sepsis.org] Clinical findings may include dark-colored urine, swelling of different parts of the body (edema), and high blood pressure.[en.wikipedia.org] […] homocystinaemia (Br Eng) hydremia (Am Eng) or hydraemia (Br Eng) hydroxyprolinemia (Am Eng) or hydroxyporlinaemia (Br Eng) hyperamylasemia (Am Eng) or hyperamylasaemia (Br Eng) hyperbilirubinemia[wordlister.blogspot.com]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[findzebra.com] […] pigmentation: caregivers should make direct observations  Pale or alcholic stools are a hallmark of cholestasis because bilirubin gives stool its color  Dark urine is indicative[slideplayer.com] The condition accounts for 1% to 2% of all occurrences of conjugated hyperbilirubinemia during infancy.[symptoma.com]

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