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191 Possible Causes for Deep White Matter Changes, Dementia, Irritability

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] […] forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability[ninds.nih.gov] Clinically, Lacunar Dementia presents with gait difficulties, urinary incontinence, parkinsonian features, pseudobulbar palsy, emotional incontinence and dementia.[ncbi.nlm.nih.gov]

  • Multi-Infarct Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Forgetfulness (but not as severe as Alzheimer's disease) Urinary incontinence Difficulty walking Clumsiness Changes in personality or mood (most likely in the form of apathy, irritability[alzheimers.emedtv.com] Mixed dementia consists of a combination between multi-infarct and Alzheimer's dementia.[symptoma.com]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] We present the case of a 34-year-old Jordanian woman who was referred to mainstream mental health services because of irritability, agitation, loss of appetite, withdrawal[ncbi.nlm.nih.gov] […] as a public health priority; increasing awareness of dementia and establishing dementia-friendly initiatives; reducing the risk of dementia; diagnosis, treatment and care[who.int]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] In multivariate regression analyses, both suicidal ideation and suicidal behavior were associated with a depressed mood, and to a lesser extend to irritability.[ncbi.nlm.nih.gov] Dementias: Advances in Neurology . 38 Vol. New York, NY: Raven; 1983. Meiser B, Dunn S.[web.archive.org]

  • Marchiafava Bignami Disease

    white matter microstructural changes on MRI in relation to early-stage atherosclerosis.[med.u-fukui.ac.jp] There were no lateralizing deficits and no signs of meningeal irritation.[indianjpsychiatry.org] The Cerebral Metabolic Rate of Glucose (CMRGlu) was measured with positron emission tomography and 18F-FDG in a patient with Marchiafava-Bignami Disease (MBD)-related dementia[ncbi.nlm.nih.gov]

  • Globoid Cell Leukodystrophy

    CONCLUSION: Cerebellar white matter and deep gray matter involvement are present only in early-onset GLD.[ncbi.nlm.nih.gov] The classic presentation includes excessive irritability, muscle hypertonicity, developmental delay, failure to thrive, peripheral neuropathy, seizures, and optic nerve atrophy[ncbi.nlm.nih.gov] Patients with late-onset forms, including adult onset, may present with blindness, spastic paraparesis, and dementia.[medlink.com]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] Other clinical manifestations were progressive gait problems, language deterioration, presence of primitive reflexes and irritability.[ncbi.nlm.nih.gov] Abstract Creutzfeldt-Jakob disease (CJD) is a rare prion disease that leads to a rapidly progressive dementia (RPD) and associated neurological features.[ncbi.nlm.nih.gov]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] The initial symptoms of SSPE are subtle and include mild mental deterioration (such as memory loss) and changes in behavior (such as irritability) followed by disturbances[ninds.nih.gov] Onset of dementia before 65 years of age is termed as young-onset dementia (YOD).[ncbi.nlm.nih.gov]

  • Huntington Disease-Like 2

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Irritability: For severe anger and threatening behavior, experts agree that an atypical antipsychotic drug is the preferred approach.[alz.org] We report on a South African family that presented with progressive dementia and a movement disorder affecting numerous family members.[ncbi.nlm.nih.gov]

  • Alcohol Dementia

    The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[gponline.com] Increased irritability, no emotional response at all, discomfort with being alone, inappropriate behavior in public. Difficulty in communicating with others.[luxury.rehabs.com] All about dementia types of dementia risk factors for dementia causes of dementia symptoms of dementia diagnosis of dementia dementia treatments long term dementia care alcohol-related[neurology.health-cares.net]

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