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47 Possible Causes for Deep White Matter Changes, Dementia, EEG Generalized Slowing

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] CONCLUSIONS: Abnormal EEG in general and generalized slowing in particular are associated with clinical deterioration after acute ischemic stroke.[ncbi.nlm.nih.gov] Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.[ncbi.nlm.nih.gov]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] The neurological disease complex associated with virus infection occurs in a large proportion of infected patients and is commonly referred to as HIV-1 associated dementia[ncbi.nlm.nih.gov] Infection of the nervous system by HIV-1 commonly causes a broad range of cognitive, behavioral, and motor abnormalities called, in its most severe form, HIV-1-associated dementia[ncbi.nlm.nih.gov]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] […] as a public health priority; increasing awareness of dementia and establishing dementia-friendly initiatives; reducing the risk of dementia; diagnosis, treatment and care[who.int] Memory loss is a common symptom of dementia. However, memory loss by itself does not mean you have dementia.[web.archive.org]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] The EEG showed irregular background activity with generalized slow waves which were not suppressed with diazepam injection.[ncbi.nlm.nih.gov] Onset of dementia before 65 years of age is termed as young-onset dementia (YOD).[ncbi.nlm.nih.gov]

  • Toxic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] , and alcoholic dementia.[ncbi.nlm.nih.gov] What Is Dementia From Toxic Substances?[dementia.org]

  • Varicella-Zoster Virus Encephalitis

    Imaging shows multiple deep-seated ischemic or demyelinating lesions in neural white matter.[journals.lww.com] We studied the rare case of an older adult with dementia following herpes zoster encephalitis (HZE).[ncbi.nlm.nih.gov] D’Antona R, Baron JC, Samson Y, Serdaru M, Viader F, Agid Y, Cambier J (1985) Subcortical dementia.[link.springer.com]

  • Limbic Encephalitis

    Three patients without temporal–limbic MRI findings had white matter abnormalities in other regions: 1 multifocal, 1 diffuse, and 1 perithalamic and deep white matter changes[doi.org] Ten (10/18) patients had temporal lobe epileptic activity with or without general slowing on EEG.[ncbi.nlm.nih.gov] Most diagnostic imagers are familiar with the classic patterns of altered metabolism seen in Alzheimer disease, frontal temporal dementia, and dementia with Lewy bodies.[ncbi.nlm.nih.gov]

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org] Independent of adjusting factors, hyponatremia patients had 2.36-fold higher chances of suffering dementia, including Alzheimer's disease (AD) and non-AD dementia, than the[ncbi.nlm.nih.gov] Stroke is notorious for doubling the risk of suffering dementia (post-stroke dementia), including both AD and non-AD dementia[ 37 ].[journals.plos.org]

  • Meningoencephalitis

    Nevertheless, autopsy of the patient revealed frank ischemic changes (subacute infarcts) in the deep hemispheric white matter ( Fig 3 G ).[ajnr.org] Continuous EEG monitoring in the neurologic intensive care unit showed generalized background slowing and frequent spike-and-wave activity.[jamanetwork.com] We illustrated a 53-year-old man diagnosed with dementia. Neuroimaging and cerebrospinal fluid studies disclosed meningoencephalitis.[ncbi.nlm.nih.gov]

  • Vascular Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Prominent posterior slow-wave activity on EEG with periodic fluctuations in the pre-alpha/ theta range.[indianjpsychiatry.org] Vascular dementia (VaD) is the second most common cause of dementia and its prevalence increases after the sixth decade of life.[symptoma.com]

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