Possible Causes for delayed bone age Vitamin D Deficiency She presented with fractures during the first year-of-life followed by bone deformities, delayed development, failure-to-thrive, and pneumonias. [ncbi.nlm.nih.gov] […] tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes (softening of skull bones) - Delayed closure of anterior fontanelle - Frontal bossing [starship.org.nz] At 1 year-of-age, biochemical studies of serum revealed marked hyperphosphatasemia together with low-normal calcium and low inorganic phosphate and 25-hydroxyvitamin D levels [ncbi.nlm.nih.gov] Diabetes Mellitus Type 1 Bone age delay was more pronounced in boys, and in children with long-term median HbAlc levels of 7.5 - 9.0%. [ncbi.nlm.nih.gov] Bone age was retarded by -0.27 /- 1.1 years in the whole group, but particularly in the adolescents at the end of puberty ( 16 years; -0.76 /- 1.29y). [ncbi.nlm.nih.gov] Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes. [ncbi.nlm.nih.gov] Juvenile Idiopathic Arthritis If at all possible, joint reconstruction is delayed until childhood bone growth is complete (at about 18 years of age). [osmc.net] The main things to think about for surgery during childhood are the child's age and whether his or her bones are still growing. [osmc.net] Polyarticular Juvenile Idiopathic Arthritis If at all possible, joint reconstruction is delayed until childhood bone growth is complete (at about 18 years of age). [uofmhealth.org] The main things to think about for surgery during childhood are the child's age and whether his or her bones are still growing. [uofmhealth.org] Celiac Disease […] density Unexplained infertility Delayed puberty, late menarche/early menopause Unexplained miscarriage, premature birth, or small for gestational age infant Dental enamel [web.archive.org] […] migraine Dermatological manifestations (such as rash, psoriasis, blisters) Peripheral neuropathy Unexplained chronic hypertransaminasemia [57] Folic acid deficiency Reduced bone [worldgastroenterology.org] […] migraine Dermatological manifestations (such as rash, psoriasis, blisters) Peripheral neuropathy Unexplained chronic hypertransaminasemia [ 57 ] Folic acid deficiency Reduced bone [web.archive.org] Growth Failure Acquired GHD presents with significant growth failure with maintenance of weight percentiles and delayed bone age. [ncbi.nlm.nih.gov] ” bone age 14 Hyperpigmentation 13 Muscle weakness 13 Acanthosis nigricans 10 “Accelerated” bone age 10 Sleep disturbances 7 Pubertal Delay 7 Hypercalcemia 6 Alkalosis 6 Hypokalemia [csrf.net] Features of CDGP include later-than-average pubertal development, delayed bone age and, frequently, a family history of CDGP. [ncbi.nlm.nih.gov] Anorexia Nervosa bone mineral density with a bone age over 15, and in physiological dosage in those with delayed puberty and a bone age under 15. [patient.info] Oestrogen treatment is not advised routinely for females with anorexia by NICE, but may be considered for girls aged 13-17 years who have long-term low body weight and low [patient.info] Skeletal Dysplasia An adopted child, previous measurements suggested that he had grown at a normal rate since the end of the first year of life and his short stature with delayed bone age was [adc.bmj.com] A 14% of patients showed a low mean GH concentration during sleep, presenting also a markedly low IGF-1 level and marked delay of bone age [ 81 ]. [intechopen.com] hypotonia and bony abnormalities including marked cranial sclerosis and sclerosis of the ribs and long bones, which evolved in severity in the son between the ages of 2 [ncbi.nlm.nih.gov] Pituitary Dwarfism All had GHD biological confirmed and delayed bone age. [endocrine-abstracts.org] bone age. [accessanesthesiology.mhmedical.com] bone age, and low IGF levels. [en.wikipedia.org] Childhood Celiac Disease Additional findings included short stature, delayed bone age, and impaired xylose absorption. [hero.epa.gov] […] density Unexplained infertility Delayed puberty, late menarche/early menopause Unexplained miscarriage, premature birth, or small for gestational age infant Dental enamel [worldgastroenterology.org] […] migraine Dermatological manifestations (such as rash, psoriasis, blisters) Peripheral neuropathy Unexplained chronic