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1,843 Possible Causes for Decreased Platelet Count, Jaundice, Pallor, Thrombocytopenia

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov] […] disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor[medical-dictionary.thefreedictionary.com] […] and decreased platelet counts may be seen at this.[en.wikipedia.org]

  • Pernicious Anemia

    Jaundice: There is mild jaundice caused by the excessive breakdown of hemoglobin due to ineffective erythropoiesis in the bone marrow.[symptoma.com] This is the second description of pernicious anemia associated with autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org]

  • Malaria

    A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] […] describ the case of a young soldier who, after returning from Central Africa, presented a fever associated with petechial purpura and gingivorrhagia, hemogram showed deep thrombocytopenia[ncbi.nlm.nih.gov] Infant presented with pallor, jaundice and massive spleen. Laboratory tests revealed anaemia, thrombocytopenia and bilirubinemia.[ncbi.nlm.nih.gov] Common physical findings include jaundice, hepatosplenomagaly and pallor.[clinicaladvisor.com]

  • Atypical Hemolytic Uremic Syndrome

    These might include acute kidney failure, end-stage kidney disease, liver malfunction (leading to jaundice), clot formation leading to damage to the heart (heart attack) and[dovemed.com] A 28-day-old female presented with gross hematuria and hypertension. aHUS was suspected based on anemia with schistocytes, thrombocytopenia, low C3, and acute kidney injury[ncbi.nlm.nih.gov] Symptoms Signs and symptoms of HUS can include: Bloody diarrhea Decreased urination or blood in the urine Abdominal pain, vomiting and occasionally fever Pallor Small, unexplained[mayoclinic.org] platelet count, and hemolytic anemia with schizocytes.[ncbi.nlm.nih.gov]

  • Microangiopathic Hemolytic Anemia

    A newborn infant with a large hepatic hemangioma developed congestive heart failure, consumption coagulopathy, microangiopathic hemolytic anemia, and obstructive jaundice.[ncbi.nlm.nih.gov] In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[ncbi.nlm.nih.gov] -sudden pallor -black urine then oliguria (low urine output) then anuria How do you diagnose hemolytic uremia syndrome?[quizlet.com] Isolated decrease in red blood cells (hemoglobin) Anemia Isolated decrease in platelets Thrombocytopenia Isolated decrease in white blood cell count Leukopenia Decrease in[morningreporttgh.blogspot.com]

  • ALK+ Histiocytosis

    After noticing he appeared jaundiced, doctors did a blood test and discovered his platelet count was 18,000, significantly lower than the average count of 150,000.[medium.com] , metabolic/storage diseases, hematopoietic malignancies, and autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] General pathology Genetic and developmental anomalies ALK histiocytosis See also histiocytoses ALK immunoreactivity Clinical synopsis pallor massive hepatosplenomegaly anemia[humpath.com] The organs decrease functionality as they enlarge, and red blood cells and platelet counts decrease.[eu.wausaudailyherald.com]

  • Acute Lymphoblastic Leukemia

    A 30-year-old pregnant woman presented at 16 weeks' gestation with epistaxis, jaundice, diffuse abdominal pain and distension, massive hepatosplenomegaly and peripheral oedema[ncbi.nlm.nih.gov] This bleeding is commonly attributed to thrombocytopenia due to bone marrow suppressive chemotherapeutic agents.[ncbi.nlm.nih.gov] […] leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor[merriam-webster.com] After 16 months, the results of routine blood tests showed reduced hemoglobin levels and decreased platelet counts.[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    Obstructive jaundice: an unusual initial manifestation of intra-abdominal non-Hodgkin lymphoma in a child.[journals.lww.com] Additionally, the effects of reduced red blood cell count (anemia) and thrombocytes (thrombocytopenia) present with fatigue, easy bruising and bleeding.[symptoma.com] There was moderate pallor, bilateral, multiple, discrete, soft cervical lymph nodes with largest measuring up to 2 cm.[henrypublishinggroups.com] Signs and symptoms Signs and symptoms of ALL include the following: Fever Signs and symptoms of anemia, such as pallor, fatigue, dizziness, palpitations, cardiac flow murmur[emedicine.medscape.com]

  • Chronic Lymphocytic Leukemia

    Swelling and a yellow pigment of the skin (jaundice) may also occur. The National Cancer Institute has published a six-step description of the staging of this disorder.[rarediseases.org] There is no or little evidence of anemia or thrombocytopenia.[symptoma.com] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com]

  • Hemolytic Uremic Syndrome

    A week later, he presents to the ER with jaundice, abdominal pain, and easy bruising. Lab results come back with low platelet count, anemia, and increased creatinine.[step2.medbullets.com] Laboratory analyses identified microangiopathic hemolytic anemia (MHA) and thrombocytopenia.[ncbi.nlm.nih.gov] However, eight days post delivery, the patient developed severe nausea and vomiting followed by hematuria, spontaneous bruising, marked pallor, icteric sclera, and lethargy[ncbi.nlm.nih.gov] platelet count Elevated blood urea nitrogen (BUN) and creatinine due to decreased kidney function Blood and protein in urine Presence of shiga toxin-producing E. coli in[davita.com]

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