Delayed Bone Age: Causes & Reasons

Possible Causes for Delayed Bone Age

However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal [ncbi.nlm.nih.gov]

bone age Low birth weight Short height, short arms, stubby fingers and toes Stomach and intestine problems such as acid reflux and constipation The condition is usually diagnosed [nlm.nih.gov]

X-ray abnormalities include: Delayed bone age. 'Ivory' epiphyses of distal phalanges. Small middle phalanx of the little finger - present in 4 out of 5 cases. [patient.info]

Delayed Male Puberty

Bone age: a delayed bone age may occur in CDGP, growth hormone deficiency and hypothyroidism. Bone age is established by a wrist X-ray. [patient.info]

[…] of exclusion) Consistent findings Delayed Bone Age Family History of Delayed Puberty (75% have parental Pubertal Delay) Consider Jump Start Therapy Indications Girls over [fpnotebook.com]

An X-ray of the hand would assess bone age. One of the criterion for CDPG is a bone age delay of greater than 2 years, but this is not specific to CDPG. [lecturio.com]

Spondyloepimetaphyseal Dysplasia Type SPONASTRIME

bone age. [ncbi.nlm.nih.gov]

bone age Delayed carpal bone ossification Flattened capital femoral epiphyses Hypoplastic epiphyses Irregular metaphyses Kyphoscoliosis Limited elbow extension Lumbar lordosis [datagenno.com]

[…] include a concavity in the posterior two thirds of lumbar vertebral bodies, platyspondyly, thoracolumbar scoliosis, marginal irregularity and striations of metaphyses, and delayed [ncbi.nlm.nih.gov]

Juvenile Myxedema

When thyroid hormone is absent from birth, it leads to growth arrest, delayed bone age, and short stature. [thetrp.net]

Children with poor linear growth, delayed bone age, and abnormal GH stimulation tests are considered GH deficient. [nursekey.com]

In those presenting with marked growth failure, delayed bone age and other features of hypothyroidism, the thyroid gland is often not palpable due to the aggressive fibrous [indianpediatrics.net]

IMAGE Syndrome

Additional manifestations include postnatal growth failure and delayed bone age, mild developmental delay, macrocephaly, mild facial dysmorphism (with frontal bossing, wide [orpha.net]

bone age. [ncbi.nlm.nih.gov]

Imaging findings Metaphyseal and/or epiphyseal dysplasia, mesomelia, osteopenia, gracile long bones, and delayed bone age on radiographs Note: Skeletal abnormalities, which [ncbi.nlm.nih.gov]

SHORT Syndrome

bone age, delayed speech, normal intellect, glucose intolerance, and insulinopenic diabetes. [ncbi.nlm.nih.gov]

Additionally, the patients usually present a low birth weight and height, lipodystrophy, delayed bone age, hernias, low body mass index and a progeroid appearance. [ncbi.nlm.nih.gov]

bone age delayed speech glucose intolerance insulinopenic diabetes Affected individuals are thought to have normal intellect or mild intellectual disability. [radiopaedia.org]

Shwachman Syndrome

Skeletal manifestations include delayed bone age with marked carpal delay, broad cup-like anterior ribs, metaphyseal irregularities, and coxa vara with short femoral necks [mirc.rsna.org]

Bone involvement is characterized by delayed bone age and maturation with metaphyseal dysplasia resulting in short stature, pectus carinatum, and generalized osteopenia. [orpha.net]

Shwachman-Diamond syndrome is a presumed autosomal recessive condition associated with exocrine pancreatic insufficiency with fat replacement of the pancreas, short stature, bone [mirc.rsna.org]

Dubowitz Syndrome

Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis [ncbi.nlm.nih.gov]

Skeletal issues can be delayed bone age, fifth finger clinodactyly, two/three toe syndactyly, and pes planus. Some are very prone to eczema or have severe allergies. [dubowitzsyndrome.net]

Spondylocarpotarsal Synostosis

In addition to the typical findings of this disorder, he demonstrated ossification delay of multiple epiphyses (especially delayed carpal bone age) and bilateral proximal [bio2rdf.org]

bone age. [docslide.fr]

In addition to the typical phenotype of SCT syndrome, he showed pronounced delay of carpal bone age and bilateral epiphyseal dysplasia of the proximal femora. [ncbi.nlm.nih.gov]

Niemann-Pick Disease Type B

bone age Intellectual disabilities Short stature PROGNOSIS Individuals with Niemann-Pick Disease Type A have onset of symptoms such as failing to gain weight and grow appropriately [evolvegene.com]

They also have short stature and slowed mineralization of bone (delayed bone age). [ghr.nlm.nih.gov]

[…] abnormality (cherry red spot) Anemia Type B Enlarged liver/spleen Lung infections Eye abnormality (cherry red spot) Low blood platelets number (thrombocytopenia) Short stature Delayed [evolvegene.com]

