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43 Possible Causes for Decreased Platelet Count, Extremity Ataxia, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[] Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count.[]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[] FBC, clotting screen, renal testing and LFTs: Suspect excessive alcohol use if mean corpuscular volume (MCV) is raised and platelet count may be decreased or elevated liver[] Investigations Alcohol level is useful in acute comatose state: Alcohol level 300 mg/100 ml extreme intoxication (drowsiness and then coma).[]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[] ), ataxia and positive Babinski reflexes.[]

  • Castleman Disease

    Progressive motor polyneuropathy suggesting coexistent POEMS does not respond well to rituximab or to IL-6–targeted therapy, and these patients require autologous stem cell[] […] in association with a total ophtalmoplegia and a dysphagia, consistent with the Miller-Fisher syndrome (ophtalmoplegia, ataxia, and areflexia).[] The observed side effects were low platelet counts and low fibrin levels, with no macrophage activation syndrome ( Fig. 1 ) and an episode of herpes zoster.[]

  • Thiamine Deficiency

    […] voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.[] Laboratory results were significant for low platelet count of 71 000 per mm 3, slight elevation of prothrombin time/partial thromboplastin time and international normalized[] After 2 to 3 months apathy and weakness become extreme, calf muscle tenderness develops with loss of recent memory, confusion, ataxia, and sometimes persistent vomiting ([]

  • Acute Arsenic Poisoning

    In addition, non-inflammatory degenerative disease of the sensorimotor nerves (sensorimotor polyneuropathy) may advance to progressive deterioration (atrophy).[] […] jerks, tremors, seizures, an impaired ability to coordinate voluntary movements (ataxia), and/or inability to stand or walk.[] Some affected individuals may experience the loss of most or all of their scalp hair (alopecia); rapidly progressive and painful sensory polyneuropathy; motor neuropathy;[]

  • POEMS Syndrome

    Before the implementation of aPBSCT, the clinical course of POEMS syndrome was characterized by progressive polyneuropathy potentially leading to death for respiratory failure[] Neurologic examination revealed upper and lower extremity weakness with bilateral foot drop and gait ataxia requiring crutches for ambulation and bilateral foot braces.[] Hemoglobin was slightly decreased, with normal platelet and white blood cell counts. All symptoms indicated of a relapse. 4 Table 1.[]

  • Miller-Fisher Syndrome

    Chronic inflammatory demyelinating polyneuropathy (CIDP) CIDP is characterized by slowly progressive weakness over a period of at least two months, accompanied by hyporeflexia[] […] of strength in the extremities and trunk.[] The usual biological assessment (blood count-platelet count, blood crase, blood ionogram, renal and hepatic functions, ...), thyroid assessment returned normal.[]

  • Familial Infantile Myoclonic Epilepsy

    […] cerebellar atrophy and polyneuropathy 25728773,23224214,20118933 PNPO PNPO deficieny, neonatal epileptic encephalopathy 24645144 POLG POLG-related disorders: mitochondrial[] ; early infantile epileptic encephalopathy 13; Seizures, benign familial infantile, 5 AD 41 SCN9A 603415 primary erythermalgia; Paroxysmal extreme pain disorder; INDIFFERENCE[] , and one other experiencing a decreased white blood cell count There was also one child on LTG who developed Stevens-Johnson syndrome.[]

  • Wernicke Encephalopathy

    […] voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.[] Alcoholic patients had a significantly higher frequency of hyponatremia (P .04) and decreased platelet count (P .005) compared with nonalcoholics.[] The classic triad of Wernicke encephalopathy consists of altered consciousness, ophthalmoplegia, and ataxia.[]

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