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31 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Leukemia

  • Systemic Lupus Erythematosus

    In rare cases, pleural eosinophilia is associated with connective tissue disease.[ncbi.nlm.nih.gov] The JAK2 V617, Myeloproliferative leukemia (MPL) and calreticulin mutations were negative.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Erythema Multiforme

    […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[aaaai.org] In this case of acute promyelocytic leukemia, EM diagnosed during the induction phase was mistakenly attributed to vancomycin used to treat febrile neutropenia during that[ncbi.nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com]

  • Graft-versus-Host-Disease

    But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[cancertherapyadvisor.com] We describe the case of a patient with Philadelphia-positive acute lymphoblastic leukemia treated with dasatinib plus steroids as first-line therapy, who achieved a major[ncbi.nlm.nih.gov] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov]

  • Photosensitivity Disorder

    The syndrome typically includes skin rash and fever, often with hepatitis, arthralgias, lymphadenopathy, or haematological disorders (mainly eosinophilia and atypical lymphocytosis[pmj.bmj.com] T66 Radiation sickness, unspecified 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes specified adverse effects of radiation, such as: burns ( T20 - T31 ) leukemia[icd10data.com] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[ncbi.nlm.nih.gov]

  • Vasculitis

    All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov] Blood cell cancers – leukemia and lymphoma can cause vasculitis. Exposure to chemicals/drugs.[brighamandwomens.org] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Erythema Annulare Centrifugum

    A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[ncbi.nlm.nih.gov] […] with cancers or paraneoplastic erythema annulare centrifugum eruptions (PEACE), is more likely to be associated with lymphoproliferative malignancies such as lymphomas and leukemias[ncbi.nlm.nih.gov] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

  • ALK+ Histiocytosis

    […] disease Peripheral or abdominal lymphadenopathy, extranodal infiltrates, bone marrow involvement, B symptoms (especially high fever) Anemia, pancytopenia, high LDH, occasional eosinophilia[pathologyoutlines.com] Updated with the most current WHO classifications of hematologic disease, including lymphoma and leukemia and peripheral T-cell lymphomas.[books.google.es] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[plasticsurgerykey.com]

  • Pityriasis Circinata

    The remaining chapters concentrate on major inflammatory skin diseases and lymphoproliferative disorders, including chronic lymphocytic leukemia, lupus, adult T cell leukemia[books.google.com] Besides, histology shows epidermal atrophy and basal layer degeneration.[wjgnet.com] In the drug induced form there is no herald patch, individual lesions tend to be violet-red in colour, pruritus is more severe, and eosinophilia may be present.[doi.org]

  • Chilblain Lupus Erythematosus

    Blood tests: FBC may show raised white count/eosinophilia or lymphopenia. Anaemia may be seen. ESR is often raised ( 65% of cases).[patient.info] Drug-induced pernio: Sulindac induced cases have been reported Laboratory Studies CBC count and sedimentation rate should be obtained to rule out associated leukemia.[dermaamin.com] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com]

  • Erythema Marginatum

    Another patient experienced exacerbations of EAC premenstrually as a type of autoimmune progesterone dermatitis. [27] Hypereosinophilic syndrome: A patient with 31% eosinophilia[emedicine.medscape.com] 470 Acute Myeloid Leukemia 473 Hodgkins Disease 475 NonHodgkins Lymphoma 476 Malignant Bone Tumors 477 Malignant Brain Tumors 479 Wilms Tumor 481 Neuroblastoma 482 Retinoblastoma[books.google.com] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

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