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209 Possible Causes for Decreased Platelet Count, Macrocytic Anemia

  • Vitamin B12 Deficiency

    Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org] Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count.[labtestsonline.org] Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Other diseases include scurvy, resulting from vitamin C deficiency; hypochromic macrocytic anemia, caused by folate deficiency, vitamin B 12 deficiency, or certain chemotherapeutic[britannica.com] FBC, clotting screen, renal testing and LFTs: Suspect excessive alcohol use if mean corpuscular volume (MCV) is raised and platelet count may be decreased or elevated liver[patient.info] Macrocytosis with an MCV 100 fL reflects the direct effect of alcohol on bone marrow as well as macrocytic anemia resulting from folate deficiency, which is common among undernourished[merckmanuals.com]

  • Pernicious Anemia

    Macrocytic anemia incidiously appeared in September 1999.[ncbi.nlm.nih.gov] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org] An elderly black man was admitted to our institution with macrocytic anemia, dysphagia, and significant weight loss.[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] People may also develop symptoms related to a decrease in the platelet or white blood cell count, such as infections (decreased white blood cell count), and easy bruising[oncolink.org] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Folate-Deficiency Anemia

    Definition / general Folate deficiency is a low level of folic acid (Vitamin B9) in the body Essential features Characterized by macrocytic anemia Terminology Also called[pathologyoutlines.com] Significant blood test findings include macrocytosis, decreased reticulocyte count, abnormal platelets, and a serum folate less than 4 mg/ml.[innvista.com] […] a form of megaloblastic (macrocytic) anemia caused by a lack of folic acid in the diet. folic acid deficiency anemia Anemia resulting from a deficiency of folic acid.[medical-dictionary.thefreedictionary.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] If the PNH occurs in the setting of known (or suspected) aplastic anemia, abnormal white blood cell counts and decreased platelet counts may be seen at this.[en.wikipedia.org] Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption); Anemia - intrinsic factor; Anemia[mclaren.org]

  • Bone Metastasis

    Magnetic resonance (MR) imaging-guided focused ultrasound is an alternative noninvasive method for reducing the pain in skeletal metastases. MR imaging-guided focused ultrasound ablation offers several key advantages over other noninvasive treatment modalities. This technology enables the performance of[…][ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts ( 1,000 x 10 9 /L) are associated with acquired von[clevelandclinicmeded.com] Platelet counts initially may be high, normal, or decreased; however, thrombocytopenia tends to supervene as the disorder progresses.[merck.com] ., Ben, I. (1996) Transient normal platelet counts and decreased requirement for interferon during pregnancy in essential thrombocythaemia.[scindeks.ceon.rs]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com] An excellent example was case 352 Image 1D, a 20-year-old man who had jaundice and severe macrocytic anemia.[academic.oup.com]

  • Severe Aplastic Anemia

    If cell size is much smaller than normal, it is known as microcytic anemia. If it is much bigger than normal, then it is macrocytic anemia.[labtestsonline.org] Transfusions are given when red cell counts decrease, patients with adequate platelet counts who have blood clots may receive blood thinners, and low white cell and platelet[marrowforums.org] Diamond-Blackfan anemia Diamond-Blackfan anemia (DBA) is characterized by a normochromic macrocytic anemia that can be isolated, or it can be associated with growth retardation[emedicine.medscape.com]

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