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39 Possible Causes for Degeneration of Epidermal Basal Cells

  • Vasculitis

    There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] Keratinisation Keratinisation is the process by which epidermal cells ( keratinocytes ) undergo maturation and differentiation, as the cell migrates from the basal layer to[dermnetnz.org] Epidermolytic dyskeratosis Epidermolytic dyskeratosis is abnormal epidermal maturation characterised by vacuolar degeneration of the stratum granulosum and stratum spinulosum[dermnetnz.org]

  • Lupus Erythematosus

    […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] and fatigability, joint pains or arthritis resembling rheumatoid arthritis, diffuse erythematous skin lesions on the face, neck, or upper extremities, with liquefaction degeneration[medical-dictionary.thefreedictionary.com]

  • Systemic Lupus Erythematosus

    […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] and fatigability, joint pains or arthritis resembling rheumatoid arthritis, diffuse erythematous skin lesions on the face, neck, or upper extremities, with liquefaction degeneration[medical-dictionary.thefreedictionary.com]

  • Erythema Multiforme

    Histologic Features: Basal cell hydropic degeneration, which may be severe enough to result in the formation of subepidermal clefts or vesicles Apoptosis of keratinocytes,[dermpedia.org] The former group displayed inflammatory changes such as spongiosis and exocytosis, and focal liquefactive degeneration of the basal cell zone of the epidermis; while the latter[clinicaladvisor.com] […] of the basal layer, subdermal blister formation, and epidermal necrosis of keratinocytes that increases with older lesions.[jiaomr.in]

  • Bazex Syndrome

    […] and never of mesodermal origin, possible histopathological changes including the presence of necrotic foci, scattered vacuolar degeneration of basal cells, cytoplasmic eosinophilia[bmccancer.biomedcentral.com] […] where the pathomechanism of Acrotkeratosis paraneoplastica may be related to an immunological reaction as indicated by multiple factors: association with tumours always of epidermal[bmccancer.biomedcentral.com]

  • Lichen Sclerosus

    […] with hydropic degeneration of basal cell, flattening of rete ridges, pronounced edema, and homogenization of collagen in upper dermis with lymphocytic infiltrate in mid-dermis[ncbi.nlm.nih.gov] Characteristic histopathological changes show lichenoid infiltrate in the dermal-epidermal junction compact hyperkeratosis with follicular plugging, atrophy of stratum malpighii[ncbi.nlm.nih.gov]

  • Rare Cutaneous Lichen Planus

    There is a T-cell infiltrate at the dermo-epidermal junction, with vacuolar or liquefactive degeneration of the basal cells of the epidermis.[news-medical.net]

  • Epidermolysis Bullosa Simplex

    epidermal cells.[ncbi.nlm.nih.gov] […] layer caused by degeneration of individual epidermal cells Dystrophic EB: pretibial lesion Electron microscopy description Electron microscopy images Images hosted on other[pathologyoutlines.com] Abstract Epidermolysis bullosa simplex (EBS) is a group of autosomal dominant skin diseases characterized by blistering, due to mechanical stress-induced degeneration of basal[ncbi.nlm.nih.gov]

  • Discoid Lupus Erythematosus

    A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov] […] membrane (best demonstrated by periodic acid-Schiff staining) and vacuolar degeneration of the basal cells along with perivascular and peri-appendageal inflammatory cell[doi.org] Histology may be required to confirm the diagnosis; it is that of a lichenoid tissue reaction with changes at the dermo-epidermal junction that include thickening of the basement[doi.org]

  • Zinc-Responsive Necrolytic Acral Erythema

    However, the focal nature of epidermal dyskeratosis and pallor, along with basal cell vacuolar degeneration can be useful in distinguishing NAE from other clinical mimickers[dermatologyadvisor.com]

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