hypertransaminasemia [ 57 ] Folic acid deficiency Reduced bone [worldgastroenterology.org] Addison Disease Please log in to edit this article. Edit Synonym: primary adrenal insufficiency German : Morbus Addison 1 Definition Addison's disease is a rare, but potentially lethal disease with a complete loss of function oft the adrenal glands. Addison's disease as a disease of the adrenal cortex ( primary adrenal insufficiency )[…] [flexikon.doccheck.com] Panhypopituitarism Furthermore, the hand-wrist X-ray showed delayed bone age [Figure 3], and bone densitometry revealed osteoporosis [total T-score 4.5 (spine) and 3.3 (hip)]. [ijem.in] Severely delayed bone age with open epiphyses facilitated this height gain. [ijem.in] Also, due to frequent delay in bone age in patients with hypopituitarism, a left hand and wrist radiography are helpful in determining bone age. [symptoma.com] Kallmann Syndrome CT scans may indicate delayed bone age. [symptoma.com] A delayed growth or puberty is obvious when the test reveals a bone age lesser than the chronological or actual age of the patients. [hxbenefit.com] This includes the following: Imaging X-rays of upper and lower limbs show decreased bone mass and density indicating a probable underlying hormone deficiency. [symptoma.com] Hypogonadotropic Hypogonadism In addition the boy developed delay of puberty, bone age, and closure of the epiphyseal lines of long bones with tall stature. [ncbi.nlm.nih.gov] He presented no signs of puberty, bone age of 14.5 years and insulin resistance. His sister, aged 16 years, also displayed delayed puberty. [ncbi.nlm.nih.gov] Furthermore, disturbances of skeletal development may be noted as an overall delayed bone age and a reduced peak bone mass. [symptoma.com] Ulcerative Colitis Abstract A 40-year-old man with a history of ulcerative colitis over 20 years was admitted to our hospital because of bloody diarrhea. Barium enema and endoscopic examination revealed two nodular tumors and many flat elevations surrounding tumors in the rectum. Total coloproctectomy was performed. H istological[…] [doi.org] Juvenile Myxedema When thyroid hormone is absent from birth, it leads to growth arrest, delayed bone age, and short stature. [thetrp.net] Children with poor linear growth, delayed bone age, and abnormal GH stimulation tests are considered GH deficient. [nursekey.com] In those presenting with marked growth failure, delayed bone age and other features of hypothyroidism, the thyroid gland is often not palpable due to the aggressive fibrous [indianpediatrics.net] Anterior Pituitary Hypofunction delayed fusion of epiphyses; bone growth does not match the age of the child - adults have hypoglycemia: decreased gluconeogenesis; loss of muscle mass; increased adipose [quizlet.com] in Hypopituitarism, neither ACTH or 11-deoxycortisol are increased 2) GROWTH H'MONE (GH): - decreased GH decreases synthesis & release of IGF-1 - children have growth delay [quizlet.com] Beta Thalassaemia Major This type can cause symptoms of moderate to severe anemia including: Extreme tiredness (fatigue) Pale skin Slow or delayed growth Weak bones Enlarged spleen Beta thalassemia [elcaminohospital.org] The diagnosis is most often made between ages 6 and 12. [elcaminohospital.org] Russell-Silver Syndrome However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal [ncbi.nlm.nih.gov] bone age Low birth weight Short height, short arms, stubby fingers and toes Stomach and intestine problems such as acid reflux and constipation The condition is usually diagnosed [nlm.nih.gov] X-ray abnormalities include: Delayed bone age. 'Ivory' epiphyses of distal phalanges. Small middle phalanx of the little finger - present in 4 out of 5 cases. [patient.info] Shwachman Syndrome Bone involvement is characterized by delayed bone age and maturation with metaphyseal dysplasia resulting in short stature, pectus carinatum, and generalized osteopenia. [orpha.net] Skeletal manifestations include delayed bone age with marked carpal delay, broad cup-like anterior ribs, metaphyseal irregularities, and coxa vara with short femoral necks [mirc.rsna.org] Shwachman-Diamond syndrome is a presumed autosomal recessive condition associated with exocrine pancreatic insufficiency with fat replacement