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195 Possible Causes for Decreased Platelet Count, Macrocytic Anemia

  • Pernicious Anemia

    Macrocytic anemia incidiously appeared in September 1999.[] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[] Abstract An elderly black man was admitted to our institution with macrocytic anemia, dysphagia, and significant weight loss.[]

  • Folate-Deficiency Anemia

    Definition / general Folate deficiency is a low level of folic acid (Vitamin B9) in the body Essential features Characterized by macrocytic anemia Terminology Also called[] Significant blood test findings include macrocytosis, decreased reticulocyte count, abnormal platelets, and a serum folate less than 4 mg/ml.[] […] a form of megaloblastic (macrocytic) anemia caused by a lack of folic acid in the diet. folic acid deficiency anemia Anemia resulting from a deficiency of folic acid.[]

  • Vitamin B12 Deficiency

    Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[] Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count .[] Abstract Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[]

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[] Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts ( 1,000 x 10 9 /L) are associated with acquired von[] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([] If the PNH occurs in the setting of known (or suspected) aplastic anemia, abnormal white blood cell counts and decreased platelet counts may be seen at this.[] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[] platelet count, and anemia due to decreased erythrocyte count.[] An excellent example was case 352 Image 1D , a 20-year-old man who had jaundice and severe macrocytic anemia.[]

  • Chronic Alcoholism

    Macrocytosis with an MCV 100 fL reflects the direct effect of alcohol on bone marrow as well as macrocytic anemia resulting from folate deficiency, which is common among undernourished[] FBC, clotting screen, renal testing and LFTs: Suspect excessive alcohol use if mean corpuscular volume (MCV) is raised and platelet count may be decreased or elevated liver[] Other diseases include scurvy , resulting from vitamin C deficiency; hypochromic macrocytic anemia, caused by folate deficiency, vitamin B 12 deficiency, or certain chemotherapeutic[]

  • Severe Aplastic Anemia

    If cell size is much smaller than normal, it is known as microcytic anemia. If it is much bigger than normal, then it is macrocytic anemia.[] Transfusions are given when red cell counts decrease, patients with adequate platelet counts who have blood clots may receive blood thinners, and low white cell and platelet[] Diamond-Blackfan anemia Diamond-Blackfan anemia (DBA) is characterized by a normochromic macrocytic anemia that can be isolated, or it can be associated with growth retardation[]

  • Diphyllobothrium Latum Infection

    C Produces macrocytic anemia due to B12 deficiency a. Diphyllobothrium is an example of the genera under Pseudophyllidea.[] anemia ("tapeworm anemia") secondary to vitamin B12 deficiency (3) decreased serum vitamin B12 Often the infection is found incidentally when the patient is being worked[] In Diphyllobothrium latum infection, true: A Definitive host is Cyclops B Infective agent is metacercaria C Produces macrocytic anemia due to B12 deficiency D All are true[]

  • Primary Myelofibrosis

    Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts ( 1,000 x 10 9 /L) are associated with acquired von[] Platelet counts initially may be high, normal, or decreased; however, thrombocytopenia tends to supervene as the disorder progresses.[] , when the platelet count is decreased to less than 600 x 10 9 /L. 46 Some have postulated that maintaining a platelet count less than 400 x 10 9 /L may be associated with[]

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