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37 Possible Causes for Degeneration of Epidermal Basal Cells, Syphilis

  • Vasculitis

    […] vasculitic workup assists in determining the organ systems involved and may include urinalysis, C-reactive protein, urea nitrogen/creatinine, CBC, ANCA and ANA testing, syphilis[] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[] […] septicemic states, including meningococcal, gonococcal, Pseudomonas and Streptococcal septicemia, infective endocarditis (particularly due to Staphylococcus aureus), secondary syphilis[]

  • Erythema Multiforme

    Secondary syphilis, the hematogenous spread of Treponema pallidum, usually occurs 4-10 weeks after initial exposure.[] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[] Tertiary syphilis may presents as neuro-syphilis, cardiovascular syphilis or late benign syphilis.[]

  • Nonvenereal Endemic Syphilis

    Not to be confused with syphilis.[] In the early lesion, there is loss of melanin in basal cells and liquefaction degeneration.[] Epidermal atrophy and the presence of many melanophages in the dermis are typical findings of late-stage pinta [60] .[]

  • Lupus Erythematosus

    We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[] […] counts of white or red blood cells, or platelets Immunologic disorder: abnormal immune tests include anti-DNA or anti-Sm (Smith) antibodies, falsely positive blood test for syphilis[]

  • Erythema Annulare Centrifugum

    Diagnosis: atypical secondary syphilis. Treatment: 0.8 million units of procaine penicillin i.m. per day 20 day.[] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[] Though histological changes made secondary syphilis a close possibility but duration of the illness for nearly 2 years with negative VDRL report excluded secondary syphilis[]

  • Lichen Sclerosus

    Is the transmission via an insect vector (Lyme disease), sexually (venereal syphilis), or through casual person-to-person contact (endemic syphilis and pinta)?[] […] with hydropic degeneration of basal cell, flattening of rete ridges, pronounced edema, and homogenization of collagen in upper dermis with lymphocytic infiltrate in mid-dermis[] Better modles for a spirochetal cause of LS might be those of endemic syphilis (bejel) or pinta.[]

  • Discoid Lupus Erythematosus

    Perioral dermatitis and rosacea Sarcoidosis Lichen planus Lichen planopilaris Dermatomyositis Syphilis (see secondary syphilis ) Porphyria (see erythropoietic protoporphyria[] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[] George Kostant for performing the serologic tests for syphilis, to Dr. Frances Pasha and Dr.[]

  • Chronic Lichenoid Pityriasis

    A few, such as secondary syphilis and viral-associated lesions, also can be excluded based on serologic tests.[] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[] With Psoriasis. ( 26522235 ) MartA-nez-Peinado C....Solorzano-Mariscal R. 2015 12 Demonstration of Treponema pallidum by immunohistochemistry in a patient with secondary syphilis[]

  • Systemic Lupus Erythematosus

    […] with lupus tested positive for syphilis.[] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[] Syphilis Test : A false-positive syphilis test can reveal that a patient has anti-phospholipids present, and this false-positive test result is indicative that the patient[]

  • Actinic Lichen Planus

    […] reaction frequently are absent (Table 2). 2-4 Differential diagnosis of lichen planus actinicus includes discoid lupus erythematosus, granuloma annulare, melasma, secondary syphilis[] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[] Differential Diagnosis (Other conditions with similar appearance) Graft versus host disease Psoriasis, Guttate Lichen Nitidus Psoriasis, Plaque Lichen Simplex Chronicus Syphilis[]

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