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1,026 Possible Causes for Delayed Bone Age, Flat Supraorbital Ridges, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    Facial appearance is characteristic with narrow or triangular shaped head and high or sloping forehead, flat supraorbital ridge, scanty lateral eyebrows, short palpebral fissures[orpha.net] Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] bone age Low birth weight Short height, short arms, stubby fingers and toes Stomach and intestine problems such as acid reflux and constipation The condition is usually diagnosed[nlm.nih.gov]

    Missing: Flat Supraorbital Ridges
  • Seckel Syndrome

    bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] age delay 2 6 9.[scielo.br]

    Missing: Flat Supraorbital Ridges
  • Coffin-Lowry Syndrome

    supraorbital ridges with bushy brows, downwardly slanted palpebral fissures, hypertelorism, blepharoptosis, large and prominent ears, large nose with broad base and elongated[accessanesthesiology.mhmedical.com] Patients are usually short with delayed bone age; joints are hyperextensible. The cognitive function of affected males is usually severely impaired.[genedx.com] Involvement of the head and neck can present as thickened calvarium, small sinuses paranasales, flat occiput, delayed suture closure with large anterior fontanelle, prominent[accessanesthesiology.mhmedical.com]

    Missing: Wide Space Between the First and Second Toe
  • Kenny-Caffey Syndrome Type 1

    Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature.[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com] (see photos below) Delayed bone age Short or very short stature Low blood calcium High blood phosphorus Carious teeth Other dental abnormalities Normal intelligence in most[forgottendiseases.org]

    Missing: Flat Supraorbital Ridges
  • SHORT Syndrome

    Other features can be hypoplasia of the malar bones, broad flat nasal root, prominent supraorbital ridges, relative prognathism, and mild telecanthus with or without hypertelorism[whonamedit.com] bone age, delayed speech, normal intellect, glucose intolerance, and insulinopenic diabetes.[ncbi.nlm.nih.gov] Additionally, the patients usually present a low birth weight and height, lipodystrophy, delayed bone age, hernias, low body mass index and a progeroid appearance.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Vitamin D Deficiency

    She presented with fractures during the first year-of-life followed by bone deformities, delayed development, failure-to-thrive, and pneumonias.[ncbi.nlm.nih.gov] […] tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes (softening of skull bones) - Delayed closure of anterior fontanelle - Frontal bossing[starship.org.nz] At 1 year-of-age, biochemical studies of serum revealed marked hyperphosphatasemia together with low-normal calcium and low inorganic phosphate and 25-hydroxyvitamin D levels[ncbi.nlm.nih.gov]

    Missing: Flat Supraorbital Ridges Wide Space Between the First and Second Toe
  • Zellweger Syndrome

    The clinical findings of the ZS are dysmorphic features (prominent forehead, hypertelorism, epicanthal folds, flat supraorbital ridges, broad nasal bridge, large fontanelles[neuropathology-web.org]

    Missing: Wide Space Between the First and Second Toe
  • Gorlin-Chaudhry-Moss Syndrome

    Bone age above the 90th percentile. Early verbal and motor delays.[vivavoceoralmedicineradiology.com] , developmental delay, short fingers and toes, fifth finger clinodactyly, single transverse palmar crease, sandal gap, delayed bone age, abnormal spine, sternum curvature,[vivavoceoralmedicineradiology.com] Teeth manifestation: Anodontia, delayed dentition, malformed teeth.[vivavoceoralmedicineradiology.com]

    Missing: Wide Space Between the First and Second Toe
  • Weaver Syndrome

    Physical findings included prominent supraorbital ridges, downslanting palpebral fissures, a broad nose with full nasal tip, pointed chin, tall slender build, and flat feet[karger.com] delay.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

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