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337 Possible Causes for Defect in Dentin Maturation, Enlargement of the Wrists, Flattening of the Talar Dome

  • X-Linked Hypophosphatemia

    , pectum carinatum, metaphyseal flaring of the wrists or ankles, genus varus, frontal bossing enlarges sutures and fotanels or craniotabes.[iofbonehealth.org] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov] Phenotype Rickets, osteomalacia, late dentition, tooth abscesses secondary to poor mineralization, bowing of lower extremities, enlarged costochondral junctions of the ribs[iofbonehealth.org]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    ARHR is caused by inactivating mutations in the DMP1 gene, which encodes Dentin matrix protein 1 and results in increased FGF 23 expression and defective osteocyte maturation[scielo.mec.pt]

    Missing: Flattening of the Talar Dome
  • Vitamin D Deficiency

    Its manifestations include: deformed legs, leading to bow legs and knock knees ribcage deformities, leading to a pigeon chest Enlarged growth plates at the wrists, ankles[news-medical.net] However, severe vitamin D deficiency may manifest as rickets with the below clinical features: Bony Signs - Swelling of wrists and ankles - Leg deformities (genu varum or[starship.org.nz] […] valgum) - Rachitic rosary in the chest wall ( enlarged costochondral joints) - Delayed tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes[starship.org.nz]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Hypophosphatasia

    TNAP was found to be highly expressed by mature odontoblasts, and Alpl(-/-) molar and incisor roots featured defective dentin mineralization, ranging from a mild delay to[ncbi.nlm.nih.gov] Affected children may have short stature with bowed legs or knock knees, enlarged wrist and ankle joints, and an abnormal skull shape.[ghr.nlm.nih.gov] Children also may have a short stature with bowed legs of knock knees, enlarged wrists and ankle joints, and an abnormal skull shape.[blogs.longwood.edu]

    Missing: Flattening of the Talar Dome
  • Congenital Clubbing

    Enlargement of the extremities due to periarticular and osseous proliferation as well as digital clubbing are common.[online.epocrates.com] dome flattening (suggesting that the primary bone deformity present at birth dictates the eventual result of treatment).[emedicine.medscape.com] Characterized by the combination of pachydermia (elephant-like skin), periostosis (swelling around the joints, especially the wrists and knees), and clubbing.[online.epocrates.com]

    Missing: Defect in Dentin Maturation
  • Ganglion Cyst

    Constantly using your hand or wrist can make the cyst enlarge and hurt more. Some hand and wrist movements, such as grasping things, may also be difficult.[broava.com] […] mass on the dorsum of his left wrist which has been present for 3 years.[orthobullets.com] Sorry, this question is for PEAK Premium Subscribers only Sorry, this question is for PEAK Premium Subscribers only (OBQ12.64) A 54-year-old male presents with a slowly enlarging[orthobullets.com]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Hypertension

    […] an enlarged aorta.[emedicinehealth.com] Physical examination may include listening to the heart and lungs , feeling for pulse in the wrist and ankles, and feeling and listening to the abdomen looking for signs of[emedicinehealth.com]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Atopy

    Because atopic dermatitis has many appearances, the differential diagnosis is broad ( Table 1 ). 7 Enlarge Print Figure 2.[aafp.org] Atopic dermatitis tends to involve the flexural surfaces of the body, anterior and lateral neck, eyelids, forehead, face, wrists, dorsa of the feet, and hands.[aafp.org]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Dermatitis

    In moderate cases the area enlarges to the back of the hands and the fingers.[doi.org] In severe cases the entire hands and the wrists can be affected, and there may also be pain or infection.[doi.org]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome
  • Atopic Dermatitis

    Because atopic dermatitis has many appearances, the differential diagnosis is broad ( Table 1 ). 7 Enlarge Print Figure 2.[aafp.org] Because atopic dermatitis has many appearances, the differential diagnosis is broad ( Table 1 ) . 7 Enlarge Print Figure 2.[aafp.org] Atopic dermatitis tends to involve the flexural surfaces of the body, anterior and lateral neck, eyelids, forehead, face, wrists, dorsa of the feet, and hands.[aafp.org]

    Missing: Defect in Dentin Maturation Flattening of the Talar Dome