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30 Possible Causes for Degeneration of Epidermal Basal Cells, Eosinophilia, Weight Loss

  • Systemic Lupus Erythematosus

    loss.[] In rare cases, pleural eosinophilia is associated with connective tissue disease.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[]

  • Vasculitis

    weight loss over 2 months.[] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[]

  • Graft-versus-Host-Disease

    Weight loss.[] But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[]

  • Erythema Multiforme

    The patient denied any history of fever, rigors, sweating, cough, sputum production, diarrhea, loss of weight.[] […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[]

  • Lupus Erythematosus

    Many patients with active lupus feel poorly in general and complain of fever, weight loss and tiredness.[] Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[]

  • Bazex Syndrome

    He was also discovered to have an enlarged mass on the left side of his neck and weight loss of 4 kg without other B symptoms (i.e., fever, night sweats, and weight loss).[] The mild eosinophilia subsided and levels of SCC antigen, IgE, and soluble interleukin-2 receptor were reduced.[] […] and never of mesodermal origin, possible histopathological changes including the presence of necrotic foci, scattered vacuolar degeneration of basal cells, cytoplasmic eosinophilia[]

  • Bullous Lichen Planus

    There was no history of weight loss, fever or exacerbation of the eruption with sun exposure.[] Histopathology showed a subepidermal blistering disease with tissue eosinophilia consistent with lichen planus pemphigoides (LPP)(Figure 2); direct immunofluorescence was[] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[]

  • Erythema Annulare Centrifugum

    Should weight gain become a problem later on, institute more systematic, supervised efforts (for example, weight loss programs and formal exercise classes).[] A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[]

  • Chilblain Lupus Erythematosus

    Typically, the patient seeks medical help for relief of fever, weight loss, joint pain, the characteristic butterfly rash, pleural effusion and pleuritic pain, and nephritis[] Blood tests: FBC may show raised white count/eosinophilia or lymphopenia. Anaemia may be seen. ESR is often raised ( 65% of cases).[] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[]

  • ALK+ Histiocytosis

    Not all people with hereditary neuroblastoma will have all the symptoms listed below: Flu-like symptoms (fever, feeling tired/fatigue, pain, loss of appetite, weight loss[] […] disease Peripheral or abdominal lymphadenopathy, extranodal infiltrates, bone marrow involvement, B symptoms (especially high fever) Anemia, pancytopenia, high LDH, occasional eosinophilia[] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[]

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