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44 Possible Causes for Deepening of Voice, Hoarseness, Pituitary Adenoma

  • Acromegaly

    BACKGROUND: In more than 98% of cases, acromegaly is due to a GH-secreting pituitary adenoma.[ncbi.nlm.nih.gov] Ultimately they cause considerable disability (aside from the need for larger rings, gloves, and shoes) including hoarseness , sleep apnea , joint pain, cardiovascular disease[medicinenet.com] , husky voice due to enlarged vocal cords and sinuses Severe snoring due to obstruction of the upper airway Impaired vision Headaches Enlarged tongue Pain and limited joint[mayoclinic.org]

  • Launois Syndrome

    […] context of pituitary adenoma or hyperplasia, which sits in an enlarged sella turcica.[symptoma.com] It is assumed to be caused by pituitary hyperplasia and chromophobe adenoma with excessive somatropin production. Males are more commonly affected.[whonamedit.com] Transnasal stereotactic surgery of pituitary adenomas concomitant with acromegaly. Stereotact Funct Neurosurg. 1995;65:184-86. Fröhlich A.[rarediseases.org]

  • Gigantism

    AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism[ncbi.nlm.nih.gov] Voice is hoarse and affected individuals have a plump, stocky body with pectus excavatum, thoracic scoliosis, hepatosplenomegaly, umbilical and/or inguinal hernias, broad[ncbi.nlm.nih.gov] […] of the voice in males Skin changes: Increased number of skin tags Oily skin and excessive sweating Increased tissue in the wrists can lead to nerve compression, which may[pituitary.ucla.edu]

  • Hypothyroidism

    The following potential causes should be considered [20, 21] : Pituitary adenoma Tumors impinging on the hypothalamus Lymphocytic hypophysitis Sheehan syndrome History of[emedicine.com] She presented to our hospital with sudden-onset general malaise, edema, and hoarseness with an elevated thyroid-stimulating hormone (373.3 μIU/ml) level and very low triiodothyronine[ncbi.nlm.nih.gov] Other common symptoms are dry skin and hair, decreased perspiration , puffy eyes, cold intolerance, deepening of the voice, decreased appetite but a tendency to gain weight[britannica.com]

  • Hyperpituitarism

    Pituitary Adenomas Since it is the significant cause of pituitary overactivity, pituitary adenomas are worth considering on its own.[healthhype.com] Symptoms and Signs The symptoms of the condition include headaches, double vision, excessive sweating, hoarseness, sleep apnea and muscle weakness.[medigest.uk] Other symptoms of acromegaly include joint aches thick, coarse, oily skin skin tags enlarged lips, nose, and tongue deepening of the voice due to enlarged sinuses and vocal[niddk.nih.gov]

  • Ovarian Androblastoma

    ., Cushing's disease, adrenal hyperplasia, pituitary adenoma, other causes of ovarian and adrenal androgen hypersecretion, intersexuality, medically induced androgenization[ncbi.nlm.nih.gov] Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne,[knowcancer.com] Additional signs include acne and hirsutism , voice deepening, clitoromegaly , temporal hair recession, and an increase in musculature. Serum testosterone level is high.[en.wikipedia.org]

  • Gigantism - Acromegaly

    After the successful selective resection of a pituitary adenoma, pituitary funcion usually remains intact.[fitzgeraldmd.com] […] hands, jaw, tongue, and glands in the skin, which leads to excessive sweating and body odor), weakness, fatigue, thickening of the skin, joint pain and swelling, headache, hoarseness[emaxhealth.com] The onset of the condition is very gradual and manifests with significant changes to the body leading to coarse facial features, deepening of the voice, enlargement of lips[smartypance.com]

  • Testosterone

    OBJECTIVE: Gonadotroph pituitary adenomas are common, but the overwhelming majority are classified as nonfunctioning adenomas.[ncbi.nlm.nih.gov] […] your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse[drugs.com] The testosterone hormone also deepens the voice during puberty, stimulates the growth of facial and body hair, increases sexual drive, and is responsible for sperm production[bodylogicmd.com]

  • Precocious Puberty in Males

    Chemotherapy or radiotherapy CNS tumors, such as pituitary adenoma, glioma, prolactinoma, craniopharyngioma, astrocytoma Idiopathic hypopituitarism,germ cell tumour,hypothalamichamartomas[lecturio.com] For males, these signs can be enlargement of the testes, pubic, underarm, or facial hair growth, rapid height growth, deepening of the voice, acne, and "mature" body odor.[pamf.org] Signs of precocious puberty Girls Breast development Vaginal bleeding Boys Enlargement of the testicles and penis Facial hair Deepening voice Both Boys and Girls Pubic or[hormone.org]

  • Pituitary Disorder

    Pituitary adenomas are the third most common intracranial tumor and arise from the pituitary gland.[california.providence.org] […] fingernails Coarseness, thinning of hair Late symptoms: Slow speech Dry, flaky skin Thickening of the skin Puffy face, hands, and feet Decreased hearing Thinning of eyebrows Hoarseness[uclahealth.org] Adults may experience joint pain, sleep apnea, a change in facial appearance, and a deepening voice.[intermountainhealthcare.org]

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