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426 Possible Causes for Defect in Dentin Maturation, Enlargement of Ankles, Flattening of the Talar Dome

  • X-Linked Hypophosphatemia

    , pectum carinatum, metaphyseal flaring of the wrists or ankles, genus varus, frontal bossing enlarges sutures and fotanels or craniotabes.[iofbonehealth.org] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov] Phenotype Rickets, osteomalacia, late dentition, tooth abscesses secondary to poor mineralization, bowing of lower extremities, enlarged costochondral junctions of the ribs[iofbonehealth.org]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    ARHR is caused by inactivating mutations in the DMP1 gene, which encodes Dentin matrix protein 1 and results in increased FGF 23 expression and defective osteocyte maturation[scielo.mec.pt]

    Missing: Flattening of the Talar Dome
  • Ankle Arthritis

    Relative radiographic contraindications to performing an ankle distraction include flattening of the talar dome, presence of greater than five degrees of valgus or varus deformity[faoj.org] , grinding sensation in ankle, enlargement of the ankle, swelling, and/or a change in the structural architecture of the ankle and/or foot.[bunionsurgeryny.com] In some cases, deformity and/or enlargement (spur) of the joint may be noted. X-rays may be ordered to evaluate the extent of the disease.[foothealthfacts.org]

    Missing: Defect in Dentin Maturation
  • Hypophosphatasia

    Affected children may have short stature with bowed legs or knock knees, enlarged wrist and ankle joints, and an abnormal skull shape.[ghr.nlm.nih.gov] TNAP was found to be highly expressed by mature odontoblasts, and Alpl(-/-) molar and incisor roots featured defective dentin mineralization, ranging from a mild delay to[ncbi.nlm.nih.gov] Children also may have a short stature with bowed legs of knock knees, enlarged wrists and ankle joints, and an abnormal skull shape.[blogs.longwood.edu]

    Missing: Flattening of the Talar Dome
  • Vitamin D Deficiency

    Its manifestations include: deformed legs, leading to bow legs and knock knees ribcage deformities, leading to a pigeon chest Enlarged growth plates at the wrists, ankles[news-medical.net] However, severe vitamin D deficiency may manifest as rickets with the below clinical features: Bony Signs - Swelling of wrists and ankles - Leg deformities (genu varum or[starship.org.nz] […] valgum) - Rachitic rosary in the chest wall ( enlarged costochondral joints) - Delayed tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes[starship.org.nz]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Iron Deficiency

    In marked anaemia, there may be tachycardia, a flow murmur, cardiac enlargement, ankle oedema and heart failure.[patient.info]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Lipedema

    Often, patients’ chief complaint is of swelling and enlargement of tissue around the ankle .[bestveintreatment.com] Major symptoms of lipedema include intense leg swelling that cause the legs to become enlarged from the ankles to the hips disproportionately from the rest of the body, and[eu.tennessean.com] […] seen extending from the hips to the ankles.[ncbi.nlm.nih.gov]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Hypertension

    […] an enlarged aorta.[emedicinehealth.com] Physical examination may include listening to the heart and lungs , feeling for pulse in the wrist and ankles, and feeling and listening to the abdomen looking for signs of[emedicinehealth.com]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Hypogonadism

    […] of breathing during sleep (rarely) Fluid buildup (edema) in ankles, feet and legs (rarely) Questions to ask your doctor What is the cause of my low testosterone?[hormone.org] Other possible risks of testosterone treatment include: A high red blood cell count Acne Breast enlargement An increase in prostate size Sleep apnea—the occasional stopping[hormone.org]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Tarsal Tunnel Syndrome

    Causes Direct or indirect trauma to the ankle Flat Feet or fallen arches Osteoarthritis Swelling caused due to an ankle sprain Enlarged or abnormal structure in the ankle,[orthotexas.com] Tarsal tunnel syndrome can be caused by: Flat feet: fallen arches and tilting of the heel to the outside can stretch the nerve along the inside of the ankle An enlarged mass[fortiusclinic.com] […] cysts or a bone spur, or swelling secondary to ankle sprain.[medicinenet.com]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome