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24 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] In rare cases, pleural eosinophilia is associated with connective tissue disease.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Graft-versus-Host-Disease

    […] in patients without thrombocytopenia and 26% in those with thrombocytopenia because of increased infectious mortality in the latter group.[doi.org] But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[cancertherapyadvisor.com] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[doi.org] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Erythema Multiforme

    […] with features of oral ulcers, arthritis, immunological (positive anti-nuclear antibody in speckled pattern, anti-ds DNA, anti-Sm), hematological (anemia, lymphopenia and thrombocytopenia[e-ijd.org] […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[aaaai.org] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com]

  • ALK+ Histiocytosis

    Anemia, thrombocytopenia, and hepatosplenomegaly are the hallmarks of ALK H.[symptoma.com] […] disease Peripheral or abdominal lymphadenopathy, extranodal infiltrates, bone marrow involvement, B symptoms (especially high fever) Anemia, pancytopenia, high LDH, occasional eosinophilia[pathologyoutlines.com] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[plasticsurgerykey.com]

  • Vasculitis

    ‘Other side effects include hepatitis, vasculitis, and thrombocytopenia.’[en.oxforddictionaries.com] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Chilblain Lupus Erythematosus

    […] psychosis ; both in the absence of offending drugs or known metabolic derangements Laboratory tests Hematologic disorders Autoimmune hemolytic anemia with reticulocytes OR Thrombocytopenia[amboss.com] Blood tests: FBC may show raised white count/eosinophilia or lymphopenia. Anaemia may be seen. ESR is often raised ( 65% of cases).[patient.info] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com]

  • Bazex Syndrome

    […] thrombosis is associated with mucinous adenocarcinoma, myeloproliferative disorders, and metastatic cancers. [36] Erythromelalgia is seen in polycythemia vera and essential thrombocytopenia[ijmpo.org] The mild eosinophilia subsided and levels of SCC antigen, IgE, and soluble interleukin-2 receptor were reduced.[obesity.thehealthwell.info] […] and never of mesodermal origin, possible histopathological changes including the presence of necrotic foci, scattered vacuolar degeneration of basal cells, cytoplasmic eosinophilia[bmccancer.biomedcentral.com]

  • Gangrenous Balanitis

    In one study, up to 42% of patients with sickle cell disease reported at least one episode of priapism. 4 Other causes include thalassemia, leukemia, polycythemia, and thrombocytopenia[ahcmedia.com] Affected patients have severe pruritus and peripheral eosinophilia.[clevelandclinicmeded.com] […] junction where there is basal cell liquefactive degeneration and a variable number of cytoid (Civatte) bodies.[abdominalkey.com]

  • Bullous Lichen Planus

    […] and peripheral radiating white lines *Oral lesions may occur in SLE and CCLE Systemic Lupus Erythematosus - Laboratory Abnormalities Hematologic changes: Anemia Leukopenia Thrombocytopenia[quizlet.com] Histopathology showed a subepidermal blistering disease with tissue eosinophilia consistent with lichen planus pemphigoides (LPP)(Figure 2); direct immunofluorescence was[mdedge.com] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[jemds.com]

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