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521 Possible Causes for Decreased Platelet Count, Jaundice, Pallor

  • Hereditary Spherocytosis

    This case also highlights the fact that physicians should consider concomitant hemolytic disease in patients in whom jaundice and infections that rarely cause jaundice coexist[ncbi.nlm.nih.gov] Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] Postoperative markedly elevated platelet count was maintained up to 6 months, and after that, platelet count gradually decreased to normal values.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Jaundice: There is mild jaundice caused by the excessive breakdown of hemoglobin due to ineffective erythropoiesis in the bone marrow.[symptoma.com] Abstract Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org]

  • Autoimmune Hemolytic Anemia

    Secondary AIHA might not be diagnosed appropriately because the obstructive jaundice observed in type 1 AIP/IgG4-SC can obscure the presence of hemolytic jaundice.[ncbi.nlm.nih.gov] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Median absolute reticulocyte counts decreased from 236 to 109 x 10(9)/L (P .01).[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com] If the PNH occurs in the setting of known (or suspected) aplastic anemia, abnormal white blood cell counts and decreased platelet counts may be seen at this.[en.wikipedia.org]

  • Septicemia

    Jaundice What other disease/condition shares some of these symptoms?[clinicaladvisor.com] count that decreased to less than 30,000 per cubic millimeter and remained at that level despite standard therapy, traumatic injury of a blood vessel, or traumatic injury[content.nejm.org] […] accumulation Impaired oxygenation PaO 2 /FIO 2 Mechanical ventilation with low tidal volume and PEEP Liver Disturbed intracellular and extracellular bile salt transport Jaundice[doi.org]

  • Cooley's Anemia

    Children develop life-threatening anemia, have failure to thrive, and may develop jaundice.[secure.ssa.gov] The anemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatigability, failure to thrive (grow), bouts of fever[medicinenet.com] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org]

  • Sickle Cell Disease

    Jaundice, or yellowing of the skin, eyes, and mouth. Jaundice is a common sign and symptom of sickle disease.[hopkinsmedicine.org] ASS: Inquire about noticeable increase in weakness or pallor, syncope, and sudden abdominal distention.[web.archive.org] count, platelet count and reticulocyte count (p   0.00, p   0.03, p   0.02, respectively).[ncbi.nlm.nih.gov]

  • Fetal Erythroblastosis

    They can range from mild anemia and jaundice to fetal death in utero .[medindia.net] SignsMother• Polyhydramnios in mother.Baby• Pallor • Hepatosplenomegaly – signifying active haemolysis• Jaundice MAY NOT be there at birth – since the mother’s kidney will[de.slideshare.net] Clinical signs of severe haemolytic disease are pallor, hepatosplenomegaly, oedema, petechiae and ascites.[patient.info]

  • Gaucher Disease

    […] but jaundice is a poor prognostic indicator).[symptoma.com] […] reactions, occurring in 2 or more patients, included abdominal pain, agitation, fever, chills, diarrhea, eczema, edema, hypertension, irritability, laryngeal edema, nausea, pallor[aetna.com] Investigations General assessment FBC and differential (assess the degree of pancytopenia); LFTs (minor elevations of liver enzymes are common but jaundice is a poor prognostic[patient.info]

  • Hemolytic Uremic Syndrome

    A week later, he presents to the ER with jaundice, abdominal pain, and easy bruising. Lab results come back with low platelet count, anemia, and increased creatinine.[step2.medbullets.com] However, eight days post delivery, the patient developed severe nausea and vomiting followed by hematuria, spontaneous bruising, marked pallor, icteric sclera, and lethargy[ncbi.nlm.nih.gov] This results in platelet activation endothelial cell damage, and white blood cell activation, leading to systemic TMA, which manifests as decreased platelet count, hemolysis[en.wikipedia.org]

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