Kenny-Caffey Syndrome Type 1

Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature. [accessanesthesiology.mhmedical.com]

(see photos below) Delayed bone age Short or very short stature Low blood calcium High blood phosphorus Carious teeth Other dental abnormalities Normal intelligence in most [forgottendiseases.org]

Radiographic evaluation revealed short metacarpal bones and delayed bone age. [typeset.io]

Rubinstein-Taybi Syndrome

Additional observations include maternal pre-eclampsia (2/9), syndactyly (3/9), feeding or swallowing issues (3/9), delayed bone age (2/9) and scoliosis (2/9). [ncbi.nlm.nih.gov]

Other features include cryptorchidism, microcephaly, speech delay, delayed bone age, gastroesophageal reflux, coloboma, renal abnormalities and congenital heart defects. [preventiongenetics.com]

bone age) Broad nasal bridge Malformed ears High arched palate Extra fold of skin on either side of the nose Small head (microcephaly) Small lower jaw Flat red birthmark [aapos.org]

Multiple Congenital Anomalies - Hypotonia - Seizures Type 3

[…] ossification centers, wide and long femoral necks, and delayed bone age. [bio2rdf.org]

delayed bone age, pectus excavatum and osteopenia), inverted nipples and dysmorphic features including high and narrow forehead, frontal bossing, short nose, depressed nasal [mendelian.co]

All patients also had some type of skeletal findings, including scoliosis, pectus excavatum, short upper extremities, slender and osteopenic long bones with large secondary [bio2rdf.org]

Pituitary Dwarfism

All had GHD biological confirmed and delayed bone age. [endocrine-abstracts.org]

bone age. [accessanesthesiology.mhmedical.com]

bone age, and low IGF levels. [en.wikipedia.org]

Acrootoocular Syndrome

bone age; and intellectual disability. [diseaseinfosearch.org]

bone age Skeletal Feet: small feet widely spaced 1st-2nd toes zygodactyly short 3rd-4th toes protruding calcaneus Growth Weight: birthweight Abdomen Gastrointestinal: multiple [malacards.org]

[…] features that have been reported include generalized obesity starting from early childhood; macrocephaly; ocular abnormalities (especially retinal or choroid coloboma); delayed [diseaseinfosearch.org]

Sporadic Goitrous Cretinism

delayed bone age, considered to be the result of malnutrition. [archive.unu.edu]

Delayed bone age; "stippling" of epiphyses. General Considerations The causes of cretinism and juvenile hypothyroidism are as follows (after Wilkins): A. [generalhealthtopics.com]

X-ray examination showed marked retardation in bone maturation. The bone age of the carpus and metacarpus was delayed. [archive.unu.edu]

Coffin-Lowry Syndrome

Involvement of the musculoskeletal system presents as short thorax, bifid sternum, pectus excavatum or carinatum, vertebral dysplasia, kyphosis, scoliosis, delayed bone age [accessanesthesiology.mhmedical.com]

Patients are usually short with delayed bone age; joints are hyperextensible. The cognitive function of affected males is usually severely impaired. [genedx.com]

Aarskog-Scott Syndrome

The main findings are asynchronic and delayed bone age, shortened long tubular bones with wide metaphyses, brachyphalangy, hypoplasia of the middle phalanges of the fifth [ncbi.nlm.nih.gov]

Other Manifestations delayed puberty mild pectus excavatum prominent umbilicus INVESTIGATIONS: 1. Imaging Studies 1. Skeletal X-Rays delayed bone age MANAGEMENT: 1. [web.archive.org]

Puberty is usually delayed with a delayed bone age and pubertal height gain is suppressed.[17] Final height is reported to be between 150 cm and 160 cm in male patients, and [cjhr.org]

Sanjad-Sakati Syndrome

[…] recessive inheritance - Beaked nose - Deepset eyes / enophthalmos - Delayed bone age - Depressed nasal bridge - External ear anomalies - Failure to thrive / difficulties [csbg.cnb.csic.es]

bone age Delayed bone age Osteosclerosis Patchy osteosclerosis Poorly ossified skull bones Thickened cortex and narrow marrow cavities of long bones Small hands and feet [ncbi.nlm.nih.gov]

Other medical problems that occur in SSS are as follows: Common problems in Sanjad-Sakati syndrome Microcephaly (small head) Delayed bone age Small hands and/or feet Short [forgottendiseases.org]

Wolf-Hirschhorn Syndrome

At autopsy, the fetus showed typical craniofacial dysmorphic signs of WHS, severe IUGR and delayed bone age. [ncbi.nlm.nih.gov]

Occasional abnormalities include heart defects, hypospadias, scoliosis, ptosis, fused teeth, hearing loss, delayed bone age, low hairline with webbed neck, and renal anomalies [bionity.com]

Radiological evidence of delayed bone age. [accessanesthesiology.mhmedical.com]

