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205 Possible Causes for Decreased Platelet Count, Hypercellular Bone Marrow

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] There developed an abrupt decrease in IgG and the absence of M-spike in serum immunoelectrophoresis. The platelet count kept normal during 1 year follow-up.[ncbi.nlm.nih.gov] A major increase of the white blood cell count to over 50,000, platelet counts that are increased or decreased and red blood cell levels that are low despite treatment.[texasoncology.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] […] and decreased platelet counts may be seen at this.[en.wikipedia.org] Concerned with the apparent intravascular hemolysis, a bone marrow biopsy showed hypercellularity and normal cytogenetics.[medbullets.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] As her platelet count decreased by cytoreductive therapy, complete hemostasis was achieved.[ncbi.nlm.nih.gov] Basophilia, increased or decreased platelet counts, and cytogenetic progression may also be observed.[nature.com]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com] Leukemia • CBC and blood film examination : - Normocytic normochromic anemia (mild to severe) - Platelets count: reduced to normal - WBC’s count: decreased mature leukocytes[slideshare.net]

  • Acute Lymphoblastic Leukemia

    The leukemic cells of the hypercellular bone marrow then spill into the blood circulation and are visible on routine CBCs .[lecturio.com] After 16 months, the results of routine blood tests showed reduced hemoglobin levels and decreased platelet counts.[ncbi.nlm.nih.gov] These may include a mild increase or decrease in white blood cell count or some suppression in any or all lineages of red cells, white cells, and platelets.[clinicaladvisor.com]

  • Felty's Syndrome

    bone marrow.[ncbi.nlm.nih.gov] A flare-up of arthritis and a decrease in platelet counts were observed.[ncbi.nlm.nih.gov] A flare-up of arthritis and a decrease in platelet counts were observed. 1994 S.[karger.com]

  • Hereditary Spherocytosis

    Postoperative markedly elevated platelet count was maintained up to 6 months, and after that, platelet count gradually decreased to normal values.[ncbi.nlm.nih.gov] At the age of 10 months after confirming stability of platelet counts, tapering betamethasone resulted in gradually decreasing hemoglobin levels and platelet counts (hemoglobin[jhoonline.biomedcentral.com] count was 84   10 9 /l.[bmcresnotes.biomedcentral.com]

  • Wiskott Aldrich Syndrome

    The bone marrow was hypercellular with dysplasia.[ncbi.nlm.nih.gov] Diagnosis Presentation: Children 1-2 years present with easy bruising, bleeding tendencies, decreased platelet counts. Bacterial infection is also seen.[rarediseasesindia.org] Eltrombopag treatment resulted in an increased platelet count in 5 out of 8 patients.[ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    marrow biopsy and aspirate may show a hypercellular bone marrow with a megaloblastic maturation of cells, which morphologically resembles changes of vitamin B12 deficiency[pathologyoutlines.com] Significant blood test findings include macrocytosis, decreased reticulocyte count, abnormal platelets, and a serum folate less than 4 mg/ml.[innvista.com] Bone marrow aspirate and biopsy: Marrow is hypercellular with characteristic features of megaloblastic erythropoiesis and presence of large metamyelocytes.[clinicaladvisor.com]

  • Hairy Cell Leukemia

    Fig. 2: TRAP ; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm Cytology description Small / intermediate size cells with[pathologyoutlines.com] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com] Decreased white cell production increases the risk of infection. Low platelet counts result in bleeding or excessive bruising.[symptoma.com]

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