Defective Enamel Formation: Causes & Reasons

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Possible Causes for Defective Enamel Formation

Costello Syndrome

MEK1/2 inhibition rescued the hypo-mineralized enamel, normalized the ameloblast polarity defect and restored normal progenitor cell proliferation. [ncbi.nlm.nih.gov]

We demonstrate for the first time the central role of Ras signaling in enamel formation in CS individuals and present the mouse incisor as a model system to dissect the roles [ncbi.nlm.nih.gov]

To determine through which pathway Ras affects enamel formation, inhibitors targeting either PI3K or MEK 1 and 2 (MEK 1/2), kinases in the MAPK pathway, were utilized. [ncbi.nlm.nih.gov]

Enamel Hypoplasia

Abstract A discrete area of defective enamel formation that appears on the labial surface of the crowns of deciduous canine teeth has been described in both recent and prehistoric [ncbi.nlm.nih.gov]

[…] is hard but thin and deficient in amount as a result of defective enamel matrix formation with a shortage of the cementing substance. [medical-dictionary.thefreedictionary.com]

Enamel hypoplasia is a defect of the teeth in which the enamel is deficient in amount, caused by defective enamel matrix formation. [en.wikipedia.org]

Amelogenesis Imperfecta Type 1E

UniProtKB/Swiss-Prot : 75 Amelogenesis imperfecta 1F: A form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. [malacards.org]

AI is characterized by the defect in enamel formation, resulting in defective mineralization or formation of the matrix. [ijsronline.net]

defective matrix formation causes the enamel to be normal in hardness but deficient in quantity; and in enamel hypocalcification, defective maturation of ameloblasts results [medical-dictionary.thefreedictionary.com]

Amelogenesis Imperfecta Type 1C

[…] is hard but thin and deficient in amount as a result of defective enamel matrix formation with a shortage of the cementing substance. [medical-dictionary.thefreedictionary.com]

[…] of enamel formation. [genecards.org]

A defect in collagen formation is probable. enamel layer the outermost layer of cells of the enamel organ. mottled enamel dental fluorosis; defective enamel, with a chalky [medical-dictionary.thefreedictionary.com]

Amelogenesis Imperfecta Type 2A5

Related phenotypes are carious teeth and amelogenesis imperfecta UniProtKB/Swiss-Prot : 75 Amelogenesis imperfecta, hypomaturation type, 2A5: A defect of enamel formation. [malacards.org]

[…] of enamel formation. [genecards.org]

[…] associations of SNPs for SLC24A4 - elite association - COSMIC cancer census association via MalaCards Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5) [MIM:615887]: A defect [genecards.org]

Amelogenesis Imperfecta Type 2A6

Definition A defect of enamel formation. The disorder involves both primary and secondary dentitions. [uniprot.org]

UniProtKB/Swiss-Prot : 73 Amelogenesis imperfecta, hypomaturation type, 2A6: A defect of enamel formation. The disorder involves both primary and secondary dentitions. [malacards.org]

Amelogenesis Imperfecta Type 1H

UniProtKB/Swiss-Prot : 73 Amelogenesis imperfecta 1H: A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that [malacards.org]

Definition A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored. [uniprot.org]

Type III: Hypocalcified In this type, a defect occurs in the initial stages of enamel formation. The enamel may have a normal thickness, but it’s too soft. [healthline.com]

Amelogenesis Imperfecta Type 2A4

UniProtKB/Swiss-Prot : 73 Amelogenesis imperfecta, hypomaturation type, 2A4: A defect of enamel formation. The disorder involves both primary and secondary dentitions. [malacards.org]

Definition A defect of enamel formation. The disorder involves both primary and secondary dentitions. [uniprot.org]

[…] of enamel formation. [genecards.org]

Amelogenesis Imperfecta Type 2A1

Definition A defect of enamel formation. The disorder involves both primary and secondary dentitions. [uniprot.org]

