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27 Possible Causes for Deep White Matter Changes, Impaired Judgement

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[]

  • Alcohol Dementia

    […] logical thinking on tasks which require planning, organising, common sense judgement and social skills Problems with balance Decreased initiative and spontaneity.[] The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[] Hallucinations Delusions Impaired memory Personality changes – ranging from depressed and withdrawn to excited and irritable.[]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[]

  • Dementia

    Common dementia signs and symptoms Memory loss Impaired judgement Difficulties with abstract thinking Faulty reasoning Inappropriate behavior Loss of communication skills[] It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[] Common dementia signs and symptoms include: Memory loss Impaired judgement Difficulties with abstract thinking Faulty reasoning Inappropriate behavior Loss of communication[]

  • Multi-Infarct Dementia

    Insight and judgement may be relatively well preserved.[] Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[] Periventricular and deep white matter changes on T 2 -weighted MRI that are excessive for age 2 … … 3. Focal changes in electroencephalographic studies 3 27 1 31.8 D.[]

  • Bipolar Disorder

    It affects memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement.[] white matter abnormalities in individuals with BD ( Vederine et al. 2011 ; Torgerson et al. 2012).[] Summary of structural changes in bipolar disorder Patients with bipolar disorder had lateral ventricular enlargement ( 17%) and increased rates of deep white matter hyperintensities[]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[] […] tract) and deep grey matter (thalamus) structures were significantly reduced during the treatment phase (P 0.02, corrected).[]

  • Normal Pressure Hydrocephalus

    White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[] White-matter changes: A distinction is drawn between periventricular and “deepwhite matter changes ( e49, e50 ); only the former are considered a sign of NPH.[] white matter.[]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[] […] be registered, whereas in T2 sequence, diffuse edema in the cortical regions (in the form of hyperintensity of perirolandic and occipital regions) can be detected. [43] Deep[]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[] Although all modalities capable of structural brain imaging will demonstrate morphological changes of Huntington disease, MRI has the greatest spatial and contrast resolution[]

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