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14 Possible Causes for Decreased Platelet Count, Polyclonal Hyperglobulinemia

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] The observed side effects were low platelet counts and low fibrin levels, with no macrophage activation syndrome ( Fig. 1 ) and an episode of herpes zoster.[mct.aacrjournals.org] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[scielo.br]

  • Primary Myelofibrosis

    Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com] Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts ( 1,000 x 10 9 /L) are associated with acquired von[clevelandclinicmeded.com] Platelet counts initially may be high, normal, or decreased; however, thrombocytopenia tends to supervene as the disorder progresses.[merck.com]

  • Chronic Active Hepatitis B

    hyperglobulinemia.[hepatitiscentral.com] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • Chronic Active Hepatitis

    hyperglobulinemia.[hepatitiscentral.com] […] in blood platelet counts, % decrement of the platelet counts and elevation of serum triglyceride concentration after the IFN therapy were more remarkable with statistical[ci.nii.ac.jp] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • Multicentric Castleman's Disease

    hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] According to the clinical history there was decrease in the platelet count.[elsevier.es] count (thrombocytopenia) Elevated lymphocytes and plasma cells (polyclonal lymphocytosis and plasmacytosis) Elevated BUN and creatinine (decreased kidney function) Proteinuria[cdcn.org]

  • Biliary Cirrhosis

    All forms of PBC: IgM Typical: ALK-P & GGT , ALT/AST PBC with AIH features: ALT/AST , IgG Late phase: thrombocytopenia, polyclonal hyperglobulinemia, and hyperbilirubinemia[slideshare.net] Monitoring Noninvasive tests can be used at baseline and for monitoring (EASL, 2017) Bilirubin ALP AST Albumin Platelet count Elastography Consider transplant assessment evaluation[arupconsult.com] […] infiltration or lymphoma Screening Screening of first-degree relatives of affected individuals using ALT with reflex to AMA may be indicated; however, there is no data to support decreased[arupconsult.com]

  • Angioimmunoblastic Lymphadenopathy

    In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] Throughout the course of the disease, platelet count decrease and CIC increment was documented.[diagnosticpathology.biomedcentral.com] As the disorder progresses, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia may develop.[emedicine.medscape.com]

  • Congenital Intrinsic Factor Deficiency

    NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] Vit.B12 is given parenterally at a dose of 1mg- followup shows decrease in MCV,reticulocytosis and improvement in platelet and neutrophil counts.[slideshare.net] Hepatic granuloma Uveoparotid fever [Heerfordt] D86.9 Sarcoidosis, unspecified D89 Other disorders involving the immune mechanism, not elsewhere classified [ edit ] Excludes1: hyperglobulinemia[en.wikisource.org]

  • Hyperglobulinemic Purpura

    Other immunologic abnormalities include a polyclonal hyperglobulinemia and positive tests for cryoglobulins; these cryoglobulins may contain monoclonal IgMK proteins.[enotes.tripod.com] Treatment with AZT frequently alleviates the condition. (09 Oct 1997) purpura, thrombocytopenic Any form of purpura in which the platelet count is decreased.[kmle.co.kr] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Idiopathic Cryoglobulinemia

    NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] Many patients had a decrease in white-cell and platelet counts of 10 to 20 percent; 13 patients lost their appetites and had a slight weight loss.[nejm.org] […] polymorphonuclear neutrophils ( D71 ) human immunodeficiency virus [HIV] disease ( B20 ) D89 Other disorders involving the immune mechanism, not elsewhere classified Excludes1 hyperglobulinemia[icd10coded.com]

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