of the pancreas, short stature, bone [mirc.rsna.org] Sickle Cell Anemia A 54-year-old Afro-Caribbean woman had a delayed diagnosis of homozygous sickle cell disease at 7 years of age by hemoglobin electrophoresis. [ncbi.nlm.nih.gov] Children with sickle cell anemia may have delayed growth and reach puberty at a later age than normal. [medical-dictionary.thefreedictionary.com] The complications of sickle cell disease she experienced included bone pain, a chronic right leg ulcer, avascular necrosis of her left hip, and symptomatic cholelithiasis. [ncbi.nlm.nih.gov] Minimal Change Nephropathy From Wikidata Jump to navigation Jump to search Human disease Minimal Change Glomerulonephritis Minimal change disease (disorder) Nephrotic syndrome with Lesion of Minimal Change Glomerulonephritis Nephrotic syndrome with lesion of minimal change glomerulonephritis Nephrotic syndrome with lesion of minimal change[…] [wikidata.org] Nephrotic Syndrome Spontaneous bacterial peritonitis is a serious and frequent complication in childhood nephrotic syndrome. However, this type of complication is very rare in adult nephrotic patients. In the review realized only 15 cases are published with this complication, and none of them after the year 2000. Later we expose the[…] [ncbi.nlm.nih.gov] Turner Syndrome Radiographic examination revealed delayed bone age and pelvic ultrasonography demonstrated an immature uterus. [ncbi.nlm.nih.gov] Bone age: usually normal before adolescence but is then delayed because of oestrogen deficiency. [patient.info] Bone age should be performed before starting growth hormone or oestrogen therapy. Growth hormone is contra-indicated if the epiphyses are fused. [patient.info] Mucopolysaccharidosis Mucopolysaccharidosis type IVB (MPS IVB) is a very rare lysosomal storage disorder characterized by skeletal dysplasia, hearing disorder, and cardiac valvular disease. Herein, we report an extremely rare manifestation of MPS IVB in a 60-year-old female patient who underwent a successful aortic valve replacement. The[…] [ncbi.nlm.nih.gov] Niemann-Pick Disease Type B bone age Intellectual disabilities Short stature PROGNOSIS Individuals with Niemann-Pick Disease Type A have onset of symptoms such as failing to gain weight and grow appropriately [evolvegene.com] They also have short stature and slowed mineralization of bone (delayed bone age). [ghr.nlm.nih.gov] […] abnormality (cherry red spot) Anemia Type B Enlarged liver/spleen Lung infections Eye abnormality (cherry red spot) Low blood platelets number (thrombocytopenia) Short stature Delayed [evolvegene.com] Iatrogenic Cushing's Disease The indica ted treatment was topical with hydrocortisone acetate and delayed bone age (BA) (6 months BA for 1 year 3 months in chronological age). [scielo.conicyt.cl] Furthermore, bone age is typically delayed by a mean of 2 yr (range -0.5 to 4.1 yr) (18). [scielo.br] Coffin-Lowry Syndrome Involvement of the musculoskeletal system presents as short thorax, bifid sternum, pectus excavatum or carinatum, vertebral dysplasia, kyphosis, scoliosis, delayed bone age [accessanesthesiology.mhmedical.com] Patients are usually short with delayed bone age; joints are hyperextensible. The cognitive function of affected males is usually severely impaired. [genedx.com] Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis Andersen-Tawil Syndrome NORD gratefully acknowledges Rabi Tawil, MD, Professor of Neurology, University of Rochester Medical Center, for assistance in the preparation of this report. Synonyms of Andersen-Tawil Syndrome Andersen syndrome ATS long QT syndrome 7 LQTS7 General Discussion Summary Andersen-Tawil[…] [rarediseases.org] Aarskog-Scott Syndrome The main findings are asynchronic and delayed bone age, shortened long tubular bones with wide metaphyses, brachyphalangy, hypoplasia of the middle phalanges of the fifth [ncbi.nlm.nih.gov] Other Manifestations delayed puberty mild pectus excavatum prominent umbilicus INVESTIGATIONS: 1. Imaging Studies 1. Skeletal X-Rays delayed bone age MANAGEMENT: 1. [web.archive.org] The major manifestations of this syndrome include short stature decreased bone age craniofacial anomalies hypertelorism broad forehead broad nasal bridge short nose with anteverted [radiopaedia.org]
