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1,896 Possible Causes for Dark Urine, Mutation in the Tight Junction Protein 2 Gene

  • Intrahepatic Cholestasis

    Associated manifestations include fatigue, loss of appetite, dark urine and pale stools. Hepatomegaly is also a common finding.[orpha.net] Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs).[ncbi.nlm.nih.gov] Less common symptoms include dark urine, pale stools, pain under your ribs or shoulder blade, and some women get jaundiced.[community.babycenter.com]

  • Progressive Familial Intrahepatic Cholestasis

    Clinical description Clinical signs of cholestasis (discolored stools, dark urine) appear within the first year of life in about one third of patients, or later with recurrent[orpha.net] It results from mutations in the TJP2 gene, which is responsible for the production of the tight junction protein 2, also known as zona occludens 2 (ZO-2).[symptoma.com] Clinical signs of cholestasis (discolored stools, dark urine) usually appear in the first months of life with recurrent or permanent jaundice associated with hepatomegaly[orpha.net]

  • Vitamin B12 Deficiency

    Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Cholelithiasis

    The presence of associated bile duct stones (choledocholithiasis) should be suspected through clinical signs such as jaundice and dark urine (bilirubinuria), together with[link.springer.com] urine Why is medication give PO to pt with chronic pancreatitis given enteric coated medications?[quizlet.com] RUQ /epigastric pain More severe and prolonged ( 6 hours ) than in cholelithiasis Postprandial Nausea, vomiting Signs of extrahepatic cholestasis : jaundice, pale stool, dark[amboss.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Cholestatic Jaundice

    Symptoms of obstructive jaundice include the typical yellowing of jaundice as well as dark urine, pale feces, and itching . Also known as post-hepatic jaundice.[medicinenet.com] Symptoms & Effects of obstructive jaundice may include: Dark Urine Pale Faeces Itching Compare obstructive jaundice with hepatocellular jaundice and haemolytic jaundice.[ivyroses.com] Patients with medical jaundice will have yellowing of the skin, without dark urine or light-coloured stools.[healthxchange.sg]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Choledocholithiasis

    Patients may also experience clay-colored stools and dark urine.[jamanetwork.com] Dark urine. Symptoms associated with Pancreatitis. Charcot's Triad: [ edit ] Clasically seen in common-bile-duct-stone.[en.wikibooks.org] urine and acholic stool can be seen in complete or near-complete biliary obstruction.[clinicaladvisor.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Cholestasis

    It can also be accompanied by: jaundice pale stools dark urine abdominal pain nausea See your doctor if you have itching in pregnancy.[healthline.com] Jaundice, dark urine, light-colored stools, and generalized itchiness are characteristic symptoms of cholestasis.[msdmanuals.com] Both types of cholestasis result in the same symptoms: jaundice, which is a yellowing of your skin and the white of your eyes dark urine light-colored stool pain in your abdomen[healthline.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Portal Cirrhosis

    Dark urine. What are the 4 Stages and Symptoms of Cirrhosis. Alteration in personality.[marylandhearingcenter.com] Jaundice (yellowing of the eyes and skin) associated with dark, teacolored urine i.[singhealth.com.sg] urine, enlarged veins around belly button, flapping hand tremor, itching, mental confusion, Poor concentration and memory, muscle weakness, red palms, swelling, swelling[slideshare.net]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Glomerulonephritis

    When To Call A Professional Call your doctor if you or your child is putting out less urine then normal or if urine looks bloody or abnormally dark.[drugs.com] This is in contrast to another type of glomerulonephritis, post-streptococcal glomerulonephritis, where the blood-stained or dark urine episode does not occur until about[mydr.com.au] (dark, rust-colored, or brown urine) Foamy urine (due to excess protein in the urine) Swelling (edema) of the face, eyes, ankles, feet, legs, or abdomen Symptoms may also[nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Viral Hepatitis

    In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com] Symptoms of acute (newly acquired) hepatitis include: fever, fatigue, loss of appetite, nausea, vomiting, abdominal/stomach pain, dark urine, clay-colored feces, joint pain[dph.georgia.gov] HCV or HBV carriers may exhibit the following symptoms: Fever Fatigue Decreased appetite Nausea Vomiting Abdominal pain Dark urine Grey-coloured faeces Joint pain Jaundice[roche.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene

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