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49 Possible Causes for Deep White Matter Changes, EEG Generalized Slowing

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] CONCLUSIONS: Abnormal EEG in general and generalized slowing in particular are associated with clinical deterioration after acute ischemic stroke.[ncbi.nlm.nih.gov] Background The background EEG may be normal or show focal slowing over the location of the stroke.[epilepsydiagnosis.org]

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org]

  • Meningoencephalitis

    Nevertheless, autopsy of the patient revealed frank ischemic changes (subacute infarcts) in the deep hemispheric white matter ( Fig 3 G ).[ajnr.org] Continuous EEG monitoring in the neurologic intensive care unit showed generalized background slowing and frequent spike-and-wave activity.[jamanetwork.com]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] In general, the EEG in metabolic encephalopathy is abnormal; background slowing is the most common pattern found ( 9 Hz) [ 5 ].[aneskey.com] In the cases of encephalopathy, EEG can register generalized slowing or suppression of the EEG reactivity, loss of fast rhythm with occurrence of diffuse slow activity (theta[neurologyindia.com]

  • Toxic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] In the cases of encephalopathy, EEG can register generalized slowing or suppression of the EEG reactivity, loss of fast rhythm with occurrence of diffuse slow activity (theta[neurologyindia.com] […] be registered, whereas in T2 sequence, diffuse edema in the cortical regions (in the form of hyperintensity of perirolandic and occipital regions) can be detected. [43] Deep[neurologyindia.com]

  • Varicella-Zoster Virus Encephalitis

    Imaging shows multiple deep-seated ischemic or demyelinating lesions in neural white matter.[journals.lww.com] […] deficits such as hemiplegia or blindness. 1,25 Small-vessel encephalitis is more commonly seen in immunocompromised patients who present with fever, headache, mental status changes[journals.lww.com]

  • Hypoxic-Ischemic Brain Injury

    There was high signal on T2 and restricted diffusion throughout the deep white matter, predominantly posteriorly.[academic.oup.com] Gloor et al. 16, investigated the location of structural pathology that produced localized, lateralized or generalized EEG slow activity.[scielo.br] […] shows slowing and there is a 50-70% decrease in cerebral metabolism Prognosis Influenced by age, general medical condition, etiology, clinical signs Certain clinical signs[maryland.ccproject.com]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] The EEG showed irregular background activity with generalized slow waves which were not suppressed with diazepam injection.[ncbi.nlm.nih.gov] EEG showed generalized periodic high amplitude sharp and slow wave complexes.[atmph.org]

  • Limbic Encephalitis

    Three patients without temporal–limbic MRI findings had white matter abnormalities in other regions: 1 multifocal, 1 diffuse, and 1 perithalamic and deep white matter changes[doi.org] Ten (10/18) patients had temporal lobe epileptic activity with or without general slowing on EEG.[ncbi.nlm.nih.gov] The EEG can show temporal or diffuse slowness, temporal spikes, and temporal or generalized focal seizure activity.[medintensiva.org]

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