Degenerating Fibers: Causes & Reasons

Possible Causes for Degenerating Fibers

Autosomal Recessive Spastic Paraplegia Type 63

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Elastosis perforans serpiginosa

Histology shows degenerated elastic fibers that are eliminated through narrow channels formed in the acantotic hyperkeratotic epidermis. [jbpml.org.br]

[…] eosinophilic degenerated elastic fibers. 9. [histopathology-india.net]

(B) Nuclear debris and eosinophilic-degenerated elastic fibers present in multiple channel lumens (H&E, ×400). [ncbi.nlm.nih.gov]

Pseudoxanthoma Elasticum

Calcified degenerated elastic fibers are observed upon pathological analysis. [jle.com]

Positive stains Verhoeff's Van Gieson stain for elastic fibers shows marked degeneration of fibers with a short and curled appearance Von Kossa stain reveals calcium deposition [pathologyoutlines.com]

[…] shortened, tapered and degenerate ( Arch Dermatol 1965;92:373 ) Late-onset focal dermal elastosis: normal elastic fibers in the mid- and deep dermis, with no evidence of [pathologyoutlines.com]

Secondary Optic Atrophy

Here the pathology reveals chromatolysis and degeneration of ganglion cells and nerve fibers. [ijo.in]

Optic nerve fibers exhibit marked degeneration, with excessive proliferation of glial tissue. The architecture is lost, resulting in indistinct margins. [emedicine.medscape.com]

The degenerated axons do not possess this optical property, leading to the atrophic disc's pale appearance. [/i] Healthy optic disc. [thehealthscience.com]

Autosomal Recessive Spastic Paraplegia Type 27

Spinocerebellar fibers are involved to a lesser extent. Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [psychology.wikia.com]

Juvenile Colloid Milium

[…] collagen, serum proteins, or fibroblast secretions has been considered. [8] Recently literature has presented degenerated elastin fibers as the origin, but keratinocytes [idoj.in]

The origin of the colloid deposition in the dermis is not certain, but it is thought to be due to degeneration of elastic fibers in the adult form and due to degeneration [ncbi.nlm.nih.gov]

[…] of elastic fibers in the adult form and due to degeneration of UV-transformed keratinocytes in the juvenile form. [3] Colloid milium is characterized clinically by the development [advbiores.net]

Acquired Colloid Milium

The origin of the colloid deposition in the dermis is not certain, but it is thought to be due to degeneration of elastic fibers [5, 6] in the adult form and due to degeneration [emedicine.medscape.com]

The overlying epidermis is usually normal, but pseudoepitheliomatous hyperplasia can occur.5,10 In long-standing disease, ochronotic fibers may degenerate to form colloid [redalyc.org]

In long-standing disease, ochronotic fibers may degenerate to form colloid milium. [scielo.br]

Vitreous Degeneration

degeneration. descending degeneration Nerve fiber degeneration progressing toward the periphery from the original lesion. fatty degeneration Deposit of abnormal amounts of [medical-dictionary.thefreedictionary.com]

The liver, spleen, and kidneys are usually involved, but any tissue may be infiltrated. ascending degeneration Nerve fiber degeneration progressing to the center from the [medical-dictionary.thefreedictionary.com]

The disease produces symptoms similar to those found in Parkinson's disease but does not respond to parkinsonian medications. cystic degeneration Cyst formation accompanying [medical-dictionary.thefreedictionary.com]

Pseudoxanthoma Elasticum-Like Papillary Dermal Elastolysis

Clumping and fragmentation of elastic fibers, loss of elaunin and oxylatan fibers in the papillary dermis of lesional skin, and granular and fibrillar degeneration of elastic [escholarship.org]

fibers in perilesional areas may also be seen [4]. [escholarship.org]

Linear Focal Elastosis

Electron microscopy shows irregular fragmented and degenerating elastic fibers (original magnification ×9000). fibers characterized by thin, wavy, elongated as well as fragmented [jamanetwork.com]

Currently, degeneration and regeneration of elastic fiber is thought to be a possible pathomechanism.[4] Clinically, these lesions are characterized by skin coloured to yellowish [e-ijd.org]

Semithin (1-μm) section demonstrated increased amount of thin and fragmented elastic fibers (toluidine blue stain, ×240). Figure 2. [jamanetwork.com]

Conjunctivochalasis

[…] of elastic fibers and chronic inflammation.11 Elastic fiber degeneration is seen in pingueculae, pterygia and photoaged skin, which suggests that conjunctivochalasis is induced [reviewofophthalmology.com]

[…] association with inflammatory cytokines.9 Histopathologic studies are conflicting: Some have shown normal conjunctiva on microscopic evaluation10 and others have demonstrated degeneration [reviewofophthalmology.com]

Cutis Rhomboidalis Nuchae

There is the occurrence of elastic and collagen fibers degeneration found in the dermis caused by ultraviolet radiation [1]. [pubmed.ncbi.nlm.nih.gov]

10 The deposition of amorphous material associated with elastic fiber degeneration has been reported, as well as preserved collagen fibers and bundle disorganization.11 Considering [anaisdedermatologia.org.br]

The deposition of amorphous material associated with elastic fiber degeneration has been reported, as well as preserved collagen fibers and bundle disorganization.1111 Lavker [scielo.br]

