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119 Possible Causes for Deep White Matter Changes, Poor Coordination

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] […] involves being cleared by the doctor (who will be aware of relevant government regulations) as the stroke may have left subtle impairments, not always apparent, such as poor[brainfoundation.org.au] coordination, lack of awareness on one side, difficulties in judging distance, changes in vision (as visual field defects), difficulties in concentration and confusion between[brainfoundation.org.au]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] […] tract) and deep grey matter (thalamus) structures were significantly reduced during the treatment phase (P 0.02, corrected).[ncbi.nlm.nih.gov]

  • Multi-Infarct Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Periventricular and deep white matter changes on T 2 -weighted MRI that are excessive for age 2 … … 3. Focal changes in electroencephalographic studies 3 27 1 31.8 D.[doi.org]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning new information or making decisions.[ghr.nlm.nih.gov] ., involuntary movements, restlessness, fidgety, loss of balance, awkward gait, poor coordination, dysarthria) cognitive changes (e.g., memory loss, inability to multitask[memory.ucsf.edu]

  • Ataxia Telangiectasia

    Occasionally, lesions that are consistent with small vessel ischemic or degenerative changes have been noted in the deep white matter of the cerebral hemispheres.[appliedradiology.com] Ataxia refers to poor coordination and telangiectasia to small dilated blood vessels, both of which are hallmarks of the disease.[dbpedia.org] Poor coordination and trembling of the extremities may appear towards 9-10 years of age and worsen progressively. Choreoathetosis is quite common.[orpha.net]

  • Neonatal Adrenoleukodystrophy

    Individuals with CARASIL may develop a variety of symptoms relating to white matter involvement or leukoaraiosis (changes in deep white matter in the brain, which are observed[rarediseases.org] […] disabilities, seizures, difficulty swallowing, deafness, difficulty walking, poor coordination, and fatigue.[livingnaturallyonline.com] Other symptoms may include vision loss, learning disabilities, seizures, poorly articulated speech, difficulty swallowing, deafness, difficulty walking, poor coordination,[livingnaturallyonline.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    Cranial magnetic resonance imaging (MRI) showed bilateral symmetric signal changes on the periventricular deep white matter and increased micronodular contrast uptake on the[pediatricneurosciences.com]

  • Alexander Disease

    Brain magnetic resonance imaging (MRI) showed atrophy of the medulla oblongata and mild cervical cord atrophy, deep white matter abnormalities, periventricular rim, and signal[ncbi.nlm.nih.gov] These children may have excessive vomiting, difficulty swallowing and speaking, poor coordination, and loss of motor control.[ninds.nih.gov] Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination.[kennedykrieger.org]

  • Autosomal Recessive Spinocerebellar Ataxia 18

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement[uniprot.org] The hereditary ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech[flybase.org]

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