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1,014 Possible Causes for Delayed Bone Age, Flattening of the Talar Dome, Mutation in the PHEX Gene

  • X-Linked Hypophosphatemia

    To date, 131 mutations in the PHEX gene have been reported.[ncbi.nlm.nih.gov] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov] The main symptoms are severe bone deformities, particularly a characteristic bowing of the legs.[omicsonline.org]

  • Vitamin D Deficiency

    […] in the PHEX gene.[ncbi.nlm.nih.gov] She presented with fractures during the first year-of-life followed by bone deformities, delayed development, failure-to-thrive, and pneumonias.[ncbi.nlm.nih.gov] […] tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes (softening of skull bones) - Delayed closure of anterior fontanelle - Frontal bossing[starship.org.nz]

    Missing: Flattening of the Talar Dome
  • Diabetes Mellitus Type 1

    Bone age delay was more pronounced in boys, and in children with long-term median HbAlc levels of 7.5 - 9.0%.[ncbi.nlm.nih.gov] Bone age was retarded by -0.27 /- 1.1 years in the whole group, but particularly in the adolescents at the end of puberty ( 16 years; -0.76 /- 1.29y).[ncbi.nlm.nih.gov] Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes.[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Juvenile Rheumatoid Arthritis

    If at all possible, joint reconstruction is delayed until childhood bone growth is complete (at about 18 years of age).[mottchildren.org] The main things to think about for surgery during childhood are the child's age and whether his or her bones are still growing.[mottchildren.org]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Polyarticular Juvenile Idiopathic Arthritis

    If at all possible, joint reconstruction is delayed until childhood bone growth is complete (at about 18 years of age).[uofmhealth.org] The main things to think about for surgery during childhood are the child's age and whether his or her bones are still growing.[uofmhealth.org]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Growth Failure

    Acquired GHD presents with significant growth failure with maintenance of weight percentiles and delayed bone age.[ncbi.nlm.nih.gov] bone age 14 Hyperpigmentation 13 Muscle weakness 13 Acanthosis nigricans 10 “Accelerated” bone age 10 Sleep disturbances 7 Pubertal Delay 7 Hypercalcemia 6 Alkalosis 6 Hypokalemia[csrf.net] Features of CDGP include later-than-average pubertal development, delayed bone age and, frequently, a family history of CDGP.[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Celiac Disease

    […] density Unexplained infertility Delayed puberty, late menarche/early menopause Unexplained miscarriage, premature birth, or small for gestational age infant Dental enamel[web.archive.org] […] migraine Dermatological manifestations (such as rash, psoriasis, blisters) Peripheral neuropathy Unexplained chronic hypertransaminasemia [ 57 ] Folic acid deficiency Reduced bone[web.archive.org]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Anorexia Nervosa

    bone mineral density with a bone age over 15, and in physiological dosage in those with delayed puberty and a bone age under 15.[patient.info] Oestrogen treatment is not advised routinely for females with anorexia by NICE, but may be considered for girls aged 13-17 years who have long-term low body weight and low[patient.info]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Skeletal Dysplasia

    A 14% of patients showed a low mean GH concentration during sleep, presenting also a markedly low IGF-1 level and marked delay of bone age [ 81 ].[intechopen.com] , hypotonia and bony abnormalities including marked cranial sclerosis and sclerosis of the ribs and long bones, which evolved in severity in the son between the ages of 2[ncbi.nlm.nih.gov] Marques et al. [ 74 ] reported a 10-year-old girl with two heterozygous nonsense TRPS1 mutations with significantly reduced growth velocity and delayed bone age.[intechopen.com]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Pituitary Dwarfism

    All had GHD biological confirmed and delayed bone age.[endocrine-abstracts.org] bone age.[accessanesthesiology.mhmedical.com] bone age, and low IGF levels.[en.wikipedia.org]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene

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