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37 Possible Causes for Degeneration of Epidermal Basal Cells, Syphilis

  • Vasculitis

    […] vasculitic workup assists in determining the organ systems involved and may include urinalysis, C-reactive protein, urea nitrogen/creatinine, CBC, ANCA and ANA testing, syphilis[arupconsult.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] […] septicemic states, including meningococcal, gonococcal, Pseudomonas and Streptococcal septicemia, infective endocarditis (particularly due to Staphylococcus aureus), secondary syphilis[pathologyoutlines.com]

  • Erythema Multiforme

    Secondary syphilis, the hematogenous spread of Treponema pallidum, usually occurs 4-10 weeks after initial exposure.[ncbi.nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com] Tertiary syphilis may presents as neuro-syphilis, cardiovascular syphilis or late benign syphilis.[ejcrim.com]

  • Nonvenereal Endemic Syphilis

    Not to be confused with syphilis.[en.wikipedia.org] In the early lesion, there is loss of melanin in basal cells and liquefaction degeneration.[doi.org] Epidermal atrophy and the presence of many melanophages in the dermis are typical findings of late-stage pinta [60] .[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] counts of white or red blood cells, or platelets Immunologic disorder: abnormal immune tests include anti-DNA or anti-Sm (Smith) antibodies, falsely positive blood test for syphilis[medicinenet.com]

  • Erythema Annulare Centrifugum

    Diagnosis: atypical secondary syphilis. Treatment: 0.8 million units of procaine penicillin i.m. per day 20 day.[academic.oup.com] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in] Though histological changes made secondary syphilis a close possibility but duration of the illness for nearly 2 years with negative VDRL report excluded secondary syphilis[ijdvl.com]

  • Lichen Sclerosus

    Is the transmission via an insect vector (Lyme disease), sexually (venereal syphilis), or through casual person-to-person contact (endemic syphilis and pinta)?[cirp.org] […] with hydropic degeneration of basal cell, flattening of rete ridges, pronounced edema, and homogenization of collagen in upper dermis with lymphocytic infiltrate in mid-dermis[ncbi.nlm.nih.gov] Better modles for a spirochetal cause of LS might be those of endemic syphilis (bejel) or pinta.[cirp.org]

  • Discoid Lupus Erythematosus

    Perioral dermatitis and rosacea Sarcoidosis Lichen planus Lichen planopilaris Dermatomyositis Syphilis (see secondary syphilis ) Porphyria (see erythropoietic protoporphyria[visualdx.com] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov] George Kostant for performing the serologic tests for syphilis, to Dr. Frances Pasha and Dr.[nejm.org]

  • Chronic Lichenoid Pityriasis

    A few, such as secondary syphilis and viral-associated lesions, also can be excluded based on serologic tests.[dermaamin.com] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[e-ijd.org] With Psoriasis. ( 26522235 ) MartA-nez-Peinado C....Solorzano-Mariscal R. 2015 12 Demonstration of Treponema pallidum by immunohistochemistry in a patient with secondary syphilis[malacards.org]

  • Systemic Lupus Erythematosus

    […] with lupus tested positive for syphilis.[hopkinslupus.org] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] Syphilis Test : A false-positive syphilis test can reveal that a patient has anti-phospholipids present, and this false-positive test result is indicative that the patient[physio-pedia.com]

  • Actinic Lichen Planus

    […] reaction frequently are absent (Table 2). 2-4 Differential diagnosis of lichen planus actinicus includes discoid lupus erythematosus, granuloma annulare, melasma, secondary syphilis[mdedge.com] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com] Differential Diagnosis (Other conditions with similar appearance) Graft versus host disease Psoriasis, Guttate Lichen Nitidus Psoriasis, Plaque Lichen Simplex Chronicus Syphilis[ozarkderm.com]

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