Type III: Hypocalcified In this type, a defect occurs in the initial stages of enamel formation. The enamel may have a normal thickness, but it’s too soft. [healthline.com]

formation. [aegisdentalnetwork.com]

Amelogenesis Imperfecta Type 4

UniProtKB/Swiss-Prot : 73 Amelogenesis imperfecta 4: An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. [malacards.org]

Description of the condition Amelogenesis imperfecta (AI) is a heterogeneous group of genetic disorders characterised by defects in enamel formation of the teeth in the absence [cochranelibrary.com]

Amelogenesis Imperfecta Type 1A

UniProtKB/Swiss-Prot : 73 Amelogenesis imperfecta 1A: A form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. [malacards.org]

Amelogenesis Imperfecta Type 3A

Definition An autosomal dominant hypomineralized form of amelogenesis imperfecta, a defect of enamel formation. [uniprot.org]

Type III: Hypocalcified In this type, a defect occurs in the initial stages of enamel formation. The enamel may have a normal thickness, but it’s too soft. [healthline.com]

Amelogenesis Imperfecta

Definition An autosomal recessive defect of dental enamel formation. Teeth show local hypoplastic and unmineralized enamel, and a yellow-brown discoloration. [uniprot.org]

enamel formation can be explained as defects occurring at the stages of enamel formation. [jisppd.com]

No previous study reported the occurrence of defects in enamel formation in patients with BS. [karger.com]

Amelogenesis imperfecta Type 2A3

Format Definition A defect of enamel formation. The disorder involves both primary and secondary dentitions. [uniprot.org]

An autosomal recessive defect of enamel formation (OMIM:204700), which affects the primary and secondary dentition. [medical-dictionary.thefreedictionary.com]

Jalili Syndrome

[…] of enamel formation, and CRD leading to loss of central vision and blindness. [iovs.arvojournals.org]

ProCite RefWorks Reference Manager © ARVO (1962-2015); The Authors (2016-present) × Supplements Abstract Purpose: : We ascertained six families with autosomal recessive AI, a defect [iovs.arvojournals.org]

Tricho-Dento-Osseous Syndrome

[…] of enamel formation associated with enlarged pulp chambers. [genecards.org]

AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Sequence similarities Belongs to the distal-less homeobox family. [abcam.com]

Disease description An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced. [uniprot.org]

Hypohidrotic Ectodermal Dysplasia

No previous study reported the occurrence of defects in enamel formation in patients with BS. [cyberleninka.org]

[…] in enamel formation. [indianjnephrol.org]

Dental defects: Abnormal morphogenesis or absence of teeth as well as enamel defects may occur. [13] Nail dystrophy: Abnormal nail plate formation may result in brittle, thin [emedicine.medscape.com]

X-Linked Amelogenesis Imperfecta Type 2

Type III: Hypocalcified In this type, a defect occurs in the initial stages of enamel formation. The enamel may have a normal thickness, but it’s too soft. [healthline.com]

The enamel may have formation disorders or even defects in its mineral and protein content1,2. [revodonto.bvsalud.org]

Abnormalities of Size and Form of Teeth

Enamel Defects  Matrix Formation  Mineralization  Maturation 4 5. [slideshare.net]

[…] state of tooth development or the calcification stage of enamel formation is defective (4). [hawaii.edu]

Enamel Defects Enamel Hypoplasia Occurs in form of pits, grooves or larger areas of missing enamel Diffuse Opacities Variation in the translucency of enamel. [slideshare.net]

Late Congenital Syphilis

enamel formation  Assume a peg / cork screw driver shape  Other incisors may also be effected 21. • Mulberry / Moon’s molars: First lower molars – commonly effected Under [slideshare.net]

Hutchinsons’ teeth  Seen at 6yrs / later  Permanent upper central incisors are shorter than the lateral incisors  Widely spaced  Have a notch in the bitting edge  Due to defective [slideshare.net]

