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24 Possible Causes for Decreased Number of Myelinated Fibers (Sural Nerve Biopsy), Weakness

Did you mean: Decreased Number of Myelinated Fibers (Sural Nerve Biopsy, Weakness

  • Neuropathy

    Weakness and loss of sensation may be associated with lack of balance and falling.[mayoclinic.org] Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[ncbi.nlm.nih.gov] Acute Immune Infantile Weakness Childhood Onset Hereditary Motor-Sensory Motor Sensory Relapsing Cranial Upper extremity Cervical root Lower extremity Lumbosacral root Large[neuromuscular.wustl.edu]

  • Acute Intermittent Porphyria

    Thus, AIP should be considered in the differential diagnosis of children presenting with unexplained abdominal pain, seizures, weakness and neuropathy.[ncbi.nlm.nih.gov] Open nerve and muscle biopsies showed significantly decreased numbers of myelinated fibers in the sural nerve and atrophy of type I and II fibers in the quadriceps muscle,[doi.org] […] dietary changes, infections diseases and surgery that trigger the appearance of symptoms, which include neurological disorders, abdominal pain, constipation, and muscle weakness[ncbi.nlm.nih.gov]

  • Déjerine-Sottas Disease

    Clinical onset of her condition was with congenital weakness of her distal four extremities, accompanied by peripheral facial nerve weakness, deafness, and nystagmus.[ncbi.nlm.nih.gov] A sural nerve biopsy specimen showed marked decreases in the numbers of both large and small myelinated fibers, abundant onion-bulb formation, and hypomyelination.[ncbi.nlm.nih.gov] Dejerine-Sottas disease with sensorineural hearing loss, nystagmus, and peripheral facial nerve weakness: de novo dominant point mutation of the PMP22 gene.[jmg.bmj.com]

  • Hereditary Sensory Neuropathy

    Muscle weakness and wasting were always present, often severe, and mainly affected dorsiflexion of the toes and feet.[ncbi.nlm.nih.gov] Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[doi.org] None had trophic limb changes, evidence of weakness, or a tendency to self-mutilation and each had normal motor studies on neurophysiological testing.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    The disease leads to distal sensory loss, distal muscle wasting and weakness, and variable neural deafness.[researchers.mq.edu.au] Pathologically, HSAN II demonstrates a virtual absence of myelinated fibers and a decreased number of unmyelinated fibers in sural nerve biopsies ( table 1 ).[anesthesiology.pubs.asahq.org] Type II evolves more slowly; weakness usually develops later in life.[merckmanuals.com]

  • Autonomic Neuropathy

    In both families, patients had severe muscle atrophy and weakness in limbs, limb girdle, and face; sensory impairment in the distal limbs; dysphagia, episodic intestinal pseudoobstruction[ncbi.nlm.nih.gov] Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[ojrd.biomedcentral.com] […] body mass index (BMI), comorbidity of hypertension and dyslipidemia, duration of PAN symptoms, associated neurological signs of impaired light touch sensation, and muscle weakness[ncbi.nlm.nih.gov]

  • Dysautonomia

    We present the case of a 41-year-old woman with 2 years of progressive burning pain, numbness, tingling, and weakness in a stocking-glove distribution who was found to have[ncbi.nlm.nih.gov] .: Sural nerve biopsy from a CMT1A case.[tankonyvtar.hu] , brain fog/forgetfulness, mood swings, anxiety, migraines, seizures, weakness in legs, bladder dysfunction, frequent urination, impotence, mild anemia, noise/light sensitivity[zebranation.org]

  • Familial Dysautonomia

    Computational analyses of the exon 20 5'ss itself predicted that this nine-nucleotide splicing signal, even when it contains the T C mutation, is not sufficiently weak to[ncbi.nlm.nih.gov] Pathology Sural nerve biopsy reveals a marked reduction in nerve size and depletion of large and small myelinated fibers but only a slightly decreased number of unmyelinated[doi.org] Exon 20 usage is susceptible to a weak 5’ splice site, as the exon has a weak 3’ splice site that has an A at the –3 position, and contains several exonic silencer elements[eurasnet.webarchive.hutton.ac.uk]

  • Esophageal Spasm

    At simultaneous manometry and fluoroscopy, with bread/barium boluses, the diagnosis of esophageal spasm in a relatively weak esophagus was made.[ncbi.nlm.nih.gov] Right sural nerve biopsy showed significantly decreased numbers of small myelinated fibers.[ncbi.nlm.nih.gov] [17.4%] using conventional manometry criteria; n 85 [7.9%] using EPT criteria) were heterogeneous in diagnosis and symptoms, with the majority ultimately categorized as weak[ncbi.nlm.nih.gov]

  • TTR Amyloidosis with Polyneuropathy

    The patient had muscle weakness and sensory disturbances in her extremities caused by severe peripheral neuropathy.[ncbi.nlm.nih.gov] Morphometric data on the number and caliber of myelinated fibers in the sural nerve biopsy specimen from patients with early-stage FAP showed a greater reduction of small-caliber[jamanetwork.com] This study aims to explore the genetic features of a Han Chinese family with FAP, characterized by bloating, alternating diarrhea and constipation, and weakness in his feet[ncbi.nlm.nih.gov]

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