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13 Possible Causes for Degeneration of Epidermal Basal Cells, Elevated Sedimentation Rate

  • Vasculitis

    Their results will generally show signs of inflammation in the body, such as increased erythrocyte sedimentation rate (ESR), elevated C-reactive protein (CRP), anemia, increased[en.wikipedia.org] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] The univariate analysis demonstrated a significant association between systemic vasculitic involvement and elevated erythrocyte sedimentation rate (cRR, 4.15), leukocytosis[jamanetwork.com]

  • Systemic Lupus Erythematosus

    Initial labs showed pancytopenia, bandemia, proteinuria, elevated erythrocyte sedimentation rate, and elevated d-dimer.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] Investigations revealed anaemia, leucopenia and elevated erythrocyte sedimentation rate.[ncbi.nlm.nih.gov]

  • Erythema Multiforme

    Laboratory Findings Laboratory findings are non-specific and can include an elevated erythrocyte sedimentation rate ( ESR ), elevated white blood cell count ( WBC ), and elevated[wikidoc.org] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com] Laboratory studies showed an elevated erythrocyte sedimentation rate of 62 mm/h and an elevated C-reactive protein level of 59 mg/L.[consultant360.com]

  • Lupus Erythematosus

    The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.[fpnotebook.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of le cells in the blood or bone marrow.[icd10data.com]

  • Discoid Lupus Erythematosus

    rate will be elevated Rheumatoid factor- may be positive Urinalysis – Urine test may show involvement of kidneys.[steadyhealth.com] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov] […] membrane (best demonstrated by periodic acid-Schiff staining) and vacuolar degeneration of the basal cells along with perivascular and peri-appendageal inflammatory cell[doi.org]

  • Chilblain Lupus Erythematosus

    A faster than normal rate may indicate a systemic disease, such as lupus. The sedimentation rate isn’t specific for any one disease.[healthjade.com] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com] These may include anti-dsDNA, anti-Smith, CBC with differential, creatinine, albumin, total protein, erythrocyte sedimentation rate, and complements (C3, C4).[dermatologyadvisor.com]

  • Tuberculid

    Serum immunoglobulins (IgG, A and M) were moderately elevated. Erythrocyte sedimentation rate and C-reactive protein level were normal. Syphilis serology was negative.[magonlinelibrary.com] The earlobe biopsy showed epidermal hyperkeratosis and parakeratosis, liquefaction degeneration of the basal cells, and follicular keratotic plugging, and the blood vessels[cmj.yiigle.com] Focal lymphocytic infiltrate and focal vacuolar degeneration of the basal cell layer were seen at the dermal-epidermal junction.[cyberleninka.org]

  • Chronic Lichenoid Pityriasis

    sedimentation rate. 6 Unfortunately, even though electron microscopy shows some viral changes and possible viral particles, antibody and polymerase chain reaction tests for[aafp.org] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[e-ijd.org] Findings of laboratory studies revealed an elevated erythrocyte sedimentation rate, a high white blood cell count, and a mild increase in liver enzymes.[karibu.pro]

  • ALK+ Histiocytosis

    Laboratory abnormalities are nonspecific with elevated erythrocyte sedimentation rate and leukocytosis, high ferritin, hypergammaglobulinemia, and autoimmune hemolytic anemia[ncbi.nlm.nih.gov] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[plasticsurgerykey.com]

  • Erythema Annulare Centrifugum

    FBC, erythrocyte sedimentation rate (ESR) and CXR may be useful in excluding malignancy. Lyme antibody titre to exclude erythema migrans may be appropriate.[patient.info] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in] Hyperbilirubinaemia and elevated transaminase levels may be found.[patient.info]

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