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2,616 Possible Causes for Delayed Bone Age, Raynaud's Disease, Wide Space Between the First and Second Toe

  • Diabetes Mellitus Type 1

    Bone age delay was more pronounced in boys, and in children with long-term median HbAlc levels of 7.5 - 9.0%.[ncbi.nlm.nih.gov] Bone age was retarded by -0.27 /- 1.1 years in the whole group, but particularly in the adolescents at the end of puberty ( 16 years; -0.76 /- 1.29y).[ncbi.nlm.nih.gov] Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Mucopolysaccharidosis

    Mucopolysaccharidosis type IVB (MPS IVB) is a very rare lysosomal storage disorder characterized by skeletal dysplasia, hearing disorder, and cardiac valvular disease. Herein, we report an extremely rare manifestation of MPS IVB in a 60-year-old female patient who underwent a successful aortic valve replacement. The[…][ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Myxedema

    Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate with pathologic enlargement. This report describes an atypical case of morbidity with massive macroglossia secondary to myxedema; the[…][ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Sickle Cell Disease

    A 54-year-old Afro-Caribbean woman had a delayed diagnosis of homozygous sickle cell disease at 7 years of age by hemoglobin electrophoresis.[ncbi.nlm.nih.gov] Children with sickle cell anemia may have delayed growth and reach puberty at a later age than normal.[medical-dictionary.thefreedictionary.com] The complications of sickle cell disease she experienced included bone pain, a chronic right leg ulcer, avascular necrosis of her left hip, and symptomatic cholelithiasis.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Cutis Laxa

    At 18 months, he is normotensive with resolution of his secondary vascular headaches and new symptoms of Raynaud phenomenon.[pediatrics.aappublications.org] Radiological investigation of the hand wrist bone showed a markedly delayed bone age.[karger.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Seckel Syndrome

    G.Maurice Raynaud (1834-1881) French physician Rebuck レバック Rebuck skin window レバック皮膚開窓 Recklinghausen レックリングハウゼン von Recklinghausen's disease フォンレックリングハウゼン病 FriedrichDaniel[jams.med.or.jp] bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    Hepatosplenomegaly, Raynaud's phenomenon, hyperhidrosis of the feet and hands, and delayed dentition and puberty have been reported ocassionally. 15 Anemia, leukopenia, increased[elsevier.es] Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature.[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com]

  • Dubowitz Syndrome

    Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Skeletal issues can be delayed bone age, fifth finger clinodactyly , two/three toe syndactyly , and pes planus . Some are very prone to eczema or have severe allergies.[dubowitzsyndrome.net]

    Missing: Raynaud's Disease
  • Juvenile Rheumatoid Arthritis

    Symptoms and Signs Raynaud syndrome (Raynaud phenomenon) may precede other manifestations by years.[merck.com] If at all possible, joint reconstruction is delayed until childhood bone growth is complete (at about 18 years of age).[osmc.net] Calcium channel blockers (eg, nifedipine ) and phosphodiesterase inhibitors (eg, tadalafil ) for Raynaud phenomenon General management and initial drug therapy are tailored[merck.com]

    Missing: Wide Space Between the First and Second Toe
  • Juvenile Myxedema

    ’s disease and Raynaud’s phenomenon caused by exposure to cold, ergotamin, etc.[ktthebest4u.blogspot.com] When thyroid hormone is absent from birth, it leads to growth arrest, delayed bone age, and short stature.[thetrp.net] Oesophagus Swallowing becomes difficult Skeletal muscle Inflamed weak muscles Lungs Reduced oxygen intake Joints Arthritis Blood vessels Raynaud phenomenon Kidneys Renal failure[dermnetnz.org]

    Missing: Wide Space Between the First and Second Toe

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