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17 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Splenomegaly

  • Systemic Lupus Erythematosus

    […] relapsing illness, with a variety of different presentations. [ 5 , 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[] In rare cases, pleural eosinophilia is associated with connective tissue disease.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[]

  • Lupus Erythematosus

    […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[] Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[]

  • ALK+ Histiocytosis

    Hypersplenism is a cytopenia resulting from blood pooling in the spleen and is almost always associated with splenomegaly.[] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[] […] disease Peripheral or abdominal lymphadenopathy, extranodal infiltrates, bone marrow involvement, B symptoms (especially high fever) Anemia, pancytopenia, high LDH, occasional eosinophilia[]

  • Vasculitis

    Gabriele Hahn, Pädiatrische Radiologie, Universitätsklinikum Carl Gustav Carus, TU Dresden); (B) Necrotizing skin vasculitis on legs and feet; (C) Splenomegaly, spleen with[] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[]

  • Graft-versus-Host-Disease

    The clinical findings mainly include high fever, cytopenia, splenomegaly, phagocytosis, and proliferation of histiocytes in lymphoreticular tissue.[] But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[]

  • Erythema Annulare Centrifugum

    Abdomen: Appendicitis, [6] lymphoma (with associated splenomegaly), and liver disease [3] (eg, cholelithiasis, hepatitis), and pregnancy have been reported with EAC.[] A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[]

  • Photosensitivity Disorder

    Thirty-three months later, an increase in his white cell count (73 10 9 /L; 79% neutrophils) was associated with splenomegaly and splenic infarction that required emergency[] The syndrome typically includes skin rash and fever, often with hepatitis, arthralgias, lymphadenopathy, or haematological disorders (mainly eosinophilia and atypical lymphocytosis[] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[]

  • Gangrenous Balanitis

    Sonography-Abdomen: splenomegaly. Sonography-Lymph nodes: multiple enlarged lymph nodes, regionally and peripherally located (axillary).[] Affected patients have severe pruritus and peripheral eosinophilia.[] […] junction where there is basal cell liquefactive degeneration and a variable number of cytoid (Civatte) bodies.[]

  • Chilblain Lupus Erythematosus

    Abdomen Check for hepatomegaly and splenomegaly.[] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[] […] dermatitis often associated with effacement of the retia, morphology reminiscent of linear IgA disease Histiocytes engulfing nuclear debris of disintegrating neutrophils Tissue eosinophilia[]

  • Chronic Lichenoid Pityriasis

    Limited lymphadenopathy, splenomegaly and hepatomegaly are sometimes detected. When present, hepatitis is usually anicteric.[] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[] Acquired digital fibrokeratoma Angiolymphoid hyperplasia with eosinophilia vs. Angiosarcoma Angiolymphoid hyperplasia with eosinophilia vs.[]

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