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192 Possible Causes for Deep White Matter Changes, Dementia, Dysarthria

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] […] small cerebral arteries Ataxia Autosomal recessive inheritance Babinski sign Dementia Diffuse demyelination of the cerebral white matter Diffuse white matter abnormalities Dysarthria[familydiagnosis.com] Clinically, Lacunar Dementia presents with gait difficulties, urinary incontinence, parkinsonian features, pseudobulbar palsy, emotional incontinence and dementia.[ncbi.nlm.nih.gov]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Dysarthria is more prevalent in left than in right hemisphere lesions.[ncbi.nlm.nih.gov] Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.[ncbi.nlm.nih.gov]

  • Cerebral Thrombosis

    Bilateral or widespread superficial dural sinus thrombosis with focal cortical or subcortical white matter infarction, often hemorrhagic Deep sinus thrombosis with thalamic[clinicaladvisor.com] People who drink more than this run a higher risk of stroke, high blood pressure, liver disease and dementia.[netdoctor.co.uk] […] to call 911 Urgent medical attention is needed if anyone has symptoms of a cerebrovascular attack, because it can have long-term effects, such as cognitive impairment and dementia[medicalnewstoday.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] He developed dysarthria, difficulty with his gait and dystonia in his arms at the age of 28 years.[ncbi.nlm.nih.gov] Serial assessments of a 29-year-old woman showed progressive dementia.[ncbi.nlm.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] We report the case of a 42-year-old man with a 5-year history of gait disturbance, dysarthria and cognitive impairment and familial antecedents of dementia and movement disorders[ncbi.nlm.nih.gov] Dementias: Advances in Neurology. 38 Vol. New York, NY: Raven; 1983. Meiser B, Dunn S.[web.archive.org]

  • Pseudobulbar Palsy

    Blahak C, Baezner H, Pantoni L et al (2009) Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are[link.springer.com] Synonyms: 'bulbar palsy' - lower motor neurone dysarthria, neuromuscular dysarthria, atrophic bulbar paralysis; 'pseudobulbar palsy' - upper motor neurone dysarthria, spastic[patient.info] Recurrent stroke seems to be common in patients with APS and a first stroke, recurrent stroke and vascular dementia are feared consequences of APS.[ncbi.nlm.nih.gov]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] She had spastic dysarthria. External ocular movements were full without nystagmus. Other cranial nerves and fundi were normal.[neurologyindia.com] Stroke is the third leading cause of death, and vascular dementia the second cause of dementia after Alzheimer's disease.[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] CASE PRESENTATION: We report a case of 59-year-old Asian woman with blurred vision, dysarthria, myoclonus, and rapidly progressive dementia.[ncbi.nlm.nih.gov] Abstract Creutzfeldt-Jakob disease (CJD) is a rare prion disease that leads to a rapidly progressive dementia (RPD) and associated neurological features.[ncbi.nlm.nih.gov]

  • Herpes Simplex Encephalitis

    The frontal dysexecutive syndrome and personality change could be explained by the involvement of frontal lobe white matter and the sensory symptoms, diplopia, and increased[jamanetwork.com] Abstract A very challenging problem in the domain of the cognitive neurosciences is to explain why herpes simplex encephalitis and semantic dementia show, respectively, a[ncbi.nlm.nih.gov] At discharge on hospital day 25, the patient had residual dysarthria and mild word-finding difficulties but no other neurological deficits.[karger.com]

  • Ataxia Telangiectasia

    Occasionally, lesions that are consistent with small vessel ischemic or degenerative changes have been noted in the deep white matter of the cerebral hemispheres.[appliedradiology.com] AT manifests as ataxia, apraxia, telangiectasia, and dysarthria. Common ophthalmologic findings in AT include fine conjunctival telangiectasia.[ncbi.nlm.nih.gov] Ataxia-telangiectasia usually progresses to paralysis, dementia, and death, typically by age 30.[merckmanuals.com]

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