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2,481 Possible Causes for degradation, envelope, meiotic, nuclear

Did you mean: degradation, envelope, miotic, nuclear

  • Osteoporosis

    […] if in studies using individual randomisation allocation concealment was described as by central allocation (telephone, web‐based, or sequentially numbered, opaque, sealed envelopes[] Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular[] Compared with GWLSs, GWASs can capitalize on all meiotic recombination events in a population, rather than only those in the families studied, and thus have higher statistical[] Author information 1 From the Department of Nuclear Medicine, Peking University People's Hospital, Beijing, China.[]

  • Malignant Neoplasm

    Although the silicone gel is encased in a silicone envelope when used in breast prostheses, there is good evidence that silicone gel sometimes “bleeds” through the envelope[] […] cancer cells to move, to become invasive, to resist programmed cell death (which otherwise threatens their existence once they leave the primary tumor), and even to release degradative[] . , 2002 , vol. 8 (pg. 346 - 353 ) 8 Meiotic arrest and aneuploidy in MLH3-deficient mice , Nat.[] Nuclear cytomegaly was present focally enhancing the atypical appearance of the tumor cell population in 17 cases. Mitoses were sparse ([]

  • Autosomal Recessive Ataxia Type Beauce

    A mutation in the synaptic nuclear envelope protein 1 (SYNE1) gene that is located on chromosome 6p25 results in premature termination of the protein.[] This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation.[] […] recombination (S. cerevisiae) 11 homolog A MRE11 homolog A, double strand break repair nuclease MRE11 meiotic recombination 11 homolog A (S. cerevisiae) MRE11 MRE11A 600814[] envelope spectrin repeat protein 1 , synaptic nuclear envelope 1 , spectrin repeat containing, nuclear envelope 1 , chromosome 6 open reading frame 98 , nesprin-1-like Did[]

  • Herpes Simplex Virus 1

    Herpes simplex virus 1 (HSV-1) envelope glycoprotein D (gD) plays an essential role in viral entry.[] (iii) The ICP0 C terminus is dispensable for PML I degradation.[] Nuclear egress of herpesviruses is accompanied by changes in the architecture of the nuclear membrane and nuclear lamina that are thought to facilitate capsid access to the[] IMPORTANCE HSV-1 glycoprotein B (gB) functions in the fusion of the viral envelope with cellular membranes during virus entry.[]

    Missing: meiotic
  • Emery-Dreifuss Muscular Dystrophy

    As we celebrate the 10th anniversary of the identification of emerin as a component of the nuclear envelope, I discuss here the available evidence that currently implicates[] […] the transmembrane domain responsible for nuclear membrane targeting, so its incorrect localization and lack of function could be due to abnormal folding resulting in rapid degradation[] To more precisely define the functions of LB3T in nuclear assembly, we have expressed subdomains of LB3T and determined their effects on nuclear assembly in Xenopus extracts[] KEYWORDS: Emery–Dreifuss muscular dystrophy; Muscle biopsy; Nuclear envelope; Nuclear envelope transmembrane protein[]

    Missing: meiotic
  • Polyploidy

    This can disrupt the balance of factors that normally mediate interactions between the chromosomes and nuclear components, including envelope-bound proteins.[] Importantly, we have discovered that E6 mutants defective in p53 degradation also induce polyploidy, although with lower efficiency.[] The fertility of early generation polyploids increases rapidly, owing largely to selection against meiotic configurations that generate unbalanced gametes.[] In this study, we show how Ras activation causes aberrant nuclear localization of phosphorylated mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK[]

  • Spinal and Bulbar Muscular Atrophy

    […] film Röntgenfilm {m} Maskulinum (der) X-ray film cassette Röntgenfilmkassette {f} Femininum (die) X-ray film disposal Röntgenfilmentsorgung {f} Femininum (die) X-ray film envelope[] This review illustrates the mechanisms at the basis of ARpolyQ degradation via the proteasomal and autophagic systems. Copyright 2010 Elsevier Inc. All rights reserved.[] Unlike most other trinucleotide repeat diseases, SBMA shows limited meiotic instability, and evidence thus far indicates absence of somatic instability in adults.[] In motoneurons, testosterone triggers nuclear toxicity by inducing AR nuclear translocation.[]

  • Triple A Syndrome

    Microscopic analysis of cells from a triple A patient revealed no morphological abnormalities of the nuclei, nuclear envelopes, or NPCs.[] In our cohort after the first decade of life, there does not appear to be any degradation of adrenal function over time.[] We then analyzed ALADIN’s localization throughout meiotic progression.[] Immunoblotting showed that fibroblasts from triple A patients (with known AAAS mutations) lack nuclear FTH1, suggesting that the nuclear translocation of FTH1 is defective[]

  • Autosomal Dominant Emery-Dreifuss Muscular Dystrophy

    Abstract Mutations in the LMNA gene encoding the nuclear envelope protein, lamins A and C, have been associated with at least nine distinct disorders now called laminopathies[] Homo sapiens Two-hybrid Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens View the network image/svg xml Pathways in which SYNE1 is involved Pathway Evidence Source Meiotic[] […] that several proteins of the nuclear scaffold are necessary in muscle cells to maintain the nuclear structural/functional integrity and a normal muscle cell metabolism.[] Together with mutations in EMD (refs 5,6), they underscore the potential importance of the nuclear envelope components in the pathogenesis of neuromuscular disorders.[]

    Missing: degradation
  • Progeria

    This phenotype is associated with ultrastructural perturbations to the nuclear envelope.[] We also evaluated the effect of associating rapamycin, which induces autophagic degradation of progerin and prelamin A.[] Our analysis indicated that MB treatment not only alleviated the mitochondrial defects but also rescued the hallmark nuclear abnormalities in HGPS cells.[] Treatment with rapamycin abolished nuclear blebbing, delayed the onset of cellular senescence, and enhanced the degradation of progerin in HGPS cells.[]

    Missing: meiotic