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27 Possible Causes for Deep Groove of Philtrum

  • Mowat-Wilson Syndrome

    An individual with MWS may also have: Deep set, widely spaced eyes; Characteristic ear shape with a turned-up ear lobe; Broad nasal tip and short philtrum (the vertical central[specialeducationalneeds.co.uk] Typical facial features that include: deep-set, widely-spaced eyes thick eyebrows characteristic ear shape with a turned-up ear lobe broad nasal tip and short philtrum (the[contact.org.uk] groove from the nose to the upper lip); Small open mouth with a highly arched palate; Prominent chin.[specialeducationalneeds.co.uk]

  • Noonan Syndrome

    Noonan syndrome presents with distinctive facial features, such as: A deep philtrum (groove between the nose and mouth) Hypertelorism (widely spaced eyes) Low-set ears rotated[dermnetnz.org] People with Noonan syndrome often have some of the following features: Facial features (most obvious in babies and children and more subtle in adults): A deep groove in the[stjude.org] Abnormal facial features include a deep groove in the area between the mouth and nose (philtrum), widely spaced eyes that are strikingly blue or blue-green in color, low-set[symptoma.com]

  • Vaginal Atresia

    These features including deep-set, widely-spaced eyes with downward-slanting lid folds, a flat nasal bridge with nostrils that flare forward, and a long groove (philtrum)[rarediseases.org]

  • SHORT Syndrome

    People with Noonan syndrome have distinctive facial features such as a deep groove in the area between the nose and mouth ( philtrum ), widely spaced eyes that are usually[ghr.nlm.nih.gov]

  • Central Polydactyly of Toes

    These features including deep-set, widely-spaced eyes with downward-slanting lid folds, a flat nasal bridge with nostrils that flare forward, and a long groove (philtrum)[rarediseases.org]

  • Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 3

    Dysmorphic features included brachycephaly, high forehead with bitemporal narrowing, depressed nasal bridge, long philtrum with a deep groove, and open mouth due to hypotonia[bio2rdf.org]

  • Sanjad-Sakati Syndrome

    […] eyes Blue sclera Low-set ears Large forehead Beaked or sharp nose Long philtrum (groove below the nose) Thin lips External ear abnormalities Depressed nasal bridge Diagnosis[forgottendiseases.org] […] often share a similar facial appearance, with characteristics as follows: Facial features in Sanjad-Sakati syndrome Micrognathia (small jaw) Microphthalmia (small eyes) Deep-set[forgottendiseases.org]

  • Short stature-Valvular Heart Disease-Characteristic Facies Syndrome

    groove in the area between the nose and mouth (philtrum), widely spaced eyes that are usually pale blue or blue-green in color, and low-set ears that are rotated backward[icdlist.com] […] stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.People with Noonan syndrome have distinctive facial features such as a deep[icdlist.com]

  • Mulibrey Nanism Syndrome

    groove in the area between the nose and mouth (philtrum), widely spaced eyes that are usually pale blue or blue-green in color, and low-set ears that are rotated backward[icdlist.com] […] stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.People with Noonan syndrome have distinctive facial features such as a deep[icdlist.com]

  • Weaver Syndrome

    Distinguishing features of Weaver syndrome include broad forehead and face, ocular hypertelorism, prominent wide philtrum, micrognathia, deep horizontal chin groove, and deep-set[uniprot.org] , micrognathia, deep horizontal chin groove, and deep-set nails.[diseaseinfosearch.org] […] overlap between Weaver syndrome and Sotos syndrome ({117550}), distinguishing features of Weaver syndrome include broad forehead and face, ocular hypertelorism, prominent wide philtrum[diseaseinfosearch.org]

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