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42 Possible Causes for Dark Urine, Polychromasia in Peripheral Blood Smear

  • Paroxysmal Cold Hemoglobinuria

    He was admitted because of dark urine after exposure to cold air.[ncbi.nlm.nih.gov] Tests include complete blood count (CBC) and peripheral smear.[emedicine.com] Systemic symptoms include the passage of dark urine, severe pain in the back and legs, headache, vomiting, diarrhea, and moderate reticulocytosis.[medical-dictionary.thefreedictionary.com]

  • Cold Agglutinin Disease

    Symptoms during hemolytic crises'' may include severe pain in the back and legs, headache, vomiting, diarrhea, dark urine and hepatosplenomegaly.[orpha.net] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] Other laboratory findings include reticulocytosis, positive DAT, auto agglutination and/or rouleaux on peripheral blood smear, polychromasia, and mild to moderate anisocytosis[keralamedicaljournal.com]

  • Autoimmune Hemolytic Anemia

    A 41-year-old woman with Crohn's disease presented to our emergency room (ER) with dark urine, dizziness, and shortness of breath.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] The disease is characterized by symptoms due to the anemia including fatigue, exertional dyspnea, and, more rarely, jaundice and dark urine in case of severe hemolysis.[orpha.net]

  • Nonimmune Hemolysis

    The macrophages then proceed in destroying the “tagged” RBCs producing the typical hemolytic by-products which cause some of the clinically relevant signs such as dark urine[pedclerk.bsd.uchicago.edu] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] Symptoms may include any of the following: Dark urine Fatigue Pale skin color Rapid heart rate Shortness of breath Yellow skin and whites of the eyes ( jaundice ) Stopping[medlineplus.gov]

  • Hemolytic Uremic Syndrome

    You have bloody or dark urine or bowel movements. You have questions or concerns about your condition or care. When should I seek immediate care or call 911?[drugs.com] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[ziaristionline.ro] urine.[slideshare.net]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    This type of anemia leads to paleness, yellowing of the skin and whites of the eyes ( jaundice ), dark urine, fatigue , shortness of breath, and a rapid heart rate.[medicinenet.com] The peripheral blood smear showed polychromasia, anisopoikilocytosis and reticulocytosis (the reticulocyte count was 14.6%). Urine was positive for hemoglobinuria.[ncbi.nlm.nih.gov] Symptoms during a hemolytic episode may include dark urine, fatigue, paleness, rapid heart rate, shortness of breath, and yellowing of the skin ( jaundice ).[rarediseases.info.nih.gov]

  • Atypical Hemolytic Uremic Syndrome

    The patient also reported noticing dark urine for several days although denied any frank blood and also denied any diarrhea.[pubs.sciepub.com] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[ziaristionline.ro]

  • Acquired Hemolytic Anemia

    urine A feeling of abdominal fullness related to an enlarged spleen How Is AIHA Diagnosed?[webmd.com] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] The disease is characterized by symptoms due to the anemia including fatigue, exertional dyspnea, and, more rarely, jaundice and dark urine in case of severe hemolysis.[orpha.net]

  • Anemia due to Glutathione Metabolism Disorder

    Hemolytic anemia is characterized by chills, dark urine, fatigue and a rapid heart rate.[livestrong.com] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[clinicaladvisor.com] urine Hemoglobinuria Hemolysis resulting in hemoglobin filtering into the urine Low or absent haptoglobin Haptoglobin binds hemoglobin after hemolysis and the complex is[pathophys.org]

  • Congenital Dyserythropoietic Anemia Type 1

    She did not report any episodes of acute jaundice in the past, or any dark urine (Table 1 ).[cureus.com] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[unboundmedicine.com] The disorder can cause: recurring infections dark-colored urine, particularly in the morning fatigue shortness of breath abnormally pale skin back pain abdominal pain headaches[healthline.com]

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