Acquired Pseudoxanthoma elasticum

Introduction Hereditary pseudoxanthoma elasticum (PXE) is a disorder that results from degeneration and calcification of elastic fibers in cutaneous, ocular, and cardiovascular [ispub.com]

It is suggested that repeated traumas of pregnancy, obesity, or abdominal surgery promote localized degeneration of elastic fibers. [advances-in-medicine.net]

It is characterized by elastic fiber degeneration and calcifications, seen in the midlower dermal areas. [omicsonline.org]

Limb-Girdle Muscular Dystrophy Type 2L

Muscle biopsy reveal myopathic or dystrophic changes with variation in fiber size, central nuclei, fiber splitting, degeneration of muscle fibers, and an increase in connective [egl-eurofins.com]

The disease causes muscle degeneration, progressive weakness, fiber death, fiber branching and splitting, phagocytosis (in which muscle fiber material is broken down and destroyed [tellmegen.com]

[…] of the fibers of the affected nerve. [medical-dictionary.thefreedictionary.com]

Limb-Girdle Muscular Dystrophy Type 2G

[…] and myofiber splitting, focal intrasarcoplasmic glycogen deposits, many degenerating fibers, very small atrophic fibers with or without degeneration signs, and autophagic [ncbi.nlm.nih.gov]

[…] total deficiency (Figure 2 C), consistent with telethoninopathy (Limb Girdle Muscular Dystrophy type 2G).Transmission electron microscopy demonstrated endomysial fibrosis, fiber [bmcclinpathol.biomedcentral.com]

Muscle fiber degeneration in distal myopathy with rimmed vacuole formation. [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 44

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

The longest fibers, innervating the lower extremities, are the most affected. [psychology.wikia.com]

X-Linked Spastic Paraplegia Type 34

Spinocerebellar fibers are involved to a lesser extent. Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [psychology.wikia.com]

Epithelioid Neurofibroma

Antoni A areas Contains lipid Has characteristic Luse bodies (collagen fibers with abnormally long spacing exceeding 100 nm between electron dense bands) Electron microscopy [pathologyoutlines.com]

Tumor cells have ill defined cytoplasm, dense chromatin May have degenerative nuclear atypia, cystic degeneration and hemorrhage (ancient change) Blood vessels may have thickened [pathologyoutlines.com]

Nuclear palisading around fibrillary process (Verocay bodies) is often seen in cellular areas Cells are narrow, elongated and wavy with tapered ends interspersed with collagen fibers [pathologyoutlines.com]

Autosomal Recessive Spastic Paraplegia Type 48

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Cystic Medial Necrosis of the Aorta

Erdheim cystic medial necrosis changes in the medial layer of the aorta, consisting of degeneration and necrosis of elastic and muscle fibers, mucoid infiltration, and cyst [medicine.academic.ru]

This entity consists of degeneration of collagen and elastin fibers in the tunica media of the aorta as well as cell loss in the medial layer. [usmleforum.com]

[…] and necrosis of elastic and muscle fibers, mucoid infiltration, and cyst formation, often resulting in dissecting aneurysm; called also Erdheim disease and medionecrosis [medicine.academic.ru]

Muscular Dystrophy-Dystroglycanopathy Type A13

degeneration (necrosis) and regeneration. [ncbi.nlm.nih.gov]

[…] genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber [ncbi.nlm.nih.gov]

X-linked Spastic Paraplegia Type 16

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 57

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 61

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 25

Spinocerebellar fibers are involved to a lesser extent. Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

[…] of the long corticospinal fibers that reach from the motor cortex to the spinal cord. [epilepsygenetics.net]

Autosomal Recessive Spastic Paraplegia Type 46

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]

[…] gracilis fibers that is maximal in the cervicomedullary region; and a degree of demyelination that is considered to be secondary to axon degeneration. [mhmedical.com]

Muscular Dystrophy-Dystroglycanopathy Type A5

degeneration (necrosis) and regeneration. [ncbi.nlm.nih.gov]

Subacute Combined Degeneration of Spinal Cord

Called also Lichtheim's or Putnam-Dana syndrome. wallerian degeneration fatty degeneration of a nerve fiber that has been severed from its nutritive source. subacute combined [medical-dictionary.thefreedictionary.com]

In subacute combined degeneration, the myelin is damaged, causing sensory and motor nerve fibers from the spinal cord to degenerate. [merckmanuals.com]

degeneration of spinal cord Degeneration of the posterior and lateral columns of the spinal column. [medical-dictionary.thefreedictionary.com]

Charcot-Marie-Tooth Disease Type 2B1

/regeneration Decreased motor nerve conduction velocity Decreased number of peripheral myelinated nerve fibers Distal sensory impairment Onion bulb formation Peripheral axonal [ncbi.nlm.nih.gov]

/regeneration Decreased motor nerve conduction velocity Decreased number of peripheral myelinated nerve fibers Distal sensory impairment Hyporeflexia Onion bulb formation [ncbi.nlm.nih.gov]

[…] amyotrophy Distal muscle weakness Foot dorsiflexor weakness Kyphoscoliosis Proximal muscle weakness Upper limb muscle weakness Abnormality of the nervous system Areflexia Axonal degeneration [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 35

Although some degeneration of the fibers supplying the arms commonly takes place, most people with HSP do not have symptoms in the hands or arms. [emedicine.medscape.com]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [centogene.com]