Decreased Platelet Count: Causes & Reasons

Possible Causes for Decreased Platelet Count

Thrombocytopenia NOS, Thrombocytopenia [Disease/Finding], reduced platelet count, Thrombocytopenia NOS (disorder), Thrombocytopenia (disorder), Platelet count decreased, [fpnotebook.com]

Thrombocytopenia is a fancy word for decreased platelet count in the peripheral blood. Normal platelet count ranges between 150,000 to 500,000/microliter. [youtube.com]

Her platelet count decreased to 41 × 10/L, but was stable at ∼30 × 10/L for 3 months with platelet transfusion independency for 12 months. [ncbi.nlm.nih.gov]

Heparin-Induced Thrombocytopenia

This complex formation will result in platelet activation which causes formation of blood cloths leading to decrease platelet counts and eventually thrombocytopenia. [medical-institution.com]

We flushed this sensor with buffered saline preoperatively and noted no significant decrease in platelet count postoperatively. [ncbi.nlm.nih.gov]

Two distinct types of heparin induced thrombocytopenia can occur: HiT type I has no clinical relevance and is characterised by a transient decrease in platelet counts. [ibl-international.com]

Autoimmune Thrombocytopenia

However, the patient's platelet count decreased to 9 x 10(9) cells/L on day 222. The platelet-associated immunoglobulin G (PAIgG) values were elevated. [ncbi.nlm.nih.gov]

Although platelet counts gradually decreased within a few days post-transfusion, bleeding was stopped in all cases. [ncbi.nlm.nih.gov]

Viruses Chickenpox, mumps, rubella, Epstein-Barr virus, or parvovirus can decrease your platelet count for a while. People who have AIDS often develop thrombocytopenia. [nhlbi.nih.gov]

Thrombocytopenia Due to Sequestration

A decreased platelet count can result from a variety of mechanisms: Impaired Platelet Production: This is the major mechanism underlying neonatal thrombocytopenia. [learn.pediatrics.ubc.ca]

Rapid decrease in platelet count, increased red blood cell lysis are determined during laboratory examination. [iliveok.com]

Thrombocytopenia, or low platelets, is defined as a platelet count less than 150,000 platelets per microliter of blood. [livestrong.com]

Chronic Immune Thrombocytopenic Purpura

Ten patients subsequently decreased their platelet count, although they were able to attain CR after receiving six doses of anti-D (IgG)-coated RBCs. [ncbi.nlm.nih.gov]

[…] in platelet counts may cause emotional distress. [novartisoncology.com]

This results in a low blood platelet count (thrombocytopenia) that may produce bruising or excessive bleeding. [scripps.edu]

Immune Thrombocytopenic Purpura

Here we report a pediatric patient with ALL whose platelet counts decreased at the 102nd week of maintenance treatment. [ncbi.nlm.nih.gov]

In patient n. 4 a decrease of platelet counts was noted when CyA had been tentatively discontinued. [haematologica.org]

The platelet count decreased to 4000 cells/μL. The HCV viral load was undetectable at the end of PEG-IFN treatment and during follow-up for 5 months. [ncbi.nlm.nih.gov]

Cerebral Thrombotic Thrombocytopenic Purpura

The persistent decrease in platelet count initially posed limitations as the patient needed to undergo an invasive diagnostic procedure. [actamedicaphilippina.com.ph]

When accompanied by a decrease in the circulating platelets, it is called thrombocytopenic purpura ; when there is no decrease in the platelet count, it is called nonthrombocytopenic [medical-dictionary.thefreedictionary.com]

Decreased platelet count would support thrombotic thrombocytopenic purpura; leukocytosis might be seen in sepsis. [emedicine.medscape.com]

Drug-Induced Bone Marrow Suppression

If the platelet count decreases to 4 mm 3, the patient is diagnosed with thrombocytopenia ( 2 ). [spandidos-publications.com]

