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40 Possible Causes for Degeneration of Epidermal Basal Cells, Eruptions

  • Erythema Multiforme

    We report a case of an erythema multiforme drug eruption associated with erythrodermic psoriasis induced by SOF and DCV.[] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[] Herein, we report a case who manifested severe erythema multiforme-like eruption with mucosal involvement associated with vemurafenib following nivolumab.[]

  • Discoid Lupus Erythematosus

    We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus.[] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[] Previously, a discoid lupus erythematosus-like eruption linked to its use was rarely reported in patients with rheumatoid arthritis.[]

  • Actinic Lichen Planus

    We established a diagnosis of ALP on the basis of the distribution of eruptions only on the sunlight-exposed areas and histological findings.[] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[] The eruption was distributed over sun-exposed areas, with particular predilection for the face.[]

  • Erythema Annulare Centrifugum

    EAC with cancers or paraneoplastic erythema annulare centrifugum eruptions (PEACE), is more likely to be associated with lymphoproliferative malignancies such as lymphomas[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[] A brief review of the mechanism and implications of this eruption are also included.[]

  • Tuberculid

    This report presents a case of a 6-month-old girl who developed generalized papulonecrotic tuberculid-like eruptions after BCG vaccination.[] The earlobe biopsy showed epidermal hyperkeratosis and parakeratosis, liquefaction degeneration of the basal cells, and follicular keratotic plugging, and the blood vessels[] The eruption cleared completely with antituberculous therapy.[]

  • Bullous Lichen Planus

    There were significant differences between familial and non-familial BLP in age of onset, duration of disease and extension of eruption (P[] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[] CONCLUSION: Familial bullous lichen planus is a chronic, progressive bullous eruption of the lower and upper extremities.[]

  • Photosensitivity Disorder

    Polymorphous light eruption This eruption is a reaction to sunlight (primarily UVA light) that is not fully understood.[] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[] Synonyms: photosensitive eruptions Photodermatoses are skin disorders that are precipitated by exposure to sunlight.[]

  • Chronic Lichenoid Pityriasis

    […] diseases characterized by the formation of fine, branny scales. acute lichenoid pityriasis an acute or subacute, sometimes relapsing, widespread macular, papular, or vesicular eruption[] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[] […] and regress over a period of weeks The acute form of pityriasis lichenoides, known as pityriasis lichenoides et varioliformis acuta (PLEVA), is characterized by the abrupt eruption[]

  • Rare Cutaneous Lichen Planus

    Lichenoid drug eruption (drug-induced lichen planus). Corona, R. (Ed.), UpToDate. topic last updated: Jan 09, 2018. Accessed September 10, 2018 June 25, 2018.[] There is a T-cell infiltrate at the dermo-epidermal junction, with vacuolar or liquefactive degeneration of the basal cells of the epidermis.[] […] typical holoprosencephaly [HPE] features showing absence of basal layer degeneration and melanin incontinence); other linear disorders like linear variety of fixed drug eruption[]

  • Erythema Marginatum

    Retrospective and prospective data on skin eruptions and prodromal symptoms were collected.[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[] The eruption is self-limited. Back to Dermatology Glossary - E Index Back to Dermatology Glossary Index[]

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