Schwartz-Jampel Syndrome

bone age, epiphyseal anomaly, kyphosis, scoliosis, pectus carinatum, abnormal vertebral size/shape, anterior bowing of the long bones). [accesspediatrics.mhmedical.com]

bone age. [4] Other less common reported features include high pitched voice, [5] bilateral carpal tunnel syndromes, [6] and malignant hyperthermia. [7] Creatine kinase and [advbiores.net]

“fixed” facies, low-set ears, short neck), and musculoskeletal signs (myopathy, myotonia, muscular hypertrophy, restricted joint mobility, osteoporosis, dislocated hip, delayed [accesspediatrics.mhmedical.com]

MOMO Syndrome

Previous publications have observed multiple associations with this syndrome, such as intellectual disability, delayed bone age, and skeletal abnormalities. [pennstate.pure.elsevier.com]

bone age; and intellectual disability. [globalgenes.org]

Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations

age in Larsen syndrome; normal or delayed bone age in CHST3 skeletal dysplasia Diastrophic dysplasia SLC26A2 AR Short limbs Clubfeet Joint stiffness / limited mobility Hitchhiker [ncbi.nlm.nih.gov]

Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body. [ncbi.nlm.nih.gov]

[…] syndrome; ↓ in CHST3 skeletal dysplasia Distinctive facial features in Larsen syndrome, w/↑ incidence of cleft palate; normal facies in CHST3 skeletal dysplasia Advanced bone [ncbi.nlm.nih.gov]

CODAS Syndrome

Diagnostic methods X-rays show delayed ossification, delayed bone age and spine and pelvic anomalies. [orpha.net]

[…] anomalies were quite similar, with delayed bone age, epiphyseal dysplasia, and vertebral clefts. [jmg.bmj.com]

(H) Left hand at 3 years 9 months of age showing delayed bone age, dysharmonic ossification, abnormal epiphyses of the phalanges, and pseudoepiphyses of the metacarpals. [jmg.bmj.com]

Meier-Gorlin Syndrome

Clinical aspects Short stature, very slender, poor weight gain, delayed bone age, and absent patellae may be signs, but they are more part of the delayed bone age. [accessanesthesiology.mhmedical.com]

Many also suffer from scoliosis, hip dislocation, delayed bone age, radial head dislocation, and seizures. [isabellasbigdreams.co.uk]

Some patients may have other skeletal abnormalities, such as unusually narrow long bones in the arms and legs, genu recurvatum, and delayed bone age. [cags.org.ae]

3M Syndrome Type 2

Additional skeletal abnormalities, such as unusually slender long bones in the arms and legs; tall, narrow spinal bones (vertebrae); or slightly delayed bone age may be apparent [medlineplus.gov]

Signs & Symptoms Three M syndrome is an extremely rare inherited disorder characterized by low birth weight, delayed bone age, and short stature; characteristic malformations [rarediseases.org]

Full size image Skeletal changes were not consistently present at birth but occurred in the course of the disease, namely delayed bone age, slender long bones and tall vertebral [nature.com]

Geleophysic Dysplasia Type 2

Radiological manifestations include delayed bone age, cone-shaped epiphyses, shortened long tubular bones and ovoid vertebral bodies. [orpha.net]

Radiologic features include delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and ovoid vertebral bodies. [diseaseinfosearch.org]

Coffin-Siris Syndrome

bone age, and hypoplastic or absent fifth fingers/toes or nails, together with developmental delay. [neurologyindia.com]

Feeding difficulties and frequent respiratory infections during infancy, diminished muscle tone (hypotonia), abnormal looseness (laxity) of the joints, delayed bone age, developmental [rarediseases.org]

In many cases spinal abnormalities have been recognized: spina bifida, scoliosis, kyphosis and delayed bone age. [ispub.com]

Camptodactyly Syndrome Type Guadalajara III

Radiographic studies revealed spina bifida occulta at cervical and dorso-lumbar levels, increased bone trabeculae, cortical thickening and delayed bone age. [insights.ovid.com]

bones, and delayed bone age. [accessanesthesiology.mhmedical.com]

Fragility 516 Multiple Radiolucent Defects Lytic Lesions 527 Osteolyses 538 Delayed Bone Age 548 Asymmetry Hemihypertrophy Hemiatrophy 562 Aarskog Syndrome 576 Achondroplasia [books.google.es]

Ruijs Aalfs Syndrome

The boy was noted to have growth retardation at age 3 years; at age 7 he was found to have thoracic kyphosis, frontal bossing, and a delayed bone age of approximately 3 years [mendelian.co]

Ruijs et al. (2003) reported a Moroccan boy with a chromosomal breakage who died of hepatocellular carcinoma at age 17 years. [ncbi.nlm.nih.gov]

Description Ruijs et al. (2003) reported a Moroccan boy with a chromosomal breakage who died of hepatocellular carcinoma at age 17 years. [mendelian.co]