DIAGNOSIS AND CLINICAL PRESENTATION Agranulocytosis is characterized by a neutrophil granulocyte count < 0.5 × 109/l with no relevant decrease in haemoglobin and platelet [flipper.diff.org]

[…] of platelet count. 4 8 There have been reports of haematological side-effects from an Indian study by Karande and Kshirsagar, who reported them in 3.8% of cases 9 ; however [pmj.bmj.com]

Thrombotic Thrombocytopenic Purpura

In one case, after an initial response to plasma exchange, a decrease in platelet count was observed on Day 7. [ncbi.nlm.nih.gov]

Despite daily TPE, the patient had significant and unexpected decreases in platelet (PLT) counts and A-IPCs during her hospital course. [ncbi.nlm.nih.gov]

The large vWF proteins promote platelet activation and aggregation, leading to the formation of platelet thrombi. 7 Besides platelet consumption and harshly decreased platelet [academic.oup.com]

Thrombocytopenia-Absent Radius Syndrome

Usually this condition leads to mild decrease in platelet count, which is first detected in pregnancy and resolves after the delivery. [pediatriconcall.com]

The frequency of thrombocytopenia episodes decreases with age. By school age, near – normal platelet counts are expected. [ispub.com]

Thrombocytopenia absent radius (TAR) syndrome is characterized by bilateral absence of the radii with the presence of both thumbs and thrombocytopenia ( Thrombocytopenia Absent [imoselfi.gq]

Kasabach-Merritt Syndrome

platelet counts and sometimes other bleeding problems,[1] which can be life-threatening.[2] It is also known as hemangioma thrombocytopenia syndrome. [bionity.com]

It is a rare disease of infancy in which the thrombocytopenia (decreased platelet count) results from the hemangioma trapping and activating platelets, which in turn promotes [nicklauschildrens.org]

A rare disease, usually of infants, in which a vascular tumor leads to decreased platelet counts and sometimes other bleeding problems. Can be life-threatening. [standardofcare.com]

Atypical Hemolytic Uremic Syndrome

platelet count, and hemolytic anemia with schizocytes. [ncbi.nlm.nih.gov]

Early signs of systemic complement-mediated TMA include thrombocytopenia (platelet count below 150,000 or a decrease from baseline of at least 25%) and evidence of microangiopathic [en.wikipedia.org]

[…] period TMA event-free status [ Time Frame: 26 weeks ] No decrease in platelet count of > 25% from baseline, no plasma exchange or plasma infusion, and no initiation of new [clinicaltrials.gov]

Amegakaryocytic Thrombocytopenia

The typical clinical presentation of AATP is a marked decrease in platelet count in the peripheral blood ( 14 ). [spandidos-publications.com]

platelet counts for some weeks (G. [bloodjournal.org]

AATP is a clinically rare bleeding disease, characterized by a decrease or complete absence of megakaryocytes in the bone marrow and resulting in decreased platelet counts [spandidos-publications.com]

Gaucher Disease

Platelet Count [britannica.com] Serum Decreased Platelet Count [en.wikipedia.org] Serum Decreased Platelet Count Decreased platelet counts (thrombocytopenia) as well as low [symptoma.com]

Decreased platelet counts (thrombocytopenia) as well as low hemoglobin (anemia) and decreased white blood cell counts (leukopenia) result in easy bruisability and hence black-and-blue [scientificamerican.com]

[…] blood cell count causing anemia Individuals with anemia may have fatigue, low energy, and decreased exercise tolerance Decreased platelet count can cause easy bruising Bone [dovemed.com]

Hypersplenism

Splenic volume decreased from 1,400 to 470 cm3. The platelet count increased to almost normal levels. No complications were observed. [ncbi.nlm.nih.gov]

Thrombocytopenia may exacerbate liver fibrosis ( 1, 2 ) and a severe decrease in platelet counts is a major risk factor of hypersplenism ( 3 ). [spandidos-publications.com]

