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2,712 Possible Causes for Degeneration of Epidermal Basal Cells, Mononeuritis Multiplex, Splenomegaly

  • Systemic Lupus Erythematosus

    A sensory or sensorimotor predominantly distal polyneuropathy is most common; however, the patchy deficits and subacute time course of mononeuritis multiplex and the rapidly[emedicine.medscape.com] […] relapsing illness, with a variety of different presentations. [ 5 , 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[patient.info] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Rheumatoid Arthritis

    Neurological: peripheral nerve entrapment, Atlanto-axial subluxation, polyneuropathy, mononeuritis multiplex.[patient.info] It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] multiplex) or progressive scleritis is typical of rheumatoid vasculitis.[hopkinsarthritis.org]

    Missing: Degeneration of Epidermal Basal Cells
  • Sarcoidosis

    Sarcoid neuropathy may present as sensorineural neuropathy, mononeuritis multiplex, or chronic inflammatory demyelinating neuropathy [ Vital et al. 2008 ].[doi.org] In this report, we describe the case of a 12-year-old girl presenting with fatigue and weight loss, with a painless hepato-splenomegaly without additional clinical signs on[ncbi.nlm.nih.gov] The indications of splenectomy include abdominal pain due to splenomegaly, hypersplenism, functional asplenia or spontaneous splenic rupture(6).[pneumologia.eu]

    Missing: Degeneration of Epidermal Basal Cells
  • Sjogren's Syndrome

    multiplex [ 13 ].[patient.info] On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[ncbi.nlm.nih.gov] […] development of NHL lymphoma include low complements (C3 and C4), presence of cryoglobulins, low CD4:CD8 ratio, persistence of unilateral or bilateral parotid gland enlargement, splenomegaly[ncbi.nlm.nih.gov]

    Missing: Degeneration of Epidermal Basal Cells
  • Amyloidosis

    PATIENT CONCERNS: We reported two cases with ApoA-1 amyloidosis, a 64-year-old man suffering from nephrotic syndrome and a 40-year-old man with nephrotic syndrome and splenomegaly[ncbi.nlm.nih.gov] Hepatomegaly is a frequent finding, 39 and although palpable splenomegaly is rare, evidence of splenic dysfunction is often apparent (table 5 ).[pmj.bmj.com] Hepatomegaly occurs in 25% of patients, whereas splenomegaly is present in less than 5% and macroglossia in only 10%.[circ.ahajournals.org]

    Missing: Degeneration of Epidermal Basal Cells
  • Hypereosinophilic Syndrome

    multiplex and muscle atrophy due to radiculopathy are sometimes encountered Generalized weakness is observed but is less specific Pulmonary findings are as follows: Rales[emedicine.medscape.com] Massive splenomegaly was a great point of challenge for diagnosis.[journals.plos.org] We present a 24-year-old-male with left lower quadrant abdominal pain, elevated eosinophil counts and splenomegaly.[ncbi.nlm.nih.gov]

    Missing: Degeneration of Epidermal Basal Cells
  • Vasculitis

    These include neurological (mononeuritis multiplex), abdominal (abdominal pain and gastrointestinal hemorrhage), respiratory (chest pain, pulmonary infiltrates and consolidation[symptoma.com] Gabriele Hahn, Pädiatrische Radiologie, Universitätsklinikum Carl Gustav Carus, TU Dresden); (B) Necrotizing skin vasculitis on legs and feet; (C) Splenomegaly, spleen with[frontiersin.org] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Lupus Erythematosus

    multiplex(in the absence of other known causes such as primary vasculitis), myelitis, peripheral or cranial neuropathy (in the absence of other known causes such as primary[rheumtutor.com] […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[els.net] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Felty's Syndrome

    multiplex (vasculitis) • hoarseness cricoarytenoid involvement • multiple basilar pulmonary nodules Caplan syndrome • dry eyes and/or mouth Sjögren syndrome • pleural effusion[mnemocine.wordpress.com] Computed tomography of the pelvis led to an incorrect diagnosis of malignancy, while radionuclide imaging using Tc-99m sulfur colloid confirmed the diagnosis of ectopic splenomegaly[ncbi.nlm.nih.gov] splenomegaly.[emedicine.medscape.com]

    Missing: Degeneration of Epidermal Basal Cells
  • Angioimmunoblastic Lymphadenopathy

    A 49-year-old man developed mononeuritis multiplex associated with angioimmunoblastic lymphadenopathy.[ncbi.nlm.nih.gov] A woman 68 years of age had fever, malaise, diffuse lymphadenopathy, splenomegaly followed by abdominal pain, and diarrhea.[ncbi.nlm.nih.gov] A 13-year-old girl presented with doughy swelling of both hands, a pruritic maculopapular rash, fever, malaise, lymphadenopathy and splenomegaly.[ncbi.nlm.nih.gov]

    Missing: Degeneration of Epidermal Basal Cells

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