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24 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[] In rare cases, pleural eosinophilia is associated with connective tissue disease.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[]

  • Graft-versus-Host-Disease

    […] in patients without thrombocytopenia and 26% in those with thrombocytopenia because of increased infectious mortality in the latter group.[] But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[] Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[]

  • Erythema Multiforme

    […] with features of oral ulcers, arthritis, immunological (positive anti-nuclear antibody in speckled pattern, anti-ds DNA, anti-Sm), hematological (anemia, lymphopenia and thrombocytopenia[] […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[]

  • ALK+ Histiocytosis

    Anemia, thrombocytopenia, and hepatosplenomegaly are the hallmarks of ALK H.[] […] disease Peripheral or abdominal lymphadenopathy, extranodal infiltrates, bone marrow involvement, B symptoms (especially high fever) Anemia, pancytopenia, high LDH, occasional eosinophilia[] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[]

  • Vasculitis

    ‘Other side effects include hepatitis, vasculitis, and thrombocytopenia.’[] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[]

  • Chilblain Lupus Erythematosus

    […] psychosis ; both in the absence of offending drugs or known metabolic derangements Laboratory tests Hematologic disorders Autoimmune hemolytic anemia with reticulocytes OR Thrombocytopenia[] Blood tests: FBC may show raised white count/eosinophilia or lymphopenia. Anaemia may be seen. ESR is often raised ( 65% of cases).[] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[]

  • Bazex Syndrome

    […] thrombosis is associated with mucinous adenocarcinoma, myeloproliferative disorders, and metastatic cancers. [36] Erythromelalgia is seen in polycythemia vera and essential thrombocytopenia[] The mild eosinophilia subsided and levels of SCC antigen, IgE, and soluble interleukin-2 receptor were reduced.[] […] and never of mesodermal origin, possible histopathological changes including the presence of necrotic foci, scattered vacuolar degeneration of basal cells, cytoplasmic eosinophilia[]

  • Gangrenous Balanitis

    In one study, up to 42% of patients with sickle cell disease reported at least one episode of priapism. 4 Other causes include thalassemia, leukemia, polycythemia, and thrombocytopenia[] Affected patients have severe pruritus and peripheral eosinophilia.[] […] junction where there is basal cell liquefactive degeneration and a variable number of cytoid (Civatte) bodies.[]

  • Bullous Lichen Planus

    […] and peripheral radiating white lines *Oral lesions may occur in SLE and CCLE Systemic Lupus Erythematosus - Laboratory Abnormalities Hematologic changes: Anemia Leukopenia Thrombocytopenia[] Histopathology showed a subepidermal blistering disease with tissue eosinophilia consistent with lichen planus pemphigoides (LPP)(Figure 2); direct immunofluorescence was[] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[]

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