By 36 months after operation peripheral platelet and white cell counts had decreased significantly in the RFA group compared with the splenectomy group, and declined to baseline [ncbi.nlm.nih.gov]

Acute Myeloid Leukemia with Myelodysplasia-Related Changes

platelet counts These symptoms may be observed in patients suffering from distinct types of acute myeloid leukemia, and the distinction of AML-MRC requires further analyses [symptoma.com]

It may reveal both an excess of white blood cells (leukocytosis) or a decrease (leukopenia), and a low red blood cell count (anemia) and low platelets (thrombocytopenia) can [en.wikipedia.org]

[…] marrow, symptoms may include: A pale complexion from anemia caused by a low red cell count Prolonged bleeding and easy bruising caused by a very low platelet count called thrombocytopenia [aamds.org]

Hemolytic Uremic Syndrome

platelet count Elevated blood urea nitrogen (BUN) and creatinine due to decreased kidney function Blood and protein in urine Presence of shiga toxin-producing E. coli in [davita.com]

The large amount of platelets used to promote clotting causes thrombocytopenia in the overall blood supply, with bruising and bleeding elsewhere in the body. [davita.com]

Disseminated Intravascular Coagulation

Diagnosis is based on presence of ≥1 known underlying conditions causing DIC plus abnormal global coagulation tests: decreased platelet count, increased prothrombin time, [bestpractice.bmj.com]

Blood tests revealed a decreased platelet count, disseminated intravascular coagulation (DIC), renal dysfunction, hemolysis, and infection. [ncbi.nlm.nih.gov]

Patients with DIC have: a low or rapidly decreasing platelet count prolonged global coagulation tests low plasma levels of coagulation factors and inhibitors increased markers [ashclinicalnews.org]

HELLP Syndrome

Despite considerable patient variation, most gravid women with HELLP syndrome had decreasing platelet counts until 24 to 48 hours after delivery. [ncbi.nlm.nih.gov]

Postoperatively, the platelet count and antithrombin III level decreased, and computed tomography revealed intramuscular hematomas that possibly were related to vascular injury [ncbi.nlm.nih.gov]

[…] organs, and ultimately, death. [6] [17] [27] Early signs of systemic complement-mediated TMA include thrombocytopenia (platelet count below 150,000 or a decrease from baseline [en.wikipedia.org]

Wiskott-Aldrich Syndrome

Diagnosis Presentation: Children 1-2 years present with easy bruising, bleeding tendencies, decreased platelet counts. Bacterial infection is also seen. [rarediseasesindia.org]

Eltrombopag treatment resulted in an increased platelet count in 5 out of 8 patients. [ncbi.nlm.nih.gov]

Immunoglobulin levels Platelet count and volume assessment White blood cell function tests (eg, neutrophil chemotaxis, T-cell function) Diagnosis of Wiskott-Aldrich syndrome [msdmanuals.com]

Paroxysmal Nocturnal Hemoglobinuria

RESULTS: We observed a decrease in platelet EV count with eculizumab treatment (p CONCLUSIONS: Eculizumab has an impact on the extent of EV production and on the procoagulant [ncbi.nlm.nih.gov]

[…] and decreased platelet counts may be seen at this. [en.wikipedia.org]

[…] in platelet count by 25% or more compared to baseline or the peak platelet count during Soliris treatment; an increase in serum creatinine by 25% or more compared to baseline [soliris.net]

Microangiopathic Hemolytic Anemia

Isolated decrease in red blood cells (hemoglobin) Anemia Isolated decrease in platelets Thrombocytopenia Isolated decrease in white blood cell count Leukopenia Decrease in [morningreporttgh.blogspot.com]

Platelet count 150,000-400,000 per microliter Decreased Nadir is usually 20,000-30,000 in MAHA but may decrease to under 10,000 in TTP-HUS. [clinicaladvisor.com]

count decreased. [ard.bmj.com]

