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37 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Eruptions

  • Erythema Multiforme

    We report a case of an erythema multiforme drug eruption associated with erythrodermic psoriasis induced by SOF and DCV.[ncbi.nlm.nih.gov] […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[aaaai.org] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com]

  • Pityriasis Circinata

    Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis and papular-purpuric gloves[doi.org] In the drug induced form there is no herald patch, individual lesions tend to be violet-red in colour, pruritus is more severe, and eosinophilia may be present.[doi.org] Besides, histology shows epidermal atrophy and basal layer degeneration.[wjgnet.com]

  • Systemic Lupus Erythematosus

    We postulate that this eruption was related to SLE and anticardiolipin antibodies.[ncbi.nlm.nih.gov] In rare cases, pleural eosinophilia is associated with connective tissue disease.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Erythema Annulare Centrifugum

    EAC with cancers or paraneoplastic erythema annulare centrifugum eruptions (PEACE), is more likely to be associated with lymphoproliferative malignancies such as lymphomas[ncbi.nlm.nih.gov] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in] A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[ncbi.nlm.nih.gov]

  • Actinic Lichen Planus

    , polymorphous light eruption, and erythema dyschronicum perstans. 5 The clinician also must exclude the possibility of a drug-induced photosensitive lichenoid eruption by[mdedge.com] Carcinoma Bowen's Disease Chronic Actinic Skin Damage Cornu Cutaneum Discoid Lupus Erythematosus (DLE) Disseminated Superficial Actinic Porokeratosis Facial Granuloma with Eosinophilia[skincancer.dermis.net] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com]

  • Photosensitivity Disorder

    Polymorphous light eruption This eruption is a reaction to sunlight (primarily UVA light) that is not fully understood.[merckmanuals.com] The syndrome typically includes skin rash and fever, often with hepatitis, arthralgias, lymphadenopathy, or haematological disorders (mainly eosinophilia and atypical lymphocytosis[pmj.bmj.com] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[ncbi.nlm.nih.gov]

  • Bullous Lichen Planus

    There were significant differences between familial and non-familial BLP in age of onset, duration of disease and extension of eruption (P[ncbi.nlm.nih.gov] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[jemds.com] Histopathology showed a subepidermal blistering disease with tissue eosinophilia consistent with lichen planus pemphigoides (LPP)(Figure 2); direct immunofluorescence was[mdedge.com]

  • Vasculitis

    Drug eruption was been confirmed by means of a challenge test, together with histopathological and clinical findings.[ncbi.nlm.nih.gov] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Chronic Lichenoid Pityriasis

    […] diseases characterized by the formation of fine, branny scales. acute lichenoid pityriasis an acute or subacute, sometimes relapsing, widespread macular, papular, or vesicular eruption[medical-dictionary.thefreedictionary.com] Acquired digital fibrokeratoma Angiolymphoid hyperplasia with eosinophilia vs. Angiosarcoma Angiolymphoid hyperplasia with eosinophilia vs.[derm101.com] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[e-ijd.org]

  • Bazex Syndrome

    Bazex syndrome, a rare paraneoplastic syndrome characterized by psoriasiform eruptions, palmoplantar keratosis, and symmetric onychodystrophy, is most prevalent with squamous[ncbi.nlm.nih.gov] […] and never of mesodermal origin, possible histopathological changes including the presence of necrotic foci, scattered vacuolar degeneration of basal cells, cytoplasmic eosinophilia[bmccancer.biomedcentral.com] The mild eosinophilia subsided and levels of SCC antigen, IgE, and soluble interleukin-2 receptor were reduced.[obesity.thehealthwell.info]

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