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15 Possible Causes for Decreased Platelet Count, Leukocyte Alkaline Phosphatase Increased, Normocytic Normochromic Anemia

  • Multiple Myeloma

    […] typically normochromic/normocytic renal failure proteinuria hypercalcemia Presentation may also be with a complication, including: pathological fracture vertebral compression[radiopaedia.org] Decreases in blood cell counts. DARZALEX can decrease white blood cell counts which help fight infections and blood cells called platelets which help to clot blood.[darzalex.com] […] absolute neutrophil count, decreased phosphorus, anemia, neutropenia, decreased total white blood cell count, decreased platelets, diarrhea, fatigue, thrombocytopenia, pyrexia[investors.amgen.com]

  • Hodgkin's Disease

    BACKGROUND: Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so[…][ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Blood counts generally reveal normocytic, normochromic anemia, leukopenia, and thrombocytopenia.[symptoma.com]

  • Aplastic Anemia

    Read More on This Topic blood disease: Normocytic normochromic anemias In aplastic anemia the normally red marrow becomes fatty and yellow and fails to form enough of its[britannica.com] After 11 cycles of PEM maintenance therapy, the patient's platelet count decreased, and progressed to pancytopenia within two months.[ncbi.nlm.nih.gov] normochromic anemia, inadequate reticulocyte response Constitutional aplastic anemia Generally, only 3 clinically significant disorders: Fanconi anemia , dyskeratosis congenita[pathologyoutlines.com]

  • Primary Myelofibrosis

    alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] Normocyticnormochromic anemia is present in most, but not all, patients (see Table 91–2). 7–15,262–265 Mean hemoglobin concentration in a series of patients at diagnosis[patient-help.com] Platelet counts initially may be high, normal, or decreased; however, thrombocytopenia tends to supervene as the disorder progresses.[merck.com]

  • Myelodysplasia

    The anemia was normochromic and normocytic in seven patients. Neutropenia was present in seven patients.[ncbi.nlm.nih.gov] People may also develop symptoms related to a decrease in the platelet or white blood cell count, such as infections (decreased white blood cell count), and easy bruising[oncolink.org] Thrombocytopenia The platelet count is often decreased with abnormal platelets.[patient.info]

  • Acute Erythroblastic Leukemia

    Bone marrow aspirate Peripheral Blood Per the CBC, the peripheral blood reveals a severe normochromic, normocytic anemia with circulating nucleated RBCs.[academic.oup.com] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com] […] bone marrow function, particularly susceptibility to infection due to the predominance of immature and abnormally functioning white blood cells, bleeding tendency owing to decreased[medical-dictionary.thefreedictionary.com]

  • Leukoerythroblastic Anemia

    alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] normochromic anemia, reticulocytopenia, and bone marrow erythroblastopenia.[ncbi.nlm.nih.gov] Platelets can be increased, decreased, or normal (megakaryocytic fragments are seen occasionally in the blood).[mhmedical.com]

  • Liver Failure

    Blood examination and imaging revealed a decreased platelet count and splenomegaly.[ncbi.nlm.nih.gov] Other complications from cirrhosis include: bruising (due to low platelet count and/or poor clotting) bleeding (due to decreased clotting proteins) sensitivity to medications[healthline.com]

  • Agranulocytosis

    Peripheral smear showed normocytic normochromic anemia with Rouleaux formation, leucopenia with 2% atypical cells and mild thrombocytosis.[ncbi.nlm.nih.gov] DIAGNOSIS AND CLINICAL PRESENTATION Agranulocytosis is characterized by a neutrophil granulocyte count 0.5 109/l with no relevant decrease in haemoglobin and platelet counts[flipper.diff.org] Routine investigations were done which showed anemia, neutropenia, leucopenia and high CRP (C reactive protein) [ Table 1 ].[ncbi.nlm.nih.gov]