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14 Possible Causes for Degeneration of Epidermal Basal Cells, Polyarteritis Nodosa, Syphilis

  • Vasculitis

    A biopsy of subcutaneous nodes finds an anatomopathologic lesion of polyarteritis nodosa.[] […] vasculitic workup assists in determining the organ systems involved and may include urinalysis, C-reactive protein, urea nitrogen/creatinine, CBC, ANCA and ANA testing, syphilis[] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[]

  • Systemic Lupus Erythematosus

    Nodosa Classification Polymyalgia Rheumatica Classification Rheumatoid Arthritis Classification 2010 ACR/EULAR RA Classification Criteria Excerpt Tree Format Complete Article[] […] with lupus tested positive for syphilis.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[]

  • Erythema Multiforme

    Secondary syphilis, the hematogenous spread of Treponema pallidum, usually occurs 4-10 weeks after initial exposure.[] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[] Tertiary syphilis may presents as neuro-syphilis, cardiovascular syphilis or late benign syphilis.[]

  • Lupus Erythematosus

    nodosa, • Scleroderma • Dermatomyositis 9.[] We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[]

  • Chronic Lichenoid Pityriasis

    Subcutaneous polyarteritis nodosa Pagetoid Bowen's disease vs. Extramammary Paget's disease Pale-cell acanthoma vs.[] A few, such as secondary syphilis and viral-associated lesions, also can be excluded based on serologic tests.[] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[]

  • Tuberculid

    Histology of nodular tuberculid may be identical or very similar to polyarteritis nodosa.[] In our case, the condition mimicked secondary syphilis because of the involvement of palms and soles.[] The earlobe biopsy showed epidermal hyperkeratosis and parakeratosis, liquefaction degeneration of the basal cells, and follicular keratotic plugging, and the blood vessels[]

  • Erythema Annulare Centrifugum

    nodosa 血栓性静脈炎 thrombophlebitis 5 海綿状態を呈する・血管周囲のみ炎症細胞浸潤がある炎症性疾患 多形慢性痒疹 prurigo chronica multiformis アトピー性皮膚炎 atopic dermatitis 6 乾癬様パターンをとる炎症性疾患 尋常性乾癬,遷延性病変(掻破による修飾) psoriasis[] Diagnosis: atypical secondary syphilis. Treatment: 0.8 million units of procaine penicillin i.m. per day 20 day.[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[]

  • Discoid Lupus Erythematosus

    nodosa, • Scleroderma • Dermatomyositis 9.[] Perioral dermatitis and rosacea Sarcoidosis Lichen planus Lichen planopilaris Dermatomyositis Syphilis (see secondary syphilis ) Porphyria (see erythropoietic protoporphyria[] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[]

  • Familial Primary Localized Cutaneous Amyloidosis

    nodosa 血栓症 thrombosis 限局性結節性過形成 focal nodular hyperplasia 原発性肝癌 primary liver cancer 原発性硬化性胆管炎 primary sclerosing cholangitis 原発性胆汁性肝硬変 primary biliary cirrhosis 症候性原発性胆汁性肝硬変[] […] described by Fontanus (Fonteyn) in 1639, but Rokitansky is credited with identifying a lardaceous or waxy amyloid-like degradation in tissue in association with tuberculosis, syphilis[] The major epidermal change observed was hyperkeratosis (90.90%), followed by acanthosis (72.71%), degeneration of basal cell layer (18.2%), elongated rete ridges (13.63%),[]

  • Zinc-Responsive Necrolytic Acral Erythema

    Finger clubbing, aphthous ulcers of the mouth, 338 cutaneous polyarteritis nodosa, 339. and 340. psoriasis, 341 pyostomatitis vegetans, 342. 343. and 344. erythema multiforme[] Striae 794 235 Subacute cutaneous lupus erythematosus 797 236 Subcorneal pustular dermatosis 802 237 Subcutaneous fat necrosis of the newborn 805 238 Sweet syndrome 807 239 Syphilis[] However, the focal nature of epidermal dyskeratosis and pallor, along with basal cell vacuolar degeneration can be useful in distinguishing NAE from other clinical mimickers[]

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