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218 Possible Causes for Deep White Matter Changes, Dementia, Seizure

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] Clinton suffers from “Dementia, Seizures and Black-outs.” In fact, the Doctor made note that Clinton’s conditions are “considerably worse” than in 2013.[globalresearch.ca] Clinically, Lacunar Dementia presents with gait difficulties, urinary incontinence, parkinsonian features, pseudobulbar palsy, emotional incontinence and dementia.[ncbi.nlm.nih.gov]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Twenty patients (40%) had a single seizure, and most seizures (34, or 68%) were simple partial seizures or partial seizures with 2 generalization.[doi.org] Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.[ncbi.nlm.nih.gov]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] Concentrations of neurotransmitters and abnormal function can be seen in seizure disorders and Alzheimer's disease.[symptoma.com] The neurological disease complex associated with virus infection occurs in a large proportion of infected patients and is commonly referred to as HIV-1 associated dementia[ncbi.nlm.nih.gov]

  • Cerebral Thrombosis

    Bilateral or widespread superficial dural sinus thrombosis with focal cortical or subcortical white matter infarction, often hemorrhagic Deep sinus thrombosis with thalamic[clinicaladvisor.com] More than a third of them sustains seizures, with generalized seizures occurring more frequently than focal seizures. Many patients present with hemiparesis.[symptoma.com] People who drink more than this run a higher risk of stroke, high blood pressure, liver disease and dementia.[netdoctor.co.uk]

  • Cerebral Angiitis

    Radiologic signs such as nonspecific white matter changes, deep location of lesion, and irregular appearance of the vessel on angiogram are more commonly seen in PACNS cases[acrabstracts.org] She also developed seizures and MRA of her head revealed cerebral infarct, with findings suggestive of cerebral angiitis.[ncbi.nlm.nih.gov] Conditions in which dementia or cognitive impairment may occur but in which dementia has not been reported as the primary presenting feature, conditions in which the dementia[medlink.com]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] Electroencephalography demonstrated bifrontal slowing with left-sided emphasis, and captured two focal onset partial seizures with the clinical correlate of the syndrome described[ncbi.nlm.nih.gov] […] as a public health priority; increasing awareness of dementia and establishing dementia-friendly initiatives; reducing the risk of dementia; diagnosis, treatment and care[who.int]

  • Lafora Disease

    matter signal, Deep frontoparietal cerebral changes at 10 years of age Child onset: Weakness Clinical Weakness: Proximal; Symmetric Muscle size: Calf hypertrophy Subgroup[neuromuscular.wustl.edu] […] the seizure latency and duration.[academic.oup.com] It is suggested that this type of presenile dementia may be a presenile form of Lafora disease.[ncbi.nlm.nih.gov]

  • Diffuse Cerebral Sclerosis of Schilder

    change in the deep white matter.[doi.org] Clinical findings Onset at age 5 and 10 with reversal of neurologic milestones, seizures, ataxia, Addison's disease, degeneration of visual and auditory function.[medical-dictionary.thefreedictionary.com] The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy.[icd9data.com]

  • Herpes Simplex Encephalitis

    The frontal dysexecutive syndrome and personality change could be explained by the involvement of frontal lobe white matter and the sensory symptoms, diplopia, and increased[jamanetwork.com] Seizures did not recur in the next 6 months.[ncbi.nlm.nih.gov] Abstract A very challenging problem in the domain of the cognitive neurosciences is to explain why herpes simplex encephalitis and semantic dementia show, respectively, a[ncbi.nlm.nih.gov]

  • Tay-Sachs Disease

    MRI MRI is superior to CT in delineating deep white matter demyelination. Thalami may show changes consistent with calcification, best seen on T2* weighted sequences.[radiopaedia.org] The patients was a 3-year-old boy with psychomotor retardation and attacked by seizures since 8 months of age. On funduscopy, the maculla presented a cherry-red spot.[ncbi.nlm.nih.gov] Patient declines to dementia with seizures, with death by age 16 years.[patient.info]

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