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573 Possible Causes for Defective Myelination

  • Neonatal Adrenoleukodystrophy

    Most peroxisomal disorders cause severe neurological dysfunction due to CNS malformations (migration defects), myelin abnormalities, and neuronal degeneration.[] Adrenoleukodystrophy Related Terms Adrenal gland, ALD, brain defects, leukodystrophies, Lorenzo's oil, muscle defects, myelin sheath, very long chain fatty acids, VLCFA, X[]

  • Immunodeficiency Type 23

    defect, meningoencephalopathy, febrile seizure, prolonged VEP Low IQ, developmental delay, ataxia, CNS myelination defect, autism, febrile seizure Pulmonary Renal Hematologic[] (Continued) Neurologic Connective tissue Low IQ, dysarthria, ataxia, myoclonus, sensorineural hearing loss, CNS myelination defect, abnormal EEG, prolonged VEP Scoliosis,[] […] degenerative disc disease, dilated aortic root Bronchiectasis MPGN on hemodialysis Low IQ, dysarthria, ataxia, myoclonus, sensorineural hearing loss, CNS myelination defect[]

  • Vitamin B12 Deficiency

    VB12D causes perivascular degeneration and myelin degeneration.[] VB12D also results defects in the methylation processes resulting in neuropsychiatric symptoms. 2 In conclusion, VB12D can cause FTD-like dementia even in young individuals[]

  • Anemia

    Elevated MMA results in abnormal odd chain and branched chain fatty acids with subsequent abnormal myelination, possibly leading to defective nerve transmission.[] Brain MRI of infants with vitamin B-12 deficiency may show delayed myelination.[] SAM deficiency results in abnormal methylated phospholipids such as phosphatidylcholine, and it is linked to central myelin defects and abnormal neuronal conduction, which[]

  • Leukodystrophy

    The leukodystrophies are a group of disorders that are caused by genetic defects in how myelin produces or metabolizes these chemicals.[] Dysmyelination Hypo myelination is characterised by a defective structure and function of the myelin sheath in the brain and spinal cord.[] Abstract Genetic defects in myelin formation and maintenance cause leukodystrophies, a group of white matter diseases whose mechanistic underpinnings are poorly understood[]

  • Pelizaeus-Merzbacher Disease

    These findings suggested defective myelin synthesis as the etiology of Pelizaeus-Merzbacher disease; comprehensive classifications of the disease are expected to include both[] Pelizaeus Merzbacher Disease (PMD) is an X-linked developmental defect of myelination that causes childhood chronic spastic encephalopathy.[] Visit for more related articles at Journal of Neurological Disorders Abstract Pelizaeus-Merzbacher disease is a rare X-linked recessive disorder regarding the defective myelin[]

  • Neuropathy

    Charcot-Marie-Tooth disease comprises a vast array of defects in myelin integrity that causes progressive peripheral sensorimotor neuropathy.[]

  • Neurotic Disorder

    Prevention 21 22. • Loss of myelin in the CNS is considered to be a main pathogenic factor. • In animal models (carrying the underlying mutation for NPD), the expression[] . • DNA tests for Niemann-pick Type A & B  Identification of genetic defects in the DNA of many NPC patients  Carrier detection testing  Genetic testing and genetic counseling[]

  • Peripheral Neuropathy

    A kind of peripheral neuropathy is paresthesia . peripheral neuropathy Peripheral neuritis Neurology A functional defect of nerves outside the spinal cord, due to damage of[] […] peripheral nerves, axons or myelin sheath Clinical Numbness, weakness, burning pain–especially nocturnal, loss of reflexes; Sx depend on whether the 1º disorder affects sensory[]

  • Canavan Disease

    Consequently, CD results from defective myelin synthesis due to a deficiency in the supply of the NAA-derived acetate.[] Leukodystrophies are hereditary metabolic diseases in which the underlying biochemical abnormalities lead to defect of myelination.[] Canavan disease (CD) belongs to a group of conditions known as leukodystrophies, characterized by defects in myelin, commonly known as the "white matter" in the brain.[]

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