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10 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Leukocytes Decreased

  • Systemic Lupus Erythematosus

    In rare cases, pleural eosinophilia is associated with connective tissue disease.[ncbi.nlm.nih.gov] Decreased IL-12 production by polymorphonuclear leukocytes in patients with active systemic lupus erythematosus. Immunol Invest 2002;31:177–89 106.[journals.lww.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Graft-versus-Host-Disease

    But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[oncologynurseadvisor.com] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov] Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children . Transplantation 2004; 77 : 1096–1100. 32.[nature.com]

  • Vasculitis

    All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov] Some of the patients may show a biopsy with leukocytoclastic vasculitis some only leukocytic infiltration without vasculitis [ 49 ].[intechopen.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Erythema Annulare Centrifugum

    A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[ncbi.nlm.nih.gov] leukocytes.[jamanetwork.com] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

  • Human Herpesvirus 3

    The reactivation of herpesviruses, including HHV-6 and EBV, is linked with a potentially serious drug eruption known as DRESS (drug reaction with eosinophilia and systemic[emedicine.medscape.com] Results from a skin biopsy specimen demonstrated focal hydropic and vacuolar degeneration of epidermal basal cells, with marked exocytosis of atypical lymphoid cells into[jamanetwork.com] […] tissues, cells, and fluid in association with the following conditions: Lymphoma Lymphadenopathy Drug-induced hypersensitivity syndrome (DIHS), [10] or drug reaction with eosinophilia[emedicine.medscape.com]

  • Lupus Erythematosus

    Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[doi.org] Decreased IL-12 production by polymorphonuclear leukocytes in patients with active systemic lupus erythematosus. Immunol Invest 2002;31:177–89 106.[journals.lww.com] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Human Herpesvirus 6

    Peripheral smear did not demonstrate eosinophilia but showed toxic granulation with atypical lymphocytes.[ncbi.nlm.nih.gov] Furthermore, it has been published that the treatment leads to a significant decrease in serum IgM and IgG levels in patients with MS; these findings might support the hypothesis[doi.org] Results from a skin biopsy specimen demonstrated focal hydropic and vacuolar degeneration of epidermal basal cells, with marked exocytosis of atypical lymphoid cells into[jamanetwork.com]

  • Etretinate

    Mianserin agranulocytosis followed by oxitriptan eosinophilia. Nervenarzt. 1992 ;63: 303 – 307. Google Scholar Medline 90. Anonymous. Posicor.[doi.org] It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Use 0.1% cream.[emedicine.medscape.com] […] and epidermal-dermal interphase activity with liquefaction degeneration of basal cells and a band-like cell infiltration consisting of lymphoid cells and histiocytes.[ncbi.nlm.nih.gov]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    Peripheral blood eosinophilia of at lease 1500 eos/uL a. Longer than 6 mo OR b. Less than 6 mo with evidence of organ damage 2.[cram.com] Factors that warranted consideration when planning her dental treatment included diet, blood glucose levels, reduced leukocyte function, and decreased integrity of the blood[zdoc.site] Vacuolated cells and others showing filamentous degeneration (‘dyskeratotic’ cells) are often present.[plasticsurgerykey.com]

  • Rabson Mendenhall Syndrome

    Oncocytic cells contain abundant large mitochondria that impart cytoplasmic granularity and eosinophilia which could be mistaken for an acidophilic growth hormone adenoma.[jnnp.bmj.com] […] insulin binding to circulating leukocytes ( 4 ) and is currently used for both female and male patients with severe inherited insulin resistance and acanthosis nigricans[academic.oup.com] H&E staining revealed mild epidermal hyperplasia with hyperkeratosis, increased pigment in local basal cells, hyperplasia and degeneration of collagen fibers, and minor infiltration[spandidos-publications.com]

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