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219 Possible Causes for Decreased Platelet Count, Hypercellular Bone Marrow

  • Leukemia

    Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA , but can also be severe.[imbruvica.com] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[bloodjournal.hematologylibrary.org] If the PNH occurs in the setting of known (or suspected) aplastic anemia, abnormal white blood cell counts and decreased platelet counts may be seen at this.[en.wikipedia.org] RESULTS: We observed a decrease in platelet EV count with eculizumab treatment (p CONCLUSIONS: Eculizumab has an impact on the extent of EV production and on the procoagulant[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Postoperative markedly elevated platelet count was maintained up to 6 months, and after that, platelet count gradually decreased to normal values.[ncbi.nlm.nih.gov] At the age of 10 months after confirming stability of platelet counts, tapering betamethasone resulted in gradually decreasing hemoglobin levels and platelet counts (hemoglobin[jhoonline.biomedcentral.com] count was 84   10 9 /l.[bmcresnotes.biomedcentral.com]

  • Pernicious Anemia

    RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org] The differential white blood count shows a decrease in most types of cells but not lymphocytes.[labtestsonline.org] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] During treatment the leukocyte count decreased remarkably, and the patient developed lymphopenia together with a paradoxical increase in her blood platelet count.[ncbi.nlm.nih.gov] There developed an abrupt decrease in IgG and the absence of M-spike in serum immunoelectrophoresis. The platelet count kept normal during 1 year follow-up.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] As her platelet count decreased by cytoreductive therapy, complete hemostasis was achieved.[ncbi.nlm.nih.gov] Basophilia, increased or decreased platelet counts, and cytogenetic progression may also be observed.[nature.com]

  • Autoimmune Hemolytic Anemia

    Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[jmedicalcasereports.com] Median absolute reticulocyte counts decreased from 236 to 109 x 10(9)/L (P .01).[ncbi.nlm.nih.gov] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com] Leukemia • CBC and blood film examination : - Normocytic normochromic anemia (mild to severe) - Platelets count: reduced to normal - WBC’s count: decreased mature leukocytes[slideshare.net]

  • Cooley's Anemia

    RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org]

  • Sickle Cell Disease

    count, platelet count and reticulocyte count (p   0.00, p   0.03, p   0.02, respectively).[ncbi.nlm.nih.gov] Hydroxyurea increases the concentration of fetal Hb (Hb F), decreases the leukocyte count, decreases the platelet count, and improves blood rheology.[clinicaladvisor.com] Benefits include increasing haemoglobin concentrations, and decreasing platelet and white cell counts. [ 1 ] Concerns remain about its myelosuppressive and teratogenic effects[patient.info]

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