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178 Possible Causes for Deep Set Eyes, High Forehead

  • Trisomy 12p

    His phenotype was similar to that of the "trisomy 12p syndrome", characterized by developmental delays and craniofacial abnormalities including a high forehead, a short nose[canceropole-est.org] Dysmorphic features may include everted lips, deep-set eyes, upslanting palpebral fissures, hypertelorism, synophris, prominent philtrum and hypotonic facies.[epilepsydiagnosis.org] The dysmorphic features included a board forehead with high anterior hairline, hypertelorism, flat nasal bridge, short upturned nose, down turned corners of the mouth, short[ashg.org]

  • Sanjad-Sakati Syndrome

    - High forehead - Hyperphosphtemia - Hypocalcemia - Hypoparathyroidy - Intellectual deficit / mental / psychomotor retardation / learning disability - Intrauterine growth[csbg.cnb.csic.es] All patients had severe intrauterine growth retardation, short stature, small hands and feet, blue sclera, deep-set eyes, microcephaly, persistent hypocalcaemia and hypoparathyroidism[ncbi.nlm.nih.gov] The clinical features include deep set eyes, microcephaly, thin lips, depressed nasal bridge with beaked nose, external ear anomalies and learning difficulties.[ncbi.nlm.nih.gov]

  • Alagille Syndrome

    Notes: Triangular appearance of the face with the high forehead, deep-set eyes with moderate hypertelorism, pointed chin, and saddle or straight nose with a bulbous tip.[dovepress.com] Besides causing neonatal jaundice, it affects many body systems and is associated with pulmonary valvular stenosis, peripheral pulmonary stenosis, deep-set eyes with anterior[medical-dictionary.thefreedictionary.com] […] pitched voice. pancreas : diabetes, exocrine pancreatic insufficiency. gut : small bowell atresia or stenosis. lung : tracheal and bronchial stenosis. face : prominent forehead[atlasgeneticsoncology.org]

  • Freeman-Sheldon Syndrome

    These features include an extremely small puckered mouth (microstomia); a “full” forehead appearance, unusually prominent cheeks; and thin, pursed lips.[courageousfacesfoundation.org] Other dysmorphic features include deep set eyes, broad nasal bridge, long philtrum and 'H' shaped cutaneous dimple on the chin.[ncbi.nlm.nih.gov] Freeman-Sheldon syndrome is defined as a combination of microstomia, deep set eyes, small palpebral fissures, arthrogryposis with ulnar deviation of the hand, talipes equinovarus[ncbi.nlm.nih.gov]

  • Monosomy 1p36 Syndrome

    […] foot 0001761 Polymicrogyria More grooves in brain 0002126 Prominent forehead Pronounced forehead Protruding forehead [ more ] 0011220 Self-mutilation Deliberate self-harm[rarediseases.info.nih.gov] Clinical findings were generalised obesity with a body mass index 95th centile, acanthosis nigricans of the neck, arms with self inflicted lesions, deep-set eyes, straight[ncbi.nlm.nih.gov] These features may include microcephaly (small head), which may be combined with brachycephaly (short head); small, deep-set eyes; straight eyebrows; epicanthal folds; a broad[en.wikipedia.org]

  • Mowat-Wilson Syndrome

    Abstract Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows[ncbi.nlm.nih.gov] Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin[uniprot.org] Clinical description The typical characteristic facies of MWS includes a high forehead, frontal bossing, large eyebrows that are medially flaring and sparse in the middle[orpha.net]

  • Zellweger Syndrome

    The common clinical findings included high forehead, large fontanelle, shallow orbit ridges, micrognathia, upslanting palebral fissures, epicanthal folds, severe hypotonia[ncbi.nlm.nih.gov] Patients with Lowe’s syndrome often exhibit typical facial determinants such as deep-set eyes, frontal bossing, chubby cheeks, as well as a fair complexion with a blonde hair[news-medical.net] Symptoms of these disorders include an enlarged liver; characteristic facial features such as a high forehead, underdeveloped eyebrow ridges, and wide-set eyes; and neurological[ninds.nih.gov]

  • Saethre-Chotzen Syndrome

    forehead (56 percent), ptosis (53 percent), and prominent auricular crura (56 percent).[ncbi.nlm.nih.gov] […] and widely set eyes, open mouth, wide nasal bridge and a shortened philtrum .[en.academic.ru] Other symptions include: Head/Face: abnormally shaped head a high forehead a low frontal hair line facial asymmetry palatal anomalies [4] Eyes/Nose/Ears: droopy eyes (ptosis[pfond.cmmt.ubc.ca]

  • Autosomal Dominant Hyper-IgE Syndrome

    Distinctive facial appearances may include prominent forehead and chin, deep-set eyes, broad noses, and high arched palate.[columbiadoctors.org] Facial changes such as facial asymmetry, broad nose, and deep-set eyes with a prominent forehead, facial skin thickening with prominent pores occur during adolescence.[radiopaedia.org] […] abscesses Severe recurrent respiratory infections that may lead to chronic respiratory problems Distinctive facial appearance - rough skin, facial asymmetry, prominent forehead, deep-set[cpi.org.au]

  • Smith-Magenis Syndrome

    Several features appear to be age-dependent, including prominent forehead, prognathism, brachycephaly, hoarse voice, and ophthalmologic findings, specifically high myopia[priory.com] The face is characterized by a short flat head, prominent forehead, broad square face, upslanting eye slits, deep-set eyes, underdeveloped midface, broad nasal bridge, short[medicinenet.com] […] developmental delay hypotonia hyporeflexia lethargy feeding difficulties Physical features facial appearance specific and changes over time square face brachycephaly full cheeks deep-set[en.wikibooks.org]

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