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13 Possible Causes for Deep Vein Thrombosis, Lactate Dehydrogenase Increased, Vaso-Occlusive Crisis

  • Sickle Cell Disease

    Patients with sickle cell disease have a baseline hypercoaguable state and are at a greater risk forming deep vein thrombosis and pulmonary embolism than the general population[ncbi.nlm.nih.gov] The condition was therefore interpreted as a massive intestinal vaso-occlusive crisis or "girdle syndrome".[ncbi.nlm.nih.gov] It has been shown that sickle cell patients have a higher prevalence of pulmonary thrombosis but not deep vein thrombosis compared to age- and race-matched controls, suggesting[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] The patient exhibits biological signs of intravascular hemolysis, as well as a recent history of two episodes of deep vein thrombosis.[ncbi.nlm.nih.gov] […] dL and can exceed 1.0 g/dL during severe hemolytic episodes. 42 Similarly, plasma hemoglobin levels range from 0.001 to 0.033 g/dL in SCD and can exceed 0.041 g/dL during vaso-occlusive[jama.ama-assn.org]

  • Anticardiolipin Antibody Syndrome

    A peripheral blood smear can identify schistocytes (red blood cell fragments) seen in patients with TTP, along with evidence of hemolysis (increased LDH [lactate dehydrogenase[cancertherapyadvisor.com] Continued Deep vein thrombosis ( DVT ) is a blood clot that commonly occurs in the deep veins of the leg (the ones closest to the bones), which carry a lot of blood to the[webmd.com] This leads to several complications, including: Blood clots in veins: DVT (deep vein thrombosis) Blood clots in arteries: strokes and heart attacks Miscarriages Low platelet[resources.lupus.org]

  • Sickle Cell Crisis

    Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) Sickling of red cells can increase blood coagulation and induce an increased risk of blood clot in a deep vein (DVT)[cdc.gov] Trottier, Nancy Robitaille, Yves Pastore, Marie-Joelle Dore Bergeron and Benoit Bailey , Oral morphine protocol evaluation for the treatment of vaso-occlusive crisis in paediatric[doi.org] A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. [1] [2] It is a form of sickle cell crisis.[en.wikipedia.org]

  • Hematoma

    Deep vein thrombosis of the lower leg was identified and edoxaban, a so-called novel oral anticoagulant, was started on postoperative day 7.[ncbi.nlm.nih.gov] He was diagnosed as having orbital compression syndrome secondary to vaso-occlusive crisis of sickle cell disease and was treated with intravenous ampicilin-sulbactam and[ncbi.nlm.nih.gov]

  • HELLP Syndrome

    Although a significant trend was apparent in increasing levels of lactate dehydrogenase, aspartate aminotransferase, and uric acid as HELLP syndrome worsened, there was considerable[ncbi.nlm.nih.gov] New symptoms of APS, including deep vein thrombosis and ischemic nervus opticus lesion, developed in the patient followed by the onset of acute respiratory distress syndrome[ncbi.nlm.nih.gov] Fijnvandraat , Dynamics of von Willebrand factor reactivity in sickle cell disease during vasoocclusive crisis and steady state , Journal of Thrombosis and Haemostasis ,[doi.org]

  • Thalassemia

    At the end of the treatment period, Hb and HbF increased by 2.5   1.8 g/dL and 2.5   1.6 g/dL, while bilirubin, lactate dehydrogenase, and the nucleated red blood cell count[ncbi.nlm.nih.gov] More distinctive symptoms of this form include thrombosis of the deep veins, presenting as: leg thrombosis portal vein thrombosis stroke or embolism.[news-medical.net] Despite having mild anemia and high fetal hemoglobin level postinfancy, these patients developed many of the classic complications of SCD, including vaso-occlusive crisis,[ncbi.nlm.nih.gov]

  • Red Blood Cell Disorder

    Deep venous thrombosis: A blood clot in a deep vein, usually in the leg.[calcuttayellowpages.com] Sickle cell crisis, an acute condition occurring in patients with sickle-cell disease, include: vaso-occlusive crisis, splenic sequestration crisis, aplastic crisis, and hemolytic[courses.lumenlearning.com] A deep vein thrombosis (DVT) is a blood clot that develops in a deep vein, usually a leg vein.[patient.info]

  • Thyroid Crisis

    […] glycogenolysis, evolving into hypoglycemia when glycogen stores are depleted Elevated aspartate aminotransferase (AST), bilirubin and lactate dehydrogenase (LDH) Hypercalcemia[en.wikipedia.org] A patient who experienced thyroid storm complicated by rhabdomyolysis, deep vein thrombosis, and a silent pulmonary embolism: a case report.[emedicine.medscape.com] It can be a result of encephalitis or a reaction to antipsychotic medications. tabetic crisis a painful paroxysm occurring in tabes dorsalis. vaso-occlusive crisis a sickle[medical-dictionary.thefreedictionary.com]

  • Splenic Infarction

    Associated symptoms, leukocytosis or increased serum lactate dehydrogenase occurred inconsistently ( 25% each).[ncbi.nlm.nih.gov] Deep vein thrombosis or pulmonary embolism is more common in immunocompetent patients while splenic infarct is more common in immunocompromised patients.[ncbi.nlm.nih.gov] We describe a 19-year-old male with HbS-HPFH who had no history of anemia or vaso-occlusive crisis, who presented with a massive splenic infarct.[ncbi.nlm.nih.gov]

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