Taurodontism Microdontia and Dens Invaginatus

Thinned and defective enamel & dentin formation Teeth are often carious, painful & usually extracted Reduced radiographic density produces ghost-like appearance and radiolucent [quizlet.com]

The hereditary defects of the formation of enamel also are divided along these lines: hypoplastic, hypocalcified, and hypomaturation. [indiandentalacademy.blogspot.com]

Hypoplasia: HEREDITARY Generalized defective enamel formation of primary and permanent dentition Hereditary disorder Four main types & 15 subtypes based on clinical, histological [quizlet.com]

Oculodentodigital Dysplasia

A group of hereditary conditions, termed the ectodermal dysplasias, may also be a cause for defective enamel formation, with missing teeth and hair problems being the usual [symptoma.com]

Amelogenesis imperfecta is another rare congenital condition in which defective formation of the tooth enamel results in the teeth being more sensitive to extremes of temperature [symptoma.com]

Familial Isolated Hypoparathyroidism

These findings include: dental hypoplasia, failure of eruption, defective enamel and root formation, and abraded carious teeth. 14. • Hypoparathyroidism occuring as a result [slideshare.net]

Acute Fluorine Poisoning

Dental fluorosis occurs due to defective formation of enamel. It is more severe in children with low calcium. [tandurust.com]

Autosomal Recessive Osteopetrosis Type 6

[…] dentition with incomplete enamel formation and/or caries paranasal sinuses: poorly pneumatized (ethmoid sinuses least severely affected) hypertelorism 2 calvaria: high-attenuation [radiopaedia.org]

Metaphyseal splaying may also be apparent 5. mandible: characteristic triangular opacity representing calcification within the secondary condylar cartilage ossification center 2 defective [radiopaedia.org]

X-Linked Mandibulofacial Dysostosis

Therefore, the disorder is characterized by abnormal pulp formation and defective mineralization of dentin, Enamel and cementum are unaffected, Both the primary and permanent [quizlet.com]

enamel formation that cannot be attributed to other systemic disorders, such as excessive fluoride intake, malnutrition or fever. [quizlet.com]

[…] rickets, Pegged or absent maxillary lateral incisors, Taurodontism Amelogenesis imperfecta is the name given to a group of hereditary disorders in which the common outcome is defective [quizlet.com]

Autosomal Recessive Osteopetrosis Type 5

Defective dentition with incomplete enamel formation and/or caries was encountered in all patients. [pubs.rsna.org]

[…] dentition with incomplete enamel formation and/or caries paranasal sinuses: poorly pneumatised (ethmoid sinuses least severely affected) hypertelorism 2 calvaria: high-attenuation [radiopaedia.org]

Autosomal Recessive Osteopetrosis Type 2

[…] dentition with incomplete enamel formation and/or cavities Paranasal sinuses: poorly pneumatised (ethmoid sinuses least severely affected) Hair-on-end appearance: areas of [boneandspine.com]

Dentinogenesis Imperfecta Type 1

It may be hereditary and may be associated with osteogenesis imperfecta. n 3. a hereditary condition associated with a defect in dentin formation; the enamel remains normal [medical-dictionary.thefreedictionary.com]

Type III: Hypocalcified In this type, a defect occurs in the initial stages of enamel formation. The enamel may have a normal thickness, but it’s too soft. [healthline.com]

[…] results secondarily in enamel that is also microscopically somewhat defective. [14] The exposed dentin, which is soft, undergoes quick attrition to such an extent that the [jomfp.in]

Junctional Epidermolysis Bullosa

defects in tooth enamel formation without other systemic manifestations. [ncbi.nlm.nih.gov]

The teeth, the changes have been described as deformities, birth defects and abnormal formation of enamel. [oatext.com]

Early dental intervention is important in JEB children (because of underlying enamel defects) so that permanent dentition is not lost as a result of severe caries formation [dermatologyadvisor.com]