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27 Possible Causes for Deep White Matter Changes, Impaired Judgement

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org]

  • Alcohol Dementia

    […] logical thinking on tasks which require planning, organising, common sense judgement and social skills Problems with balance Decreased initiative and spontaneity.[dementiagippsland.com.au] The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[gponline.com] Hallucinations Delusions Impaired memory Personality changes – ranging from depressed and withdrawn to excited and irritable.[healthhype.com]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org]

  • Dementia

    Common dementia signs and symptoms Memory loss Impaired judgement Difficulties with abstract thinking Faulty reasoning Inappropriate behavior Loss of communication skills[helpguide.org] It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] Common dementia signs and symptoms include: Memory loss Impaired judgement Difficulties with abstract thinking Faulty reasoning Inappropriate behavior Loss of communication[helpguide.org]

  • Multi-Infarct Dementia

    Insight and judgement may be relatively well preserved.[azpsychiatry.info] Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Periventricular and deep white matter changes on T 2 -weighted MRI that are excessive for age 2 … … 3. Focal changes in electroencephalographic studies 3 27 1 31.8 D.[doi.org]

  • Bipolar Disorder

    It affects memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement.[who.int] white matter abnormalities in individuals with BD ( Vederine et al. 2011 ; Torgerson et al. 2012).[ncbi.nlm.nih.gov] Summary of structural changes in bipolar disorder Patients with bipolar disorder had lateral ventricular enlargement ( 17%) and increased rates of deep white matter hyperintensities[doi.org]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] […] tract) and deep grey matter (thalamus) structures were significantly reduced during the treatment phase (P 0.02, corrected).[ncbi.nlm.nih.gov]

  • Normal Pressure Hydrocephalus

    White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[intechopen.com] White-matter changes: A distinction is drawn between periventricular and “deepwhite matter changes ( e49, e50 ); only the former are considered a sign of NPH.[ncbi.nlm.nih.gov] white matter.[ajnr.org]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] […] be registered, whereas in T2 sequence, diffuse edema in the cortical regions (in the form of hyperintensity of perirolandic and occipital regions) can be detected. [43] Deep[neurologyindia.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Although all modalities capable of structural brain imaging will demonstrate morphological changes of Huntington disease, MRI has the greatest spatial and contrast resolution[radiopaedia.org]

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