Create issue ticket

43 Possible Causes for Decreased Platelet Count, Extremity Ataxia, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count.[labtestsonline.org]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[patient.info] FBC, clotting screen, renal testing and LFTs: Suspect excessive alcohol use if mean corpuscular volume (MCV) is raised and platelet count may be decreased or elevated liver[patient.info] Investigations Alcohol level is useful in acute comatose state: Alcohol level 300 mg/100 ml extreme intoxication (drowsiness and then coma).[patient.info]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org] ), ataxia and positive Babinski reflexes.[doi.org]

  • Castleman Disease

    Progressive motor polyneuropathy suggesting coexistent POEMS does not respond well to rituximab or to IL-6–targeted therapy, and these patients require autologous stem cell[hematology.org] […] in association with a total ophtalmoplegia and a dysphagia, consistent with the Miller-Fisher syndrome (ophtalmoplegia, ataxia, and areflexia).[karger.com] The observed side effects were low platelet counts and low fibrin levels, with no macrophage activation syndrome ( Fig. 1 ) and an episode of herpes zoster.[mct.aacrjournals.org]

  • Thiamine Deficiency

    […] voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.[ncbi.nlm.nih.gov] Laboratory results were significant for low platelet count of 71 000 per mm 3, slight elevation of prothrombin time/partial thromboplastin time and international normalized[stroke.ahajournals.org] After 2 to 3 months apathy and weakness become extreme, calf muscle tenderness develops with loss of recent memory, confusion, ataxia, and sometimes persistent vomiting ([wardelab.com]

  • Acute Arsenic Poisoning

    In addition, non-inflammatory degenerative disease of the sensorimotor nerves (sensorimotor polyneuropathy) may advance to progressive deterioration (atrophy).[rarediseases.org] […] jerks, tremors, seizures, an impaired ability to coordinate voluntary movements (ataxia), and/or inability to stand or walk.[rarediseases.org] Some affected individuals may experience the loss of most or all of their scalp hair (alopecia); rapidly progressive and painful sensory polyneuropathy; motor neuropathy;[rarediseases.org]

  • POEMS Syndrome

    Before the implementation of aPBSCT, the clinical course of POEMS syndrome was characterized by progressive polyneuropathy potentially leading to death for respiratory failure[ncbi.nlm.nih.gov] Neurologic examination revealed upper and lower extremity weakness with bilateral foot drop and gait ataxia requiring crutches for ambulation and bilateral foot braces.[nature.com] Hemoglobin was slightly decreased, with normal platelet and white blood cell counts. All symptoms indicated of a relapse. 4 Table 1.[haematologica.org]

  • Miller-Fisher Syndrome

    Chronic inflammatory demyelinating polyneuropathy (CIDP) CIDP is characterized by slowly progressive weakness over a period of at least two months, accompanied by hyporeflexia[cancertherapyadvisor.com] […] of strength in the extremities and trunk.[hon.ch] The usual biological assessment (blood count-platelet count, blood crase, blood ionogram, renal and hepatic functions, ...), thyroid assessment returned normal.[oatext.com]

  • Familial Infantile Myoclonic Epilepsy

    […] cerebellar atrophy and polyneuropathy 25728773,23224214,20118933 PNPO PNPO deficieny, neonatal epileptic encephalopathy 24645144 POLG POLG-related disorders: mitochondrial[tests.labmed.washington.edu] ; early infantile epileptic encephalopathy 13; Seizures, benign familial infantile, 5 AD 41 SCN9A 603415 primary erythermalgia; Paroxysmal extreme pain disorder; INDIFFERENCE[centogene.com] , and one other experiencing a decreased white blood cell count There was also one child on LTG who developed Stevens-Johnson syndrome.[angelman.org]

  • Wernicke Encephalopathy

    […] voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.[ncbi.nlm.nih.gov] Alcoholic patients had a significantly higher frequency of hyponatremia (P .04) and decreased platelet count (P .005) compared with nonalcoholics.[ncbi.nlm.nih.gov] The classic triad of Wernicke encephalopathy consists of altered consciousness, ophthalmoplegia, and ataxia.[jaocr.org]

Similar symptoms