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17 Possible Causes for Decreased Platelet Count, Globulins Increased, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    count, platelet count and reticulocyte count (p   0.00, p   0.03, p   0.02, respectively).[ncbi.nlm.nih.gov] Hydroxyurea increases the concentration of fetal Hb (Hb F), decreases the leukocyte count, decreases the platelet count, and improves blood rheology.[clinicaladvisor.com] Benefits include increasing haemoglobin concentrations, and decreasing platelet and white cell counts. [ 1 ] Concerns remain about its myelosuppressive and teratogenic effects[patient.info]

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] , which is a decrease in platelets, the part of your blood that begins the clotting process inflammation of the heart complications that involve the nervous system, such as[healthline.com]

  • Chronic Active Hepatitis B

    In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] The positive anti-HCV antibody common in patients with IACAH is caused by disease related hypergammaglobulinemia and steroid therapy usually leads to decrease in gamma globulin[hepatitiscentral.com]

  • Precursor-Cell Lymphoblastic Leukemia

    Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] After 16 months, the results of routine blood tests showed reduced hemoglobin levels and decreased platelet counts.[ncbi.nlm.nih.gov] The bleeding in ALL is due to decreased platelet counts and occurs in the skin and mucosal surfaces, manifesting as purpura and ecchymosis .[lecturio.com]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Chronic Active Hepatitis

    Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] […] in blood platelet counts, % decrement of the platelet counts and elevation of serum triglyceride concentration after the IFN therapy were more remarkable with statistical[ci.nii.ac.jp]

  • Autoimmune Hepatitis

    More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] The patient will often rapidly improve and biopsy should be performed to confirm the diagnosis as soon as the prothrombin time decreases and platelet count increases to within[texasliver.com]

  • Pancytopenia

    […] levels of serum gamma globulin or IgG4; (iii) diffusely irregular narrowing of the main pancreatic duct on ERCP; (iv) fibrotic changes with lymphocyte infiltration on histology[smjonline.org] Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a noncompromised host; a case report of unusual entity.[scielo.br] counts.[njlm.net]

  • Severe Aplastic Anemia

    […] and cyclosporine increased response rates in patients with treatment-naive severe aplastic anemia.[healio.com] In virus-associated hemophagocytic syndrome with an acute parvovirus B19 infection, raised levels of cytokines such as interferon γ would impair regulation of the phagocytic[omicsonline.org] Transfusions are given when red cell counts decrease, patients with adequate platelet counts who have blood clots may receive blood thinners, and low white cell and platelet[marrowforums.org]

  • Adult Idiopathic Neutropenia

    RESULTS: We found that serum gamma-globulin, IgG and IgG1 levels were all significantly increased in the entire group of patients studied, compared to controls (p CONCLUSION[ncbi.nlm.nih.gov] syndrome Hemophagocytic syndrome associated with an infection Hepatic veno-occlusive disease-immunodeficiency syndrome Hereditary neutrophilia Hereditary periodic fever syndrome[se-atlas.de] […] in a decreased platelet count.[emedicine.medscape.com]

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