Platelet-Type Bleeding Disorder 17

A 22-year-old male patient presenting with petechiae on his limbs was diagnosed with ITP due to a gradual decrease of his platelet count to a minimum of 26 × 10(9) /liter [ncbi.nlm.nih.gov]

Platelet count was decreased (33-150 X 10(9)/1) and small platelets were increased in platelet volume distribution. Bleeding time was prolonged on most occasions. [ncbi.nlm.nih.gov]

Splenectomy should be considered to increase the platelet counts in those whose platelet counts decrease to approximately 30,000/microliter. [rarediseases.info.nih.gov]

Pancytopenia

counts. [njlm.net]

Within 24 hours of the first dose of fidaxomicin and before the second dose, the patient's platelet count fell to 156,000 platelets/mm3, her hemoglobin concentration decreased [ncbi.nlm.nih.gov]

Decreased WBC and platelet counts were most likely due to thyrotoxicosis as these resolved with treatment of the problem. [bmcsurg.biomedcentral.com]

Post-Polycythemia Vera Myelofibrosis

Anagrelide may also be used to decrease platelet counts. Prognosis PV is a chronic disease. [orpha.net]

Treatment uses medicines to decrease the platelet count. In people with the JAK2 mutation, specific inhibitors of the JAK2 protein may be used, such as ruxolitinib. [rush.edu]

It is used only to decrease the platelet count where this causes ongoing symptoms and HU is ineffective or not tolerated. [mpncanada.com]

Secondary Myelofibrosis

platelet count, increased bone marrow fibrosis, older age, and longer duration of disease. [1], [10], [11], [12] We found no significant correlation of leukocytosis, higher [ijpmonline.org]

Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts (>1,000 x 10 9 /L) are associated with acquired von [clevelandclinicmeded.com]

M arvin and S pellberg [ 64 ] reported that cytoreductive therapy, by decreasing the platelet count, reversed PH and right heart failure in a 72-year-old patient with myeloid [err.ersjournals.com]

Fat Embolism

platelet counts Decreased red blood cell counts Elevated ESR (blood marker for inflammation) Fat macroglobulinemia (fat particles in the blood) Pneumonia and heart failure [parentprojectmd.org]

[decreased platelet count], anemia, and hypofibrinogenemia are indicative of fat embolism syndrome. [boneandspine.com]

[…] and/or chest) Minor Symptoms Tachycardia (fast heart rate, over 140s) Fever Retinal changes (hemorrhages or fat globules upon exam) Jaundice (yellowing of skin or eyes) Decreased [parentprojectmd.org]

Portal Cirrhosis

Reduced levels of platelets or decreased white blood cell count. Get useful, helpful and relevant health + wellness information enews More health news + info [my.clevelandclinic.org]

Reduced levels of platelets or decreased white blood cell count. Cleveland Clinic News & More Cleveland Clinic News & More [my.clevelandclinic.org]

When the spleen enlarges, the number (count) of white blood cells can decrease (increasing the risk of infections), and the number (count) of platelets can decrease (increasing [merckmanuals.com]

Primary Myelofibrosis

Early studies indicate that it can decrease symptoms, spleen size, anemia, platelet count and white blood cell count. [verywellhealth.com]

Ann Hematol, 77(6): 291-2 [ CR ] [ PM ] [ EČ ][ GS ] Shpilberg, O., Shimon, I., Sofer, O., Dolitski, M., Ben, I. (1996) Transient normal platelet counts and decreased requirement [scindeks.ceon.rs]

Rocky Mountain Spotted Fever

Age and decreased platelet count at presentation have been independently associated with the development of ARF by multivariate analysis. [emedicine.com]

Has been described in fatal cases of RMSF Factors at presentation associated with development of acute renal failure (ARF) include increased bilirubin, advancing age, thrombocytopenia [emedicine.com]