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13 Possible Causes for Degeneration of Epidermal Basal Cells, Splenomegaly

  • Lupus Erythematosus

    […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[els.net] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] Enlargement of the spleen (splenomegaly) occurs in about 10% of people.[msdmanuals.com]

  • Systemic Lupus Erythematosus

    […] relapsing illness, with a variety of different presentations. [ 5 , 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[patient.info] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] relapsing illness, with a variety of different presentations. [ 5, 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[patient.info]

  • ALK+ Histiocytosis

    Hypersplenism is a cytopenia resulting from blood pooling in the spleen and is almost always associated with splenomegaly.[radiopaedia.org] Involvement of the skin may be confined to small collections of cells at the dermal-epidermal interface with variable basal vacuolar degeneration or as dense infiltrates throughout[plasticsurgerykey.com] Fever, splenomegaly and hepatomegaly are the most common early findings; b. Lymph node enlargement, skin rash, and neurologic abnormali ties may also occur.[hopkinsmedicine.org]

  • Vasculitis

    Gabriele Hahn, Pädiatrische Radiologie, Universitätsklinikum Carl Gustav Carus, TU Dresden); (B) Necrotizing skin vasculitis on legs and feet; (C) Splenomegaly, spleen with[frontiersin.org] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] […] pericarditis, pericardial effusion, cardiac tamponade Ophthalmologic: conjunctivitis, episcleritis, uveitis, geographic serpiginous choroidopathy, visual loss Other: fever, splenomegaly[intechopen.com]

  • Zinc-Responsive Necrolytic Acral Erythema

    Other clinical features that may be present include mental retardation, splenomegaly, recurrent infections, a characteristic facies, and premature graying of the hair. 310[plasticsurgerykey.com] However, the focal nature of epidermal dyskeratosis and pallor, along with basal cell vacuolar degeneration can be useful in distinguishing NAE from other clinical mimickers[dermatologyadvisor.com]

  • Discoid Lupus Erythematosus

    Splenomegaly occurs in 10% of patients. Neurologic symptoms can result from involvement of any part of the central or peripheral nervous system or meninges.[merckmanuals.com] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov] Splenomegaly occurs in 10% of patients.[merckmanuals.com]

  • Tuberculid

    Additional clinical findings included fever (n 4), hepatomegaly (n 4), lymphadenopathy (n 3), phlyctenular conjunctivitis (n 3), and splenomegaly (n 2).[ncbi.nlm.nih.gov] The earlobe biopsy showed epidermal hyperkeratosis and parakeratosis, liquefaction degeneration of the basal cells, and follicular keratotic plugging, and the blood vessels[cmj.yiigle.com] Focal lymphocytic infiltrate and focal vacuolar degeneration of the basal cell layer were seen at the dermal-epidermal junction.[cyberleninka.org]

  • Chilblain Lupus Erythematosus

    Abdomen Check for hepatomegaly and splenomegaly.[patient.info] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com] Spleen (causing abdominal discomfort and distension due to splenomegaly).[patient.info]

  • Familial Primary Localized Cutaneous Amyloidosis

    Hepatomegaly occurs in 50% of patients and splenomegaly in 10%. Hepatomegaly was present in our case 1.[odermatol.com] The major epidermal change observed was hyperkeratosis (90.90%), followed by acanthosis (72.71%), degeneration of basal cell layer (18.2%), elongated rete ridges (13.63%),[pigmentinternational.com]

  • Photosensitivity Disorder

    Thirty-three months later, an increase in his white cell count (73 10 9 /L; 79% neutrophils) was associated with splenomegaly and splenic infarction that required emergency[bloodjournal.org] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[ncbi.nlm.nih.gov] There was also cervical lymphadenopathy, but no hepatomegaly or splenomegaly.[pmj.bmj.com]

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