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15 Possible Causes for Decreased Number of Myelinated Fibers (Sural Nerve Biopsy)

Did you mean: Decreased Number of Myelinated Fibers (Sural Nerve Biopsy

  • Neuropathy

    Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[ncbi.nlm.nih.gov] Although the tendon reflexes are decreased or absent, there is no muscle atrophy or muscle weakness.[ncbi.nlm.nih.gov]

  • Déjerine-Sottas Disease

    A sural nerve biopsy specimen showed marked decreases in the numbers of both large and small myelinated fibers, abundant onion-bulb formation, and hypomyelination.[ncbi.nlm.nih.gov] Motor and sensory nerve conduction studies showed absent motor and sensory responses on electrical stimulation of the limb nerves.[ncbi.nlm.nih.gov]

  • Acute Intermittent Porphyria

    Open nerve and muscle biopsies showed significantly decreased numbers of myelinated fibers in the sural nerve and atrophy of type I and II fibers in the quadriceps muscle,[doi.org] Sensory nerve conduction velocities were absent in ulnar, sural, and plantar nerves, while peroneal motor conduction velocity was decreased (24 m/s; normal, 40 m/s), compatible[doi.org]

  • Esophageal Spasm

    Right sural nerve biopsy showed significantly decreased numbers of small myelinated fibers.[ncbi.nlm.nih.gov] She presented with chronic esophageal transit failure, constipation, and numbness of the hands and feet, Adie's pupil, thermal hypoalgesia, and decreased deep tendon reflexes[ncbi.nlm.nih.gov]

  • Hereditary Sensory Neuropathy

    Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[doi.org] Although the tendon reflexes are decreased or absent, there is no muscle atrophy or muscle weakness.[doi.org]

  • Xeroderma Pigmentosum

    (D) Representative image of sural nerve biopsy (embedded in Epon and stained with toluidine blue) from patient 1 demonstrating a decrease in the number of myelinated fibers[ng.neurology.org]

  • Familial Dysautonomia

    Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[dx.doi.org] Although the tendon reflexes are decreased or absent, there is no muscle atrophy or muscle weakness.[dx.doi.org]

  • TTR Amyloidosis with Polyneuropathy

    Morphometric data on the number and caliber of myelinated fibers in the sural nerve biopsy specimen from patients with early-stage FAP showed a greater reduction of small-caliber[jamanetwork.com] Degenerative changes in the axon, myelin sheath, and Schwann cells and the decrease in collagen fibers paralleled the severity of the peripheral nerve disturbances.[jamanetwork.com] In patients with more advanced FAP, the numbers of myelinated fibers were decreased. 15 Biochemical aspects of amyloidogenesis It is widely believed that stabilizing tetrameric[jamanetwork.com]

  • Congenital Neuropathy with Arthrogryposis Multiplex

    Sural nerve biopsy showed a severe decrease in the number of large myelinated fibers. 15 Case: 15 Hypotonia at age 4 months, gastrostomy at age 11 months, ventilation at age[medcraveonline.com] Sural nerve biopsy showed nearly complete absence of myelination of both large and small fibers. 15 Case: 14 At 3 years old, hypotonia and gross motor delay.[medcraveonline.com]

  • Xeroderma Pigmentosum Complementation Group F

    (D) Representative image of sural nerve biopsy (embedded in Epon and stained with toluidine blue) from patient 1 demonstrating a decrease in the number of myelinated fibers[ng.neurology.org]

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