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186 Possible Causes for Decreased Platelet Count, Normocytic Normochromic Anemia

  • Autoimmune Hemolytic Anemia

    Signs and Symptoms Pallor Jaundice Lethargy Abdominal pain Low-grade fever Dark urine (sever hemolysis) Hepatosplenomegaly Diagnostic tests CBC with smear Normocytic, normochromic[] RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[] anemia Reticulocytosis (or rare reticulocytopenia) Spherocytes, schistocytes, poikilocytes, polychromasia Normal WBC and Platelets (except in Evan’s syndrome) DAT (Direct[]

  • Paroxysmal Nocturnal Hemoglobinuria

    […] and decreased platelet counts may be seen at this.[] We observed a decrease in platelet EV count with eculizumab treatment (p 0.05).[] […] in platelet count by 25% or more compared to baseline or the peak platelet count during Soliris treatment; an increase in serum creatinine by 25% or more compared to baseline[]

  • Chronic Kidney Insufficiency

    Hyperphosphatemia and hyperparathyroidism are common findings, whereas a complete blood count (CBC) reveals anemia with normochromic and normocytic characteristics, thus excluding[] Anemia Normochromic normocytic anemia principally develops from decreased renal synthesis of erythropoietin, the hormone responsible for bone marrow stimulation for red blood[]

  • Acute Leukemia

    Leukemia • CBC and blood film examination : - Normocytic normochromic anemia (mild to severe) - Platelets count: reduced to normal - WBC’s count: decreased mature leukocytes[] platelet count, and anemia due to decreased erythrocyte count.[] These may include a mild increase or decrease in the WBC count or some suppression in any or all lineages of red cells, white cells, and platelets.[]

  • Atypical Hemolytic Uremic Syndrome

    Biochemistry revealed: normocytic normochromic anemia (Hb 6 g/dL); platelet count 132 10 9 L 1 , acute kidney injury (Urea 81 mmol/L; Creatinine 1487 μmol/L); high Lactate[] platelet count, and hemolytic anemia with schizocytes.[] […] cells (cells that line the blood vessels), and white blood cell activation, leading to systemic TMA, which manifests as decreased platelet count, hemolysis (breakdown of[]

  • Acute Myelocytic Leukemia

    Anemia It is primarily a normocytic normochromic anemia, which typically increases on induction chemotherapy. It is to be managed with recurrent blood transfusion.[] platelet count, and anemia due to decreased erythrocyte count.[] Complications of Acute Myeloid Leukemia Bleeding and Anemia alongside AML The most common complications associated with AML include anemia, infection and bleeding while neutropenic[]

  • Hypersplenism

    Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[] Platelet counts decrease during G-CSF administration. Platelets entering the spleen are cleared rapidly from the blood stream in the hypersplenic state.[] Splenic volume decreased from 1,400 to 470 cm3. The platelet count increased to almost normal levels. No complications were observed.[]

  • Acute Monocytic Leukemia

    Anemia It is primarily a normocytic normochromic anemia, which typically increases on induction chemotherapy. It is to be managed with recurrent blood transfusion.[] […] in platelets , red blood cells , or even with a low white blood cell count ( leukopenia ). [26] While a presumptive diagnosis of AML can be made by examination of the peripheral[] Bleeding Bleeding is present due to the decreased platelet counts or due to DIC. DIC is predominantly seen in acute promyelocytic leukemia (M3).[]

  • Aplastic Anemia

    Read More on This Topic blood disease: Normocytic normochromic anemias In aplastic anemia the normally red marrow becomes fatty and yellow and fails to form enough of its[] After 11 cycles of PEM maintenance therapy, the patient's platelet count decreased, and progressed to pancytopenia within two months.[] normochromic anemia, inadequate reticulocyte response Constitutional aplastic anemia Generally, only 3 clinically significant disorders: Fanconi anemia , dyskeratosis congenita[]

  • Hairy Cell Leukemia

    , normochromic anemia, rarely aplastic anemia due to infiltration of BM, spleen, lymph nodes; 10% have platelet counts of 20 x 109/L–US: 20,000/mm3, 20% have thrombocytosis[] Decreased white cell production increases the risk of infection. Low platelet counts result in bleeding or excessive bruising.[] She had splenomegaly and lymphocytosis (lymphocyte count of 11.6 10 9 /l), with remarkably abnormal appearing morphology. Her hemoglobin and platelet